CAS: 121177-82-0; 4-(N-Methylaminocarbonyl)Phenylboronic Acid

相似化合物

214360-57-3 252663-47-1 123088-59-5

上下游产品

4-羧基苯硼酸 4-Carboxyphenylboronic Acid 14047-29-1
4-甲酰氯苯硼酸 (4-(Chlorocarbonyl)Phenyl)Boronic Acid 332154-57-1
4-甲氧羰基苯硼酸 4-Methoxycarbonylphenylboronic Acid 99768-12-4

4-羧基苯硼酸置于草酰氯,N,N-二异丙基乙胺,N,N-二甲基甲酰胺体系中,用 二氯甲烷 用作溶剂,化学反应 2.0H,反应生成4-(N-甲基甲酰氨)苯基硼酸
参考文献: Compound And Use Thereof In Preparation Of Bcl-Xl Inhibitor[fr] Composé Et Son Utilisation Dans La Préparation D'Un Inhibiteur De Bcl-Xl[zh] 一种化合物及其在制备bcl-Xl抑制剂中的用途
标题: Compound And Use Thereof In Preparation Of Bcl-Xl Inhibitor[fr] Composé Et Son Utilisation Dans La Préparation D'Un Inhibiteur De Bcl-Xl[zh] 一种化合物及其在制备bcl-Xl抑制剂中的用途
摘要:本发明公开了一种化合物及其在制备bcl-Xl抑制剂中的用途,属于制药领域.本发明提供的化合物结构如式i所示,该化合物可以有效结合bcl-Xl蛋白,从而进一步抑制bcl-Xl蛋白的活性.本发明化合物能够用于制备bcl-Xl抑制剂,以及预防和/或治疗与bcl-Xl蛋白活性有关疾病(例如癌症,自身免疫性疾病等)的药物,临床应用前景广阔.本发明化合物具有非常好的药理学特性,其稳定性好,成药可能性高,并且该化合物制备方法简单,产率高,成本低,适合工业化生产.

专利信息

专利号:US-2023212216-A1
优先权日:2019-12-20
标 题:Synthesis of lactone derivatives and their use in the modification of proteins
发明人：MORRIS ALEXANDER REDFERN; SUTOV GRIGORIJ; BRUNE KARL DIETRICH
权利人:GENIE BIOTECH UK LTD
摘要:Site-specific modifications of proteins are desirable in biotechnological applications such as biopharmaceuticals, immunotherapy, vaccines, and are useful in chemical biology. Gluconoylation is a non-enzymatic, covalent, post-translational modification commonly observed on N-terminal His-Tags bearing proteins. We synthesized glucono-1,5-lactone derivatives, including azido variants for selective acylation. High yield acylation is achieved by simply mixing derivatives with target protein amidst diverse conditions of temperatures, aqueous buffers, excipients, or complex cell lysate.

专利号:US-2022411860-A1
优先权日:2015-09-28
标题:Design and synthesis of novel disulfide linker based nucleotides as reversible terminators for dna sequencing by synthesis

专利号:US-2023160000-A1
优先权日:2015-09-28
标 题:Synthesis of novel disulfide linker based nucleotides as reversible terminators for dna sequencing by synthesis

专利号:US-2023028388-A1
优先权日:2015-09-28
标 题 :Design and synthesis of novel disulfide linker based nucleotides as reversible terminators for dna sequencing by synthesis

专利号:US-11085076-B2
优先权日:2015-09-28
标 题 :Synthesis of novel disulfide linker based nucleotides as reversible terminators for DNA sequencing by synthesis

专利号:AU-2020409711-A1
优先权日:2019-12-20
标题 :Synthesis of lactone derivatives and their use in the modification of proteins