CAS: 55346-97-9; 4,5-Difluoro-2-Nitrophenol

上下游产品

3,4-difluorophenol tert-butyl 4-(2-fluoro-5-hydroxy-4-nitrophenyl)piperazine-1-carboxylate 1,2-difluoro-4-methoxy-5-nitro-benzene 1-(1-(2-Fluoro-5-methoxy-4-nitrophenyl)piperidin-4-yl)-4-methylpiperazine 5-Fluoro-2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)aniline

3,4-二氟苯酚置于硝酸,溶剂黄146体系中,化学反应 2.0H,反应生成 2,3-二氟-6-硝基苯酚
参考文献:发现具有gpr120选择性激动剂的铬丙酸类似物,在啮齿动物中具有体内活性.
标题:发现具有gpr120选择性激动剂的铬丙酸类似物,在啮齿动物中具有体内活性.
摘要:Gpr120(ffar4)是脂肪酸敏感的g蛋白偶联受体(gpcr),已被确定为可能治疗2型糖尿病的靶标.体内设计,合成和评估了含有苯并二氢吡喃骨架的gpr120选择性激活剂.这些努力的结果表明,苯丙氨酸丙酸18是用于进一步动物研究的合适工具分子.化合物18在紧密相关的靶标gpr40(ffar1)上具有选择性,具有干净的脱靶谱,显示合适的药代动力学特性,并已在野生型/基因敲除gpr120小鼠ogtt研究中进行了评估.
DOI:10.1021/acsmedchemlett.6B00394

专利信息

专利号:WO-2024041503-A1
优先权日:2022-08-22
标 题:Compounds targeting y220c mutant of p53
发明人：LI SUJING; LI AMIN; ZHENG QIAN; Dang Chaojie; FAN XINRUI; LONG WEI; WANG YANPING
权利人:JACOBIO PHARMACEUTICALS CO LTD
摘要:The present invention discloses compounds of formula (I) which can bind to mutant p53 and restore the ability of the p53 mutant to bind DNA and activate downstream effectors involved in tumor suppression. Also provided are processes for the synthesis and use of the compounds of formula (I).

专利号:RU-2744784-C1
优先权日:2017-03-28
标题:Benzoxazine-oxazolidinone compound displaced by a nitrogen-containing heterocycle, method of synthesis and application thereof