CAS: 68194-06-9; 2,2',4,5,6'-Pentachlorobiphenyl
该化合物是多氯联苯(PCB)家族的成员,该家族由多氯替代物组成的双联苯分子组成,该化合物的五个氯原子附于双联结构,大大改变了其物理和化学特性,在室温和热能稳定性和降解抗药性方面通常是固体.2,2',4,4,5,6'-Penta-氯联苯具有水分,这意味着水溶性较低,但可溶于有机溶剂中,化学稳定性和亲性促使其在环境中的持久性,导致生物生物体生物累积,该化合物在各种工业应用中使用,包括电气设备和热传导液,但由于众所周知多氯联苯具有毒性和潜在致癌性,因此其使用主要限于环境和健康关切.
- 相似结构搜索
- 产品信息参考
;;;; - InChIKey: BWWVXHRLMPBDCK-UHFFFAOYSA-N
- 1S/C12H5Cl5/c13-7-2-1-3-8(14)12(7)6-4-10(16)11(17)5-9(6)15/h1-5H
- 计算化学: 氢键受体数*氢键供体数0.0可旋转键数1.0
MSDS等安全信息
- 危险描述Not Classified
Reported as not meeting GHS hazard criteria by 3 of 3 companies. For more detailed information, please visit ECHA C&L website. - 安全声明The mechanism of action varies with the specific PCB. Dioxin-like PCBs bind to the aryl hydrocarbon receptor, which disrupts cell function by altering the transcription of genes, mainly be inducing the expression of hepatic Phase I and Phase II enzymes, especially of the cytochrome P450 family. Most of the toxic effects of PCBs are believed to be results of Ah receptor binding. Other PBCs are believed to interfere with calcium channels and/or change brain dopamine levels. PCBs can also cause endocrine disurption by altering the production of thyroid hormones and binding to estrogen receptors, which can stimulate the growth of certain cancer cells and produce other estrogenic effects, such as reproductive dysfunction. They will bioaccumulate by binding to receptor proteins such as uteroglobin. (A3, A4, A30, A66)
上下游产品
1,3-dichloro-2-iodobenzene 2,4,5-trichloroiodobenzene合成工艺路线路线简述
📜1,3-二氯-2-碘苯,1-碘-2,4,5-三氯苯置于铜体系中,用 N,N-二甲基甲酰胺 作为反应溶剂,化学反应生成 2,2',4,5,6'-五氯联苯
参考文献:Physical,Spectral And Chromatographic Properties Of All 209 Individual Pcb Congeners
标题:Physical,Spectral And Chromatographic Properties Of All 209 Individual Pcb Congeners
摘要:Physical,Spectral And Chromatographic Data For All 209 Individual Pcb Congeners Is Presented. The Individual Congeners Were Synthesized And Then Isolated And Purified. Recent Emphasis On The Source Of The Toxicity Of Commercial Pcb Formulations Has Increased The Need For A Complete Set Of The Pcb Congeners. Through The Use Of Two Capillary Gc Columns: 40% octadecyl/ 15% Phenyl Methyl Siloxane And 50% Phenyl Methyl Siloxane,It Was Possible To Separate 201 Pcb Congeners With Only Four Unresolved Pairs. The Data Compiled In This Study For All 209 Congeners Will Aid In The Identification Of Selected Individual Components Of These Environmental Pollutants. The Use Of This Data Also Presents The Opportunity For The Improved Quantification Of The Commercial Pcb Formulations.
DOI:10.1016/0045-6535(95)00140-4
海关参考信息
- 2903911000-邻二氯苯
- 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
供应商参考报价(招募中)
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📌 第三方产品分析报告
合成参考文献
摘要:T14: Lewis RJ (1996). Sax's Dangerous Properties of Industrial Materials. 9th ed. Volumes 1-3. New York, NY: Van Nostrand Reinhold.
摘要:L4: ATSDR - Agency for Toxic Substances and Disease Registry (2000). Toxicological profile for polychlorinated biphenyls. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).
摘要:L134: ATSDR - Agency for Toxic Substances and Disease Registry (2001). Minimal Risk Levels (MRLs) for Hazardous Substances. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).
摘要:L135: International Agency for Research on Cancer (2014). IARC Monographs on the Evaluation of Carcinogenic Risks to Humans.
摘要:T6: World Health Organization (1993). Environ Health Criteria 140: Polychlorniated Biphenyls and Terphenyls.
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