CAS: 41107-82-8; 2,5-Anhydro-D-Mannitol
该化合物是一种甘醇,是曼诺斯衍生物,其特点是晶体结构,典型为白色至非白色固体,该化合物在水中溶解,具有甜味,对食品和制药应用感兴趣,其分子式为C6H12O6,其分子重量反映其碳,氢和氧原子的构成. 2,5-Anhy-D-manniotol在不同条件下具有稳定性,由于其含热量低,经常被用作糖的替代品.此外,该化合物在药物运载系统的配制和生物配方中具有潜在用途,还因其在代谢途径中的作用而得到承认,并可以参与其他碳水化合物的合成.
- 英文名称2,5-Anhydro-D-Mannitol
- 中文名称2,5-脱水-D-甘露醇
- IUPAC名称(2R,3S,4S,5R)-2,5-bis(hydroxymethyl)tetrahydrofuran-3,4-diol
- 其它别名2,5-Anhydro-D-Mannitol; 2,5-Anhydromannitol; (2R,3S,4S,5R)-2,5-Bis(Hydroxymethyl)Oxolane-3,4-Diol; 2,5-Anhydro-D-Mannitol, Min. ; (2R,3S,4S,5R)-2,5-Bis(Hydroxymethyl)Tetrahydrofuran-3,4-Diol; 2,5-Bis(Hydroxymethyl)Oxolane-3,4-Diol; D-Mannitol, 2,5-Anhydro-; (2R)-3β,4α-Dihydroxytetrahydrofuran-2α,5β-Bismethanol
- CAS编号41107-82-8
- MFCD编号:MFCD00012443
- EINECS号:255-221-7
- FDA UNII编号:W5DLZ1WC4B
- 分子式:C6H12O5分子量:164.16
- 产品CID: 1425354
- 产品分类生物化工 → 糖类化合物 → 单糖
物理性质
- 熔点100-103 °C
- 沸点416.2±35.0 °C at 760 mmHg
- 闪点205.5±25.9 °C
- 密度1.5±0.1 g/cm3
- PH:56.7 º (c=1, H2O 19 °C)
- pKa:13.26±0.70(预测)
- PSA:90.15
- LogP:-1.35
- 旋光度56.7º(C=1,H2O19ºC)
- 折射率1.557
- 蒸汽压0.0±2.2 mmHg at 25°C
- 溶解性Methanol (Slightly), Water (Slightly)
- 敏感性遵照规定使用和储存则不会分解。
- 外观形态白色至类白色固体
- 储存条件2-8°C
- 产品应用该化合物用于三甘酸盐进入高压导体的乳酸酯加火压酸盐和基质的葡萄化物的生成.
MSDS等安全信息
欧盟法规
ECHA物质C&L通报REACH预注册上下游产品
CAS号50-70-4 山梨醇 | CAS号102208-55-9 2,5-anhydro-3,4... | CAS号495-75-0 2,5-脱水-d-甘露糖 | CAS号65729-88-6 2,5-Anhydro-D-m... | CAS号1941-50-0 D-Arabinose, di... | CAS号228862-97-3 1-氨基-2,5-脱水-1-脱...合成工艺路线路线简述
- 合成目标产物 2,5-Anhydro-D-Mannitol 主要起始原料 2,5-Anhydro-D-Mannose
- (文献来源)合成步骤主要原料 2,5-Anhydro-D-Mannose
📜D-氨基葡萄糖盐酸盐置于platinum On Activated Charcoal 盐酸,氢气,Sodium Nitrite体系中,化学反应生成 2,5-脱水-D-甘露醇
参考文献:2,5-脱水-D-己糖醇:2,5-脱水-D-麦芽糖醇和2,5-脱水-D-己糖醇的合成
标题:2,5-脱水-D-己糖醇:2,5-脱水-D-麦芽糖醇和2,5-脱水-D-己糖醇的合成
摘要:摘要由2,5-脱水-D-甘露糖醇(1A)制备了2,5-脱水-D-麦芽糖醇(2A)和先前未知的2,5-脱水-D-麦芽糖醇(3A).由中间体环氧化物7B制备3A对ph特别敏感,并提出了解释该ph的机理.请注意三环过氧乙酸-磷酸氢二钠方法对反应性降低的烯烃进行环氧化的局限性.
DOI:10.1016/0008-6215(84)85086-7
海关参考信息
- 2905122000-异丙醇
2905310000-1,2-乙二醇
2905320000-1,2-丙二醇
2905399001-1,3-丙二醇 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-11203772-B2
优先权日:2010-12-23
标题:Chemoenzymatic synthesis of structurally homogeneous ultra-low molecular weight heparins
发明人：XU YONGMEI; LIU JIAN
权利人:XU YONGMEI; LIU JIAN; UNIV NORTH CAROLINA CHAPEL HILL
摘要:Methods for preparing synthetic heparins are provided. Synthetic heparin compounds, including ultralow molecular weight heparin compounds are provided. Also provided are methods of chemoenzymatically synthesizing structurally homogeneous ultra-low molecular weight heparins. Heparin compounds provided herein can have anticoagulant activity.
专利号:US-2014142052-A1
优先权日:2012-05-17
标 题:Phosphorylated polyols, pyrophosphates, and derivatives thereof having biological activity
发明人：LEHN JEAN-MARIE; NICOLAU YVES CLAUDE; POTHUKANURI SRINIVASU; BROCKMAN ADAM; HEY JOHN; YU JEREMY
权利人:NORMOXYS INC; UNIV STRASBOURG
摘要:The present invention provides phosphorylated and pyrophosphate derivatives of polyols, and structural derivatives of these compounds, and provides pharmaceutical compositions comprising the same. The compounds and compositions disclosed herein have various biological activities, including for example, as allosteric effectors of hemoglobin and/or as kinase inhibitors. The present invention further provides methods for therapy in human or mammalian patients, and methods for synthesis of biologically active compounds and their intermediates.
专利号:US-2015353854-A1
优先权日:2014-06-09
标题:Synthesis of fuels and chemicals from sugars
发明人：HENRI JOHN T; ZYGMUNT JAN; ZUBRIN ROBERT
权利人:PIONEER ENERGY INC
摘要:Methods to synthesize useful alcohol and aromatic hydrocarbon products from sorbitol derived from sugars are described. Sorbitol is dehydrated to form furans such as 2-acetylfuran which is hydrogenated to form hexanols, ethyl tetrahydrofuran, etc useful as fuels and chemicals for industry and commerce. Sorbitol may also be heated over a dehydrating catalyst to form aromatic hydrocarbons useful as fuels.
专利号:WO-2012088416-A2
优先权日:2010-12-23
标 题:Chemoenzymatic synthesis of structurally homogeneous ultra-low molecular weight heparins
专利号:US-2013296540-A1
优先权日:2010-12-23
标 题 :Chemoenzymatic synthesis of structurally homogeneous ultra-low molecular weight heparins
专利号:US-4968790-A
优先权日:1988-08-12
标题:Antidiabetic phosphates
发明人：DEVRIES VERN G; CLAUS THOMAS H; FLOYD JR MIDDLETON B; AYRAL-KALOUSTIAN SEMIRAMIS
权利人:AMERICAN CYANAMID CO
摘要:Phosphates are disclosed which stimulate the enzyme fructose-1,6-bisphosphatase and inhibit the enzyme 6-phosphofructo-1-kinase, thereby lowering glucose levels in mammals. These phosphates may thus be used to treat hyperglycemia and/or diabetes. Processes for the synthesis of the phosphates are also disclosed.
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品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
参考标题:Total Synthesis Of An Antitumor Agent, Mucocin, Based On The "Chiron Approach"作者:Shunya Takahashi,Tadashi Nakata |发布日期:2002.8.1
摘要:Aldehyde 4 In The Presence Of Cecl(3). Synthesis Of The Lactone 3 Relied On A Novel Approach By Taking Advantage Of A Radical Cyclization Of Acyclic Selenocarbonate 6. The Three Building Blocks 4, 5A, And 6 Were Prepared Stereoselectivly From D-Galactose (7), 2,5-Anhydro-D-Mannitol (8), And L-Rhamnose (9), Respectively. A New And Efficient Method For Desymmetrization Of The C(2)-Symmetrical Compound 8 Is
合成参考文献
参考文献:10.1002/(sici)1099-1492(199905)12:3<145::aid-nbm559>3.0.co;2-1|10.1002/(sici)1099-1492(199905)12:3<145::aid-nbm559>3.3.co;2-t
摘要:Bruynseels K, Bergans N, Gillis N, van Dorpen F, Van Hecke P, Stalmans W, Vanstapel F. On the inhibition of hepatic glycogenolysis by fructose. A 31P-NMR study in perfused rat liver using the fructose analogue 2,5-anhydro-D-mannitol. NMR Biomed. 1999 May;12(3):145–56. doi: 10.1002/(sici)1099-1492(199905)12:3<145::aid-nbm559>3.0.co;2-1.
参考文献:10.1016/s0005-2736(99)00115-7
摘要:Cermak R, Scharrer E. Effect of 2,5-anhydro-d-mannitol on membrane potential in rat hepatocyte couplets and hepatocyte monolayer cultures. Biochimica et Biophysica Acta (BBA) - Biomembranes. 1999 Sep;1421(1):116–24. doi: 10.1016/s0005-2736(99)00115-7.
参考文献:10.1042/bj20020843
摘要:Yang J, Dowden J, Tatibouët A, Hatanaka Y, Holman GD. Development of high-affinity ligands and photoaffinity labels for the D-fructose transporter GLUT5. Biochem J. 2002 Oct 15;367(Pt 2):533–9.
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