CAS: 34301-54-7; Adamantane-1-Thiol

该化合物是一种含有硫的长烷衍生物,其特点是结构僵硬,类似笼状,该化合物由于其坚固的骨干,具有高度的热和化学稳定性,因此适合需要强大的分子框架的应用.Thiol功能组对金属表面具有很强的约束力,便于在自组单层(SAMs)和表面改造中使用.它独特的编造和电子特性也使其在有机合成,催化和材料科学中具有价值.该化合物的明确界定结构和再活动在分子设计方面提供了精确的控制,提供了纳米技术,涂层和功能化材料研究方面的优势.

结构式图片

相似化合物

281-23-2 768-94-5 51849-10-6

欧盟法规

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上下游产品

1-adamantyl 2-naphthylmethyl sulfide 1-iodoadamantane 1-(4-Chloro-benzyldisulfanyl)-adamantane 1-(2,6-Dichloro-benzyldisulfanyl)-adamantane 1-adamantyl 2,4-dinitrophenyl disulfide 1-adamantyl (4-nitro)phenyl sulfide

合成工艺路线路线简述

  • 合成目标产物 1-Adamantanethiol 主要起始原料 Adamantane
  • (文献来源)合成步骤主要原料 Adamantane
金刚烷 反应生成1-金刚烷乙醇
参考文献:一氯化硫的自由基取代反应.硫醇的有限合成
标题:一氯化硫的自由基取代反应.硫醇的有限合成
摘要:一氯化硫与一系列饱和脂肪烃的光解产生烷基氯化物,二硫化物和多硫化物,氯化氢和元素硫.导致产生烷基氯和二硫化物和多硫化物的自由基取代反应显示通过氯原子提取反应进行.主要产物二硫化物和多硫化物可以通过氢化铝锂还原成相应的硫醇进行定量转化.该反应描述了合成各种烷基硫醇的简单自由基途径.
Doi:10.1139/v73-502

专利信息


专利号:US-9908846-B2
优先权日:2014-02-21
标题:Composition, synthesis, and use of new arylsulfonyl isonitriles
发明人:FLEMING FRASER FERGUSSON; LUJAN MONTELONGO JESUS ARMANDO
权利人:DUQUESNE UNIV OF THE HOLY GHOST; UNIV HOLY GHOST DUQUESNE
摘要:This invention relates to novel isonitriles, including arylsulfonyl isonitriles, and methods for their synthesis. The isonitriles include a conjugated ring system. The structure is designed with the flexibility to have multiple substitution patterns. The isonitriles may be used in applications including, but not limited to, pharmaceutical compositions.

专利号:US-2003203915-A1
优先权日:2002-04-05
标题 :Nitric oxide donors, compositions and methods of use related applications
发明人:FANG XINQIN; GARVEY DAVID S; GASTON RICKY D; LIN CHIA-EN; RANATUNGA RAMANI R; RICHARDSON STEWART K; WANG TIANSHENG; WANG WEIHENG; WEY SHIOW-JYI
权利人:FANG XINQIN; GARVEY DAVID S; GASTON RICKY D; LIN CHIA-EN; RANATUNGA RAMANI R; RICHARDSON STEWART K; WANG TIANSHENG; WANG WEIHENG; WEY SHIOW-JYI
摘要:The invention describes novel nitric oxide donors and novel compositions comprising at least one nitric oxide donor. The invention also provides novel compositions comprising at least one nitric oxide donor, and, optionally, at least one therapeutic agent. The compounds and compositions of the invention can also be bound to a matrix. The invention also provides methods for treating cardiovascular diseases, for the inhibition of platelet aggregation and platelet adhesion caused by the exposure of blood to a medical device, for treating pathological conditions resulting from abnormal cell proliferation; transplantation rejections, autoimmune, inflammatory, proliferative, hyperproliferative, vascular diseases; for reducing scar tissue or for inhibiting wound contraction, particularly the prophylactic and/or therapeutic treatment of restenosis by administering the nitric oxide donor optionally in combination with at least one therapeutic agent. The invention also provides methods for treating inflammation, pain, fever, gastrointestinal disorders, respiratory disorders and sexual dysfunctions. The nitric oxide donors donate, transfer or release nitric oxide, and/or elevate endogenous levels of endothelium-derived relaxing factor, and/or stimulate endogenous synthesis of nitric oxide and/or are substrates for nitric oxide synthase and are capable of releasing nitric oxide or indirectly delivering or transferring nitric oxide to targeted sites under physiological conditions. The therapeutic agent can optionally be substituted with at least one NO and/or NO 2 group (i.e., nitrosylated and/or nitrosated). The invention also provides novel compositions and kits comprising at least one nitric oxide donor and/or at least one therapeutic agent.

专利号:US-2008125354-A1
优先权日:2005-11-21
标题 :Selective inhibition of matrix metalloproteinases
发明人:FIELDS GREGG B; HAMMER ROBERT
权利人:UNIV FLORIDA ATLANTIC; UNIV LOUISIANA STATE
摘要:Synthetic triple-helical peptides (THPs) are used for the design and synthesis of triple-helical transition state analog inhibitors. These inhibitors feature a phosphonate ester or phosphinic moiety in place of the scissle bond. These groups inhibit MMPs, and methods been developed for their convenient incorporation within a peptide sequence by solid-phase methods.

专利号:US-8507660-B2
优先权日:2009-03-27
标题 :Alpha-selective sialyl phosphate donors for preparation of sialosides and sialoside arrays for influenza virus detection
发明人:WONG CHI-HUEY; CHENG TING-JEN RACHEL; WU CHUNG-YI
权利人:WONG CHI-HUEY; CHENG TING-JEN RACHEL; WU CHUNG-YI; ACADEMIA SINICA
摘要:A novel N-acetyl-5-N,4-O-carbonyl-protected dibutyl sialyl phosphate donor for sialylation of both primary and sterically hindered secondary acceptors to prepare sialosides with high yield and α-selectivity is disclosed. Methods for making disaccharide building blocks comprising α(2→3), α(2→6), α(2→8), α(2→8)/α(2→9) alternate, and α(2→9) sialosides are provided. methods for one-pot synthesis of complex sialosides are disclosed. Libraries of sialosides and methods for using the libraries for detection and receptor binding analysis of surface glycoproteins or pathogens and cancer cells are disclosed. Methods for distinguishing between hemagglutinin (HA) from various strains of influenza are provided.

专利号:US-2015328616-A1
优先权日:2014-05-13
标题:Surface mediated synthesis of polynucleotides, polypeptides and polysaccharides and related materials, methods and systems
发明人:GETHERS MATTHEW; GODDARD III WILLIAM A; WEISS PAUL S; RANDALL JOHN
权利人:CALIFORNIA INST OF TECHN
摘要:Surface mediated polymer synthesizing methods and related systems and materials are described where monomers are attached to monomer binding regions on a surface and subsequently form chemical bonds with adjacent monomers on the surface to form linear polymers selected from polynucleotide, polypeptides and polysaccharides.

专利号:WO-2023113033-A1
优先权日:2021-12-16
标题 :Gas diffusion electrode
发明人:KONDO SHOICHI; MAEDA SHINICHI; SHIGA NORIHITO
权利人:NISSAN CHEMICAL CORP
摘要:[Problem] The present invention addresses the problem of increasing the rate of reaction by controlling ammonium ions, which are generated by ammonia as the objective of the electrolytic synthesis of ammonia and protons that are supplied to the cathode, by means of the cathode and the cathode catalyst layer. [Solution] The present invention provides a gas diffusion electrode which is integrated with a catalyst layer that uses a material selected from the group consisting of cathode catalyst layer materials. Examples of the cathode catalyst layer materials include a fired body and an ionic liquid.
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主要参考文献

[参考文献]: David Crich, Et Al. Alpha-Selective Sialylations At -78 Degrees C In Nitrile Solvents With A 1-Adamantanyl Thiosialoside. J Org Chem. 2007 Sep 28;72(20):7794-7.
[参考文献]: Dennis B Pacardo, Et Al. A Dual Wavelength-Activatable Gold Nanorod Complex For Synergistic Cancer Treatment. Nanoscale. 2015 Jul 28;7(28):12096-103.
[参考文献]: Matthew L Gethers, Et Al. Holey Graphene As A Weed Barrier For Molecules. Acs Nano. 2015 Nov 24;9(11):10909-15.

合成参考文献


参考文献:10.1155/2011/254095
摘要:Shi L, Fleming CJ, Riechers SL, Yin N, Luo J, Lam KS, Liu G. High-Resolution Imaging of Dendrimers Used in Drug Delivery via Scanning Probe Microscopy. Journal of Drug Delivery. 2011 Jun 13;2011():1–12. doi: 10.1155/2011/254095.
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