CAS: 51908-16-8; 2,2',3,4',5,5'-Hexachlorobiphenyl

该化合物是多氯联苯(PCB)家族的成员,是合成有机化学品,以其环境持久性和潜在毒性而著称;该化合物的六氯原子代之以双苯结构,这大大改变了其物理和化学特性;该化合物一般在室内温度下是固体,具有低挥发性,因此具有抗降解的抗药性;多种氯原子的存在会加剧其疏水性,导致生物体中的生物累积,并可能导致食物链中的生物放大作用. 2,2',3,4',5,5'-六氯联苯的稳定性和对化学反应的抗药性是众所周知的,有助于其在环境中的寿命;然而,由于人们对其毒性,包括潜在的致癌影响和内分泌干扰等原因,许多国家限制或禁止使用该物质.目前正在开展监测和补救工作,以解决与这一化合物和其他多氯联苯化合物有关的环境和健康影响.

英文名称2,2',3,4',5,5'-Hexachlorobiphenyl
中文名称2,2',3,4',5,5'-六氯联苯
IUPAC名称1,2,4-trichloro-5-(2,3,5-trichlorophenyl)benzene
CAS编号51908-16-8
MFCD编号:MFCD00792637
FDA UNII编号:8EZ9BWE16M
分子式:C12H4Cl6分子量:360.88
产品CID: 1509852
产品分类分析化学 → 食品安全 → 二噁英，多氯联苯，呋喃

相似结构搜索
产品信息参考;;;;
InChIKey: BQHCQAQLTCQFJZ-UHFFFAOYSA-N
1S\/C12H4Cl6\/c13-5-1-7(12(18)11(17)2-5)6-3-9(15)10(16)4-8(6)14\/h1-4H
计算化学: 氢键受体数*氢键供体数0.0可旋转键数1.0

MSDS等安全信息

危险描述Not Classified
Reported as not meeting GHS hazard criteria by 3 of 3 companies. For more detailed information, please visit ECHA C&L website.
安全声明The mechanism of action varies with the specific PCB. Dioxin-like PCBs bind to the aryl hydrocarbon receptor, which disrupts cell function by altering the transcription of genes, mainly be inducing the expression of hepatic Phase I and Phase II enzymes, especially of the cytochrome P450 family. Most of the toxic effects of PCBs are believed to be results of Ah receptor binding. Other PBCs are believed to interfere with calcium channels and/or change brain dopamine levels. PCBs can also cause endocrine disurption by altering the production of thyroid hormones and binding to estrogen receptors, which can stimulate the growth of certain cancer cells and produce other estrogenic effects, such as reproductive dysfunction. They will bioaccumulate by binding to receptor proteins such as uteroglobin. (A3, A4, A30, A66)

上下游产品

2,4,5-trichloroaniline 1,2,4-Trichlorobenzene

合成工艺路线路线简述

📜2,2',3,4,4',5,5'-七氯联苯反应生成 2,2',3,4',5,5'-六氯联苯
参考文献:Duebelbeis,D. O.;Kapila,S.;Clevenger,T.;Yanders,A. F.;Manahan,S. E.,Chemosphere,18,(1989) N-6,C. 101-108
标题:Duebelbeis,D. O.;Kapila,S.;Clevenger,T.;Yanders,A. F.;Manahan,S. E.,Chemosphere,18,(1989) N-6,C. 101-108