CAS: 4616-63-1; 2-(Prop-2-Yn-1-Yloxy)Isoindoline-1,3-Dione

上下游产品

CAS号524-38-9 N-羟基邻苯二甲酰亚胺 | CAS号106-96-7 溴代丙炔 | CAS号590-17-0 溴乙腈 | CAS号107-19-7 丙炔醇 | CAS号463-49-0 丙二烯 | CAS号21663-79-6 O-(丙-2-炔-1-基)羟胺盐酸盐 | CAS号74484-67-6 1H-Isoindole-1,... | CAS号74484-69-8 2-[4-(azepan-1-... | CAS号74484-70-1 2-[4-(az°Can-1-... | CAS号4616-54-0 O-2-丙炔羟胺

📜N-羟基邻苯二甲酰亚胺,2-丙炔-1-醇置于三苯基膦,偶氮二甲酸二乙酯体系中,用 四氢呋喃 作为反应溶剂,化学反应 20.0H,以73%的收率获得产物n-炔丙基氧基酞亚胺
参考文献: Novel Orally Bioavailable Breathing Control Modulating Compounds,And Methods Of Using Same[fr] Nouveaux Composés De Modulation De Régulation De La Respiration Oralement Biodisponibles Et Leurs Procédés D'Utilisation
标题: Novel Orally Bioavailable Breathing Control Modulating Compounds,And Methods Of Using Same[fr] Nouveaux Composés De Modulation De Régulation De La Respiration Oralement Biodisponibles Et Leurs Procédés D'Utilisation

专利信息

专利号:US-7109377-B2
优先权日:1996-10-16
标 题:Synthesis of combinatorial libraries of compounds reminiscent of natural products
发明人：SCHREIBER STUART L; SHAIR MATTHEW D; TAN DEREK S; FOLEY MICHAEL A; STOCKWELL BRENT R
权利人:HARVARD COLLEGE
摘要:The present invention provides complex compounds reminiscent of natural products and libraries thereof, as well as methods for their production. The inventive compounds and libraries of compounds are reminiscent of natural products in that they contain one or more stereocenters, and a high density and diversity of functionality. In general, the inventive libraries are synthesized from diversifiable scaffold structures, which are synthesized from readily available or easily synthesizable template structures. In certain embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from a shikimic acid based epoxyol template. In other embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from the pyridine-based template isonicotinamide. The present invention also provides a novel ortho-nitrobenzyl photolinker and a method for its synthesis. Furthermore, the present invention provides methods and kits for determining one or more biological activities of members of the inventive libraries. Additionally, the present invention provides pharmaceutical compositions containing one or more library members.

专利号:US-9988492-B2
优先权日:2013-09-30
标题:Methods for post-fabrication functionalization of poly(ester ureas)
发明人：BECKER MATTHEW; LIN FEI
权利人:BECKER MATTHEW; LIN FEI; UNIV AKRON
摘要:Amino acid-based poly(ester urea)s (PEU) are emerging as a class of polymers that have shown promise in regenerative medicine applications. Embodiments of the invention relate to the synthesis of PEUs carrying pendent “clickableâ€? groups on modified tyrosine amino acids. The pendent species include alkyne, azide, alkene, tyrosine-phenol, and ketone groups. PEUs with M w exceeding 100k Da were obtained via interfacial polycondensation methods and the concentration of pendent groups was varied by copolymerization. The incorporation of derivatizable functionalities is demonstrated using 1 H NMR and UV-Vis spectroscopy methods. Electrospinning was used to fabricate PEU nanofibers with a diameters ranging from 350 nm to 500 nm. The nanofiber matricies possess mechanical strengths suitable for tissue engineering (Young's modulus: 300±45 MPa; tensile stress: 8.5±1.2 MPa). A series of bioactive peptides and fluorescent molecules were conjugated to the surface of the nanofibers following electrospinning using bio-orthogonal reactions in aquous media.

专利号:US-2003082830-A1
优先权日:1996-10-16
标 题:Synthesis of combinatorial libraries of compounds reminiscent of natural products

专利号:WO-0006525-A9
优先权日:1998-07-25
标题:Synthesis of combinatorial libraries of compounds reminiscent of natural products

专利号:WO-0006525-A2
优先权日:1998-07-25
标 题:Synthesis of combinatorial libraries of compounds reminiscent of natural products

专利号:US-6448443-B1
优先权日:1996-10-16
标 题:Synthesis of combinatorial libraries of compounds reminiscent of natural products