CAS: 40615-08-5; Isoquinolin-1-Ylmethanamine

相似化合物

19382-38-8 1177303-46-6 1436-44-8

上下游产品

1-isoquinolinecarbonitrile 1-isoquinolinecarboxylic acid isoquinoline-1-carboxamide imidazolyl-1-isoquinolinylmethanone (acetate)Cu(bis(1-isoquinolylcarbonyl)amide)

📜咪唑基-1-异喹啉基甲酮置于palladium On Activated Charcoal 氨,氢气,三乙胺,三氟乙酸,三氟乙酸酐体系中,用 甲醇,二氯甲烷 作为反应溶剂,25.0 °C,206.84 Kpa 条件下,反应 2.08H,反应生成 1-异喹啉甲胺
参考文献:Langry,Kevin C.,Organic Preparations And Procedures International,1994,Vol. 26,# 4,P. 429-438
标题:Langry,Kevin C.,Organic Preparations And Procedures International,1994,Vol. 26,# 4,P. 429-438

专利信息

专利号:EP-1836163-B1
优先权日:2004-12-23
标题 :Pyrrolidine derivatives for the treatment of a disease depending on the activity of renin
发明人：BREITENSTEIN WERNER; COTTENS SYLVAIN; EHRHARDT CLAUS; JACOBY EDGAR; LORTHIOIS EDWIGE LILIANE JEANNE; MAIBAUM JUERGEN KLAUS; OSTERMANN NILS; SELLNER HOLGER; SIMIC OLIVER
权利人:NOVARTIS AG
摘要:Novel 3-mono-, 3,4-di- and 3,4,4,-tri-substituted pyrrolidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on inappropriate activity of renin; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on inappropriate activity of renin; the use of a compound of that class in the treatment of a disease that depends on inappropriate activity of renin; pharmaceutical formulations comprising a said substituted pyrrolidine compound, and/or a method of treatment comprising administering a said substituted pyrrolidine compound, a method for the manufacture of said substituted pyrrolidine compounds, and novel intermediates and partial steps for their synthesis are described. The substituted pyrrolidine compounds are especially of the formula I wherein the substituents are as described in the specification.

专利号:US-5514694-A
优先权日:1992-09-21
标题 :Peptidyl ketoamides
发明人：POWERS JAMES C; LI ZHAOZHAO; PATIL GIRISH S; CHU DER-LUN
权利人:GEORGIA TECH RES INST
摘要:A novel class of peptide alpha -ketoamides useful for selectively inhibiting serine proteases, selectively inhibiting cysteine proteases, generally inhibiting all serine proteases, and generally inhibiting all cysteine proteases, having the formula Y-CO-AA2-AA1-CO-NH-X. Processes for the synthesis of peptidyl alpha -ketoamide derivatives.