CAS: 13139-28-1; (S)-Benzyl (1-Amino-3-Methyl-1-Oxobutan-2-yl)Carbamate

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📜L-缬氨酸盐酸盐置于氯甲酸乙酯,Sodium Carbonate,三乙胺体系中,用 四氢呋喃,水 用作溶剂,化学反应 19.0H,反应生成Cbz-L-缬氨酰胺
参考文献: Peptidomimetic Compounds And Antibody-Drug Conjugates Thereof[fr] Composés Peptidomimétiques Et Conjugués Anticorps-Médicament De Ceux-Ci
标题: Peptidomimetic Compounds And Antibody-Drug Conjugates Thereof[fr] Composés Peptidomimétiques Et Conjugués Anticorps-Médicament De Ceux-Ci

专利信息

专利号:US-4028315-A
优先权日:1970-10-16
标题:Solid phase synthesis of peptides
发明人：BODANSZKY MIKLOS; SHEEHAN JOHN TIMOTHY
权利人:SQUIBB & SONS INC
摘要:A process for bonding an amino acid to an insoluble hydroxymethyl polymer by esterifying the C-terminal carboxyl group of an N-terminal protected amino acid with the hydroxyl group of an insoluble hydroxymethyl polymer. The esterifying takes place at about room temperature in the presence of a condensing agent. The insoluble hydroxymethyl polymer is a hydroxymethylated copolymer of styrene and divinylbenzene, hydroxymethylcellulose, hydroxymethylated sulfonated polystyrene or polyvinyl alcohol. The condensing agent is dicyclohexylcarbodiimide, carbonyldiimidazole, thionyl chloride, phosphorous oxychloride or ethoxyacetylene. Peptides can be formed by bonding one or more amino acids to the amino acid bonded to the insoluble hydroxymethyl polymer.