CAS: 635705-72-5; (S)-4-Amino-2-(1-(3-Ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl)Ethyl)Isoindoline-1,3-Dione
该化合物是Aprimilast(一种磷柴油酶4(PDE4)抑制剂)的衍生物,主要用于制药研究,作为合成亚丙米拉斯和相关化合物的参考标准或中间体;该化合物保留亚丙酰甲状腺的核心结构,但缺乏可能影响其药用动力学和药用动力学特性的乙酰基.
- 英文名称(S)-4-Amino-2-(1-(3-Ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl)Ethyl)Isoindoline-1,3-Dione
- 中文名称阿普斯特杂质 03
- IUPAC名称(S)-4-amino-2-(1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)isoindoline-1,3-dione
- 其它别名Apst-Za; 4-Amino-2-[(1S)-1-(3-Ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl)Ethyl]-1H-Isoindole-1,3(2H)-Dione; Apremilast N-Desacetyl Impurity; Apremilast Impurity P; Apremilast Impurity And; Des-Acetyl Apremilast; Apremilast N-Desacetyl Imurity; 1H-Isoindole-1,3(2H)-Dione, 4-Amino-2-[(1S)-1-(3-Ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl)Ethyl]-
- CAS编号635705-72-5
- MFCD编号:MFCD22543850
- FDA UNII编号:FU766G6PHK
- 分子式:C20H22N2O6S分子量:418.47
- 产品CID: 2532828
- 产品分类分析化学 → 标准品 → 药典标准品和杂质标准品
物理性质
MSDS等安全信息
上下游产品
2-(3-ethoxy-4-methoxyphenyl)-1-(methylsulfonyl)eth-2-ylamine (S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine-(S)-2-acetamido-4-methylpentanoate 3-aminophthalic acid (S)-2-[1 (3-ethoxy-4-methoxyphenyl)]-1-methanesulfonyl-2-ethylamine(1S)-2-benzyloxy-N-{2-[1-(3-ethoxy-4-methoxy-phenyl)-2-methanesulfonyl-ethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}-acetamide (S)-4-Amino-2-[1-(3,4-dihydroxy-phenyl)-2-methanesulfonyl-ethyl]-isoindole-1,3-dione (S)-N-{2-[1-(3-ethoxy-4-hydroxy-phenyl)-2-methanesulfonyl-ethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}-2-hydroxy-acetamide (S)-N-{2-[1-(3,4-dihydroxy-phenyl)-2-methanesulfonyl-ethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}-2-hydroxy-acetamide合成工艺路线路线简述
📜阿普斯特置于盐酸体系中,用 甲醇 作为反应溶剂,以8 G的收率获得产物阿普斯特降解杂质
参考文献: Process For Preparation Of Apremilast[fr] Procédé De Préparation D'Aprémilast
标题: Process For Preparation Of Apremilast[fr] Procédé De Préparation D'Aprémilast
摘要:本发明涉及一种制备阿普利莫司特的方法.本发明涉及阿普利莫司特的对二甲苯溶剂结晶体以及其制备方法.
海关参考信息
- 2902600000-乙苯
2907210001-间苯二酚
2912110000-甲醛
2912210000-苯甲醛 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
参考标题:Asymmetric Synthesis Of β-Aryl β-Imido Sulfones Using Rhodium Catalysts With Chiral Diene Ligands: Synthesis Of Apremilast作者:Jin-Fong Syu,Balraj Gopula,Jia-Hong Jian,Wei-Sian Li,Ting-Shen Kuo,Ping-Yu Wu,Julian P. Henschke,Meng-Chi Hsieh,Ming-Kang Tsai,Hsyueh-Liang Wu |发布日期:2019.6.21
摘要:A Chiral Rhodium(I)-Diene Catalyst Enabled The One-Step Synthesis Of β-Aryl β-Imido Sulfones Under Mild Reaction Conditions. By Selection Of The Chiral Diene Ligand L1A Or L2, Each Enantiomer Of The Chiral β-Aryl β-Imido Sulfone Target Can Be Accessed With High Stereoselectivity. Demonstration Of The Scope Of The Reaction, Which Includes The Synthesis Of An N-Protected Chiral β-Amino β-Phenyl Sulfone
合成参考文献
摘要:S113 | SWISSPHARMA24 | 2024 Swiss Pharmaceutical List with Metabolites | DOI:10.5281/zenodo.10501043
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