CAS: 17498-50-9; (S)-2-Amino-3-Methylbutanoic Acid Hydrochloride

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参考文献:[5-13C]-(2S,4R)-亮氨酸和[4-13C]-(2S,3S)-缬氨酸的制备和表征-建立合成方案以制备l-亮氨酸,L-异亮氨酸和l的任何定点异构体-缬氨酸
标题:[5-13C]-(2S,4R)-亮氨酸和[4-13C]-(2S,3S)-缬氨酸的制备和表征-建立合成方案以制备l-亮氨酸,L-异亮氨酸和l的任何定点异构体-缬氨酸
摘要:在本文中,开发了一种化学酶促方法,可以获取必需氨基酸异亮氨酸和缬氨酸的任何同位素.该方法正确引入了 (2S,3S)-异亮氨酸中的第二个手性中心,并允许区分缬氨酸中的两个前手性甲基,如 (2S,3S)-[4-13C] 缬氨酸的制备所示.为了制备任何同位素形式的 (2S)-亮氨酸,已使用 O'Donnell 方法来制备光学活性氨基酸.该方法中使用的受保护甘氨酸支架是通过允许访问任何同位素形式的策略制备的.[5-13C]-(2S,4R)-亮氨酸表明,O'Donnell 方法与 Evans 方法结合获得手性 2-甲基丙基碘可以很好地区分两个前手性甲基.O'Donnell 策略制备 α-氨基酸优于其他方法,因为反应条件温和,手性助剂易于回收,旋光产物易于分离.对于制备富含同位素的缬氨酸和异亮氨酸,O'Donnell 方法不适合,因为所涉及的烷基取代基具有仲卤取代基,该取代基在空间上受阻而无法与受保护的甘氨酸进行有效反应.(©
Doi:10.1002/ejoc.200300410

专利信息

专利号:US-5688968-A
优先权日:1993-03-22
标题 :Enantioselective synthesis of 5,6-dihydro-(S)-4-(ethylamino)-(S)-6-methyl-4H-thieno 2,3-B!thiopyran-2-sulfonamide 7,7-dioxide
发明人：BLACKLOCK THOMAS J; MATHRE DAVID J; SOHAR PAUL
权利人:MERCK & CO INC
摘要:A key step in the synthesis of 5,6-dihydro-(S)-4-(ethylamino)-(S)-6-methyl-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide (dorzolamide) and related compounds is a Ritter reaction with an unexpected tendency to proceed with retention of chirality.

专利号:US-4518813-A
优先权日:1981-10-02
标 题:Optically active units for the synthesis of the side chain of (R,R,R)-α-tocopherol and their preparation
发明人：ERNST HANSGEORG; VOGEL FRIEDRICH; PAUST JOACHIM
权利人:BASF AG
摘要:(2R,6R)-1-Chloro-2,6,10-trimethyl-undecane I, (R)-(+)-β-chloro-isobutyric acid II, (S)-(+)-1-bromo-3-chloro-2-methylpropane IV and (2R)-(+)-1-chloro-2,6-dimethyl-heptane V are novel optically active units for the synthesis of the side chain of (R,R,R)-α-tocopherol. In the process according to the invention, the optically active C 14 -chloride I is obtained in 6 simple reaction steps starting from II, via the novel intermediates IV and V, in accordance with the following equation: ##STR1##

专利号:US-6448058-B1
优先权日:1997-09-12
标 题:Methods for solid phase synthesis of mercapto compounds and derivatives, combinatorial libraries thereof and compositions obtained thereby
发明人：PATEL DINESH V; NGU KHEHYONG; ZHOU JIANPING
权利人:VERSICOR INC
摘要:Methods of preparing combinatorial libraries of mercapto (thiol) compounds them and compositions obtained therefrom are disclosed. The compounds are synthesized on a solid support. Following synthesis, the compounds are optionally cleaved from the support. One such method of synthesis involves attack of an S-protected nucleophile on a resin functionalized with a leaving group. The invention also provides for screening the mercapto compounds for bioactive compounds; in particular, for inhibitors of MMPs.

专利号:US-8299250-B2
优先权日:2007-10-18
标题:Chiral tridentate compounds, corresponding organometal complexes, method for preparing same and use of said compounds and complexes as ligands in asymmetrical catalysis
发明人：MAUDUIT MARC; RIX DIANE; CREVISY CHRISTOPHE; WENCEL JOANNA
权利人:MAUDUIT MARC; RIX DIANE; CREVISY CHRISTOPHE; WENCEL JOANNA; ECOLE NALE SUP ARTES METIERS; CENTRE NAT RECH SCIENT
摘要:The invention relates to a compound of the formula (I) or the formula (II) in which: W is an oxygen atom or a radical of the formula NH; X is hydrogen or an alkaline cation or a C1-C8 alkyl or a —(CH 2 ) n 3 —C(R 4 )(R 5 )(R 6 ) radical; X and R on the one hand and X and R 1 on the other hand may independently form an optionally substituted cycle with 5, 6 or 7 links. The invention also relates to complexes of said compounds with at least one metal selected from the group comprising copper, palladium, ruthenium, iridium and rhodium, and to a method for the synthesis of these compounds. These compounds and complexes can be used in various asymmetrical catalysis methods.

专利号:US-6281245-B1
优先权日:1996-10-28
标 题:Methods for solid-phase synthesis of hydroxylamine compounds and derivatives, and combinatorial libraries thereof
发明人：PATEL DINESH V; NGU KHEHYONG
权利人:VERSICOR INC
摘要:A novel method for generating hydroxylamine, hydroxamic acid, hydroxyurea, and hydroxylsulfonamide compounds is disclosed. The method involves the nucleophilic attack of an alkoxyamine on a suitable solid phase support. Techniques of combinatorial chemistry can then be applied to the immobilized alkoxyamine to generate a diverse set of compounds. Cleavage of the compounds from the support yields a library of hydroxylamine or hydroxylamine derivative compounds, which can be screened for biological activity (e.g., inhibition of metalloproteinases).

专利号:US-6541276-B2
优先权日:1996-10-28
标题:Methods for solid-phase synthesis of hydroxylamine compounds and derivatives and combinatorial libraries thereof
发明人：PATEL DINESH V; NGU KHEHYONG
权利人:VERSICOR INC
摘要:A novel method for generating hydroxylamine, hydroxamic acid, hydroxyurea, and hydroxylsulfonamide compounds is disclosed. The method involves the nucleophilic attack of an alkoxyamine on a suitable solid phase support. Techniques of combinatorial chemistry can then be applied to the immobilized alkoxyamine to generate a diverse set of compounds. Cleavage of the compounds from the support yields a library of hydroxylamine or hydroxylamine derivative compounds, which can be screened for biological activity (e.g., inhibition of metalloproteases).