CAS: 402-05-1; 2-Bromo-5-(Trifluoromethyl)Phenol

上下游产品

CAS号98-17-9 3-三氟甲基苯酚 | CAS号402-07-3 2-溴-5-三氟甲基苯甲醚 | CAS号448-36-2 2-甲氧基-4-(三氟甲基)苯甲酸

间三氟甲基苯酚置于溴体系中,用 二硫化碳,正己烷 作为反应溶剂,以48.8 Gm (53%)的收率获得产物2-溴-5-三氟甲基苯酚
参考文献:Benzofurylpiperazine Serotonin Agonists
标题:Benzofurylpiperazine Serotonin Agonists
摘要:本发明提供了公式i的类胺苯并呋喃化合物:其中r是甲基或乙基,或其药用可接受的酸盐.

专利信息

专利号:US-2010120784-A1
优先权日:2007-04-20
标题 :Novel heteroaromatic compounds as inhibitors of stearoyl-coenzyme a delta-9 desaturase
发明人：LACHANCE NICOLAS; LI CHUN SING; LECLERC JEAN-PHILPPE; RAMTOHUL YEEMAN K
权利人:LACHANCE NICOLAS; LI CHUN SING; LECLERC JEAN-PHILPPE; RAMTOHUL YEEMAN K
摘要:Heteroaromatic compounds of structural formula (I) or a pharmaceutically acceptable salt thereof, wherein W is a substituted heteroaryl, X and Y are each independently a bond, —O—, —S—, —S(O)—, —S(O) 2 —, —NR 6 —, —C(O)—, —C(CH 3 )(OH)— or —C(CH 3 )â•?CH—, u (I) is an integer from 1 to 4, and Ar is an optionally substituted phenyl or naphtyl, are inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD) The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis, obesity, Type 2 diabetes, insulin resistance, hyperglycemia, Metabolic Syndrome, neurological disease, cancer, and liver steatosis