CAS: 2019-34-3; 3-(4-Chlorophenyl)Propanoic Acid

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CAS号1615-02-7 4-氯肉桂酸 | CAS号67-56-1 甲醇 | CAS号2033-24-1 丙二酸环(亚)异丙酯 | CAS号104-88-1 对氯苯甲醛 | CAS号1073-67-2 对氯苯乙烯 | CAS号64-18-6 甲酸 | CAS号144-62-7 草酸 | CAS号201230-82-2 carbon monoxide | CAS号1772-43-6 2,4,4-三甲基-2-恶唑 | CAS号104-83-6 4-氯氯苄 | CAS号3506-75-0 4-(4-氯苯基)-2-丁酮 | CAS号6282-88-8 3-(4-氯苯基)丙-1-醇 | CAS号75677-02-0 3-(4-氯-苯基)-丙醛 | CAS号57292-44-1 B°C-D-4-氯苯丙氨酸 | CAS号14548-38-0 6-氯-1-茚满酮 | CAS号156-41-2 对氯苯乙胺 | CAS号18655-50-0 3-(4-氯代苯基)丙胺 | CAS号7116-36-1 4-氯苯丙酸乙酯 | CAS号77605-68-6 7-chloro-1-phen... | CAS号90944-90-4 3-(4-chlorophen...

对氯肉桂酸置于1,2,3,4-四氢萘,钯体系中,化学反应 1.5H,反应生成3-(4-氯苯基)丙酸
参考文献:Synthesized Drug From Medicinal Plant Phytochemicals Effectively Targets Ecm1 Gene Mutations In Ulcerative Colitis
标题:Synthesized Drug From Medicinal Plant Phytochemicals Effectively Targets Ecm1 Gene Mutations In Ulcerative Colitis
摘要:溃疡性结肠炎(uc)是一种主要影响结肠粘膜的炎症性肠道疾病.根据其出现的方式,它可以影响整个结肠甚至远端直肠.Uc可以影响男女各年龄段的人群,但大多数患者通常在15至30岁之间出现.细胞外基质蛋白-1(ecm1)基因是一个重要的候选基因,Ecm1单核苷酸多态性的突变可能导致患者组织损伤,从而加剧由金属蛋白酶9引起的组织损伤,导致uc.在这项分析中,从中国齐鲁医院中医科学委员会获得了化合物合成的批准.选择了用作uc治疗的几种衍生物来构建药效团模型,采用基于配体的药效团建模方法进行虚拟筛选,以识别合适的药物化合物.然后在体外合成了选定的化合物,并使用分子对接技术进行验证.合成的化合物符合其他药物相似性法则的非毒性存在的所有特征.对接复合物中发现的特定交互氨基酸包括精氨酸(arg):47,赖氨酸(lys):54,苯丙氨酸(phe):141,天冬氨酸(asn):51,丝氨酸(ser):219,组氨酸(his):144,Phe:214,缬氨酸(val):220,酪氨酸(tyr):145和tyr:284.合成化合物与ecm1基因中突变的tyr:284的相互作用证实了药物分子作为溃疡性结肠炎治疗药物的可行性和安全性.未来可以在实验室中探索其有效性,并将这种合成化合物用作临床研究中针对ecm1基因中tyr:284突变的药物靶点.
Doi:10.2174/1570180818666210804130050

专利信息

专利号:WO-2021023634-A1
优先权日:2019-08-05
标 题 :PROCESS FOR THE SYNTHESIS OF PITOLISANT HCl
发明人：COLOMBANO GIAMPIERO; BARBERO MAURO; BOGOGNA LUIGI; ROLETTO JACOPO; PAISSONI PAOLO
权利人:PROCOS SPA
摘要:Disclosed is a process for the synthesis of pitolisant HCl of formula (I), from piperidine and 1-bromo-3-chloropropane. The process according to the invention is economically efficient and easily industrially scalable.

专利号:US-5001136-A
优先权日:1990-06-07
标 题 :Leukotriene-synthesis-inhibiting 2-substitutedmethylamino-5-(hydroxy or alkoxy)pyridines
发明人：WALKER FREDERICK J
权利人:PFIZER
摘要:2-substitutedmethylamino-amino 5-(hydroxy or alkoxy) pyridines and derivatives thereof are disclosed. The compounds are inhibitors of leukotriene synthesis and are therefore useful for the treatment of pulmonary, inflammatory, dermatological, allergic and cardiovascular diseases.

专利号:EP-3515880-B1
优先权日:2017-03-17
标题:Methods and compositions for synthesis of encoded libraries
发明人：LI JIN; MORGAN BARRY A; Wan jinqiao; DOU DENGFENG; LIU GUANSAI; CHANG YONG; CHEN QIUXIA; WANG XING; XU YANSHAN; HU DONGYAN; LIU JIAN; CHENG XUEMIN
权利人:HITGEN INC

专利号:US-12304894-B2
优先权日:2019-04-17
标题 :Derivatives of adamantyl oxadiazoles and pharmaceutically acceptable solvates, hydrates and salts thereof, pharmaceutical composition comprising same, synthesis method, suitable for use as effective and selective inhibitors of the reductase activity of the enzyme 11-beta dehydrogenase type 1 (11β-HSD1)
发明人：FARDELLA BELLO CARLOS ENRIQUE; LAGOS ARÉVALO CARLOS FERNANDO; VECCHIOLA CÃ?RDENAS ANDREA PAOLA; ALLENDE SANZANA FIDEL ALEJANDRO; DIETHELM VARELA BENJAMIN MANUEL; RECABARREN GAJARDO GONZALO IVAN; GONZÃ?LEZ CISTERNA PABLO MARCELO
权利人:UNIV PONTIFICIA CATOLICA CHILE
摘要:The present invention relates to compounds derived from adamantyl oxadiazoles and the pharmaceutically acceptable solvates, hydrates and salts of same. These compounds are suitable for use as effective and selective inhibitors of the reductase activity of the enzyme 11-beta dehydrogenase type 1 (11β-HSD1), as well as in the production of a drug for treating conditions and diseases such as high blood pressure, obesity, dyslipidaemia, type 2 diabetes, insulin resistance, glaucoma, metabolic syndrome, cognitive disorders, osteoporosis, immune disorders, depression and other conditions. Also provided is a pharmaceutical composition comprising the compounds and a method for preparing said composition.

专利号:US-2020149034-A1
优先权日:2017-03-17
标题:Methods and Compositions for Synthesis of Encoded Libraries

专利号:EA-002100-B1
优先权日:1996-12-23
标题:CYCLOALCYL COMPOUNDS, LACTAMS, LACTONES AND RELATED COMPOUNDS CONTAINING THEIR PHARMACEUTICAL COMPOSITIONS AND METHODS OF INHIBITING THE SURVIVAL AND / OR SYNTHESIS OF β-AMYLOUS PEPTIDE SOFTWARE AGREED SOFTWARE, SOFTWARE, SOFTWARE, SOFTWARE, SOFTWARE, SOFTWARE, SOFTWARE, SOFTWARE, SOFTWARE, SOFTWARE, SOFTWARE AND SOFTWORK