CAS: 1269026-22-3; Ethyl 6-Bromo-3-Hydroxy-5-Methylpyrazine-2-Carboxylate

相似化合物

21874-61-3 141872-22-2 859064-08-7

上下游产品

3-羟基-5-甲基吡嗪-2-羧酸乙酯 Ethyl 3-Hydroxy-5-Methylpyrazine-2-Carboxylate 141872-22-2

📜酮基丙二酸二乙酯置于n-溴代丁二酰亚胺(Nbs)体系中,用 乙醇,N,N-二甲基甲酰胺 用作溶剂,化学反应 23.0H,反应生成6-溴-5-甲基-3-氧代-3,4-二氢吡嗪-2-羧酸乙酯
参考文献: Pyrrolopyrazole Spiro Compound[fr] Composé Spiro De Pyrrolopyrazole[zh] 吡咯并吡唑螺环化合物
标题: Pyrrolopyrazole Spiro Compound[fr] Composé Spiro De Pyrrolopyrazole[zh] 吡咯并吡唑螺环化合物
摘要:公开了一类吡咯并吡唑螺环化合物,及其在制备治疗相关疾病的药物中的应用,具体涉及式(I')化合物,其立体异构体及其药学上可接受的盐.

专利信息

专利号:US-2024239799-A1
优先权日:2021-04-02
标 题:(s)-1-(5-((pyridin-3-yl)thio)pyrazin-2-yl)-4'h,6'h-spiro[piperidine-4,5'-pyrrolo [1,2-b]pyrazol]-4'-amine derivatives and similar compounds as shp2 inhibitors for the treatment of e.g. cancer
发明人：DI FABIO ROMANO; MONTALBETTI CHRISTIAN; PETROCCHI ALESSIA; GRILLO ALESSANDRO; RANDAZZO PIETRO; ROSSETTI ILARIA; CIAMMAICHELLA ALINA
权利人:C N C C S S C A R L COLLEZIONE NAZ DEI COMPOSTI CHIMICI E CENTRO SCREENING; IRBM S P A
摘要:The present invention relates to compounds of formula (I). The compounds of the formula (I) are e.g. (S)-1-(5-((pyridin-3-yl)thio) pyrazin-2-yl)-41H,6′H-spiro[piperidine-4,5′-pyrrolo[1,2-b]pyrazol]-41-amine derivatives and similar compounds. The present invention also relates to the compounds of formula (I) for use as Src homology phosphotyrosine phosphatase 2 (SHP2) inhibitors in methods of treatment of e.g. cancer, cardiovascular diseases, immunological disorders, autoimmune disorders, fibrosis, ocular disorders, systemic lupus erythematosus, diabetes, neutropenia, and combinations thereof. The present invention also relates to pharmaceutical compositions containing said compounds and to their methods of synthesis.