CAS: 16694-18-1; 4-Bromo-2-Thiophenecarboxylic Acid

相似化合物

18791-75-8 62224-16-2 62224-17-3

上下游产品

2,4-dibromothiophene n-butyllithium diethyl ether methylammonium carbonate 3-Bromothiophene 4-bromothiophene-2-carboxylic acid methyl ester 4-Bromothiophene-2-carboxylic acid chloride 4-[4-(trifluoromethoxy)phenyl]thiophene-2-carboxylic acid

4,5-二溴噻吩-2-甲酸置于溶剂黄146,锌体系中,用 水 用作溶剂,化学反应 0.25H,以90%的收率获得4-溴噻吩-2-甲酸
参考文献:Binder,Dieter; Prager,Bernhard C.; Noe,Christian R.,Journal Of Chemical Research,Miniprint,1981,# 5,P. 1801-1824
标题:Binder,Dieter; Prager,Bernhard C.; Noe,Christian R.,Journal Of Chemical Research,Miniprint,1981,# 5,P. 1801-1824

专利信息

专利号:CN-104284891-A
优先权日:2012-03-17
标 题:Conformational Restricted Total Synthesis of Macrocyclic Compounds

专利号:US-10017481-B2
优先权日:2012-03-17
标 题 :Conformationally constrained, fully synthetic macrocyclic compounds
发明人：OBRECHT DANIEL; ERMERT PHILIPP; OUMOUCH SAID; PIETTRE ARNAUD; GOSALBES JEAN-FRANÇOIS; THOMMEN MARC
权利人:POLYPHOR AG
摘要:The conformationally restricted, spatially defined macrocyclic ring system of formula (I) is constituted by three distinct molecular parts: Template A, conformation Modulator B and Bridge C. Macrocycles described by this ring system I are readily manufactured by parallel synthesis or combinatorial chemistry in solution or on solid phase. They are designed to interact with a variety of specific biological target classes, examples being agonistic or antagonistic activity on G-protein coupled receptors (GPCRs), inhibitory activity on enzymes or antimicrobial activity. In particular, these macrocycles show inhibitory activity on endothelin converting enzyme of subtype 1 (ECE-1) and/or the cysteine protease cathepsin S (CatS), and/or act as antagonists of the oxytocin (OT) receptor, thyrotropin-releasing hormone (TRH) receptor and/or leukotriene B4 (LTB4) receptor, and/or as agonists of the bombesin 3 (BB3) receptor, and/or show antimicrobial activity against at least one bacterial strain. Thus they are showing great potential as medicaments for a variety of diseases.