CAS: 18109-81-4; 2-[2-(Diethylamino)Ethoxy]Ethyl 2-Phenylbutanoate,2-Hydroxypropane-1,2,3-Tricarboxylic Acid
该化合物是一种主要用作止咳剂的化学化合物,被归类为抗咳剂,这意味着通过在脑中咳嗽中心采取行动有助于缓解咳嗽,该物质经常用于各种配方,包括糖浆和药片,因为其有效性和相对较低的副作用. Butamirate 柠檬酸盐因其在不引起镇静剂的情况下抑制干咳和生产性咳嗽的能力而闻名,使其成为许多超剂量咳嗽药物的首选.该化合物在口服和肝脏中代谢时一般都是很好的吸收剂.其安全性能一般是有利的,尽管与所有药物一样,它可能会对一些人产生副作用.与任何制药剂一样,在医疗专业人员的指导下使用 Butamirate 柠檬酸盐对于确保适当的剂量和避免与其他药物的潜在互动至关重要.
- 英文名称2-[2-(Diethylamino)Ethoxy]Ethyl 2-Phenylbutanoate,2-Hydroxypropane-1,2,3-Tricarboxylic Acid
- 中文名称枸橼酸布他米酯
- IUPAC名称alpha-Ethylbenzeneacetic acid, 2-(2-(diethylamino)ethoxy)ethyl ester, 2-hydroxy-1,2,3-propanetricarboxylate (1:1)
- 其它别名Butamirate citrate; diethyl[2-[2-(2-phenylbutyroyloxy)ethoxy]ethyl]ammonium dihydrogen citrate; Butamiratdihydrogencitrat; 2-(2-diethylaminoethyloxy)ethyl 2-phenylbutanoate; 2-phenylbutyric acid 2-(2-diethylaminoethyloxy)ethyl ester
- CAS编号18109-81-4
- MFCD编号:MFCD00315222
- EINECS号:242-006-8
- FDA UNII编号:67HP51L98R
- 分子式:C24H37NO10分子量:499.55128
- 产品CID: 934070
- 同类组份化合物CAS18109-80-3 (free base)18109-81-4 (citrate)
- 产品分类原料药 → 呼吸系统用药 → 镇咳药
- 相似结构搜索
- InChIKey: JVKMHUAWFDGPTF-UHFFFAOYNA-N
- JVKMHUAWFDGPTF-UHFFFAOYSA-N
- 计算化学: 氢键受体数11.0氢键供体数4.0可旋转键数17.0
物理性质
MSDS等安全信息
- GHS象形图
- GHS符号GHS07;
注释: Exclamation mark - 危险类别急性毒性 类别4(吸入)
急性毒性 类别4(经皮)
急性毒性 类别4(经口) - 警示词Warning(警告)
- 危险描述H332 |吸入有害.
H312 |皮肤接触有害.
H302 |吞咽有害. - 防范说明P264Thoroughly clean after treatmentP280Wear protective gloves/Wear protective clothing/Wear protective goggles/Wear a protective maskP305If it enters the eyesP351Rinse carefully with water for a few minutesP338Remove the contact lens(If any)And easy to operate,Continue flushingP337If eye irritation persistsP313Obtain medical advice/care
- 安全声明H303May be harmful if swallowed+H313Skin contact may be harmful+H333Inhalation may be harmful to the body
欧盟法规
ECHA物质C&L通报REACH预注册合成工艺路线路线简述
海关参考信息
- 2902600000-乙苯
2902700000-异丙基苯
2905122000-异丙醇
2905143000-叔丁醇 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-2014315720-A1
优先权日:2012-10-24
标 题 :Polysaccharide ester microspheres and methods and articles relating thereto
发明人：FALLON DENIS G; GARRETT THOMAS S; KIZER LAWTON E; ZAZZARA KAREN L; COMBS MICHAEL T; JOHNSON RICHARD K; DEHART GARY
权利人:CELANESE ACETATE LLC
摘要:A method for producing a polysaccharide ester microsphere may include forming a polysaccharide ester product from a polysaccharide synthesis, wherein the polysaccharide ester product comprises a polysaccharide ester and a solvent; diluting the polysaccharide ester product, thereby yielding a polysaccharide ester dope; and forming a plurality of polysaccharide ester microspheres from the polysaccharide ester dope. Suitable polysaccharides may include, but are not limited to, starch, cellulose, hemicellulose, algenates, chitosan, and any combination thereof. Esters thereof may be organic esters (e.g., acetate and the like), inorganic esters (e.g., sulfonates and the like), or combinations thereof. Further, the solids conent of the polysaccharide ester dope, in some instances, may be greater than about 16 wt %.
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Płusa T. [Butamirate citrate in control of cough in respiratory tract inflammation]. Pol Merkur Lekarski. 2017 Aug 21;43(254):69-74. Review. Polish. [Epub ahead of print] doi: 10.1111/bcp.12458.
4: Płusa T. [Butamyrate citrate in cough controlling]. Pol Merkur Lekarski. 2013 Dec;35(210):367-9. Review. Polish. Russian. doi: 10.1097/PEC.0b013e31827b5635. doi: 10.1002/dta.258. Epub 2011 Mar 16. doi: 10.1002/14651858.CD007881.pub2. Review. Hungarian. French. Czech. French. German. Slovak. Croatian. German.
合成参考文献
摘要:Toho Igakkai Zasshi. Journal of Medical Society of Toho University., 18(115), 1971
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