CAS: 255837-19-5; Di-Tert-Butyl(2'-Methyl-[1,1'-Biphenyl]-2-yl)Phosphine

上下游产品

di(tert-butyl)chlorophosphine 2-bromo-2'-methylbiphenyl 2-bromo-1-chlorobenzene 2-methylphenyl bromide (2-di-t-butylphosphino-2'-methylbiphenyl-3-yl)(η4-1,5-cyclo°Ctadiene)iridium(I) di-μ-chlorido-[(η4-1,5-cyclo°Ctadiene)iridium(I)][(2-di-t-butylphosphino-2'-methylbiphenyl)silver(I)]

邻碘溴苯置于bis-Triphenylphosphine-Palladium(II) Chloride,正丁基锂,Potassium Carbonate体系中,用 乙二醇二甲醚,乙醚,正己烷,水 用作溶剂,化学反应 8.0H,反应生成2-二-叔丁基磷-2'-甲基联苯
参考文献:Palladium-Catalyzed R2(O)P Directed C(Sp2)-h Acetoxylation
标题:Palladium-Catalyzed R2(O)P Directed C(Sp2)-h Acetoxylation
摘要:描述了一种新颖高效的钯催化的c-H乙酰化方法.该方法使用r2(O)P作为导向基团,合成各种取代的2'-磷酸酯联苯-2-Oac化合物.
Doi:10.1039/c4Cc01238K

专利信息

专利号:WO-2025119975-A1
优先权日:2023-12-04
标 题:A method for synthesis of harmine
发明人：HETT ROBERT; GRAB HANUSCH; LAGOUTTE ROMAN
权利人:RECONNECT LABS AG
摘要:The invention relates to a method of synthesis of a compound of formula (I), harmine, according to the method comprising a step of transforming the compound of formula (II), into the compound of formula (I). The invention further relates to a compound of formula (II), which is an intermediate in synthesis of harmine according to the present invention.

专利号:US-2024336649-A1
优先权日:2021-06-21
标 题 :Synthesis of covalent protein dimers that can inhibit myc-driven transcription
发明人：LOAS ANDREI; PENTELUTE BRADLEY L; POMPLUN SEBASTIAN; JBARA MUHAMMAD; SCHISSEL CARLY KATHERINE; RODRIQUEZ JACOB JOSHUA LEE; BUCHWALD STEPHEN LEFFLER; BOIJA ANN; KLEIN ISAAC; HAWKEN SUSANA WILSON; LI CHARLES HAN
权利人:MASSACHUSETTS INST TECHNOLOGY; WHITEHEAD INSTITUTE OF BIOMEDICAL RES
摘要:The disclosure relates to covalent protein dimers of MYC, MAX, and Omomyc; pharmaceutical compositions comprising the covalent protein dimers; methods of making the covalent protein dimers; and methods of treating disorders associated with MYC dysregulation (e.g., cancer) with the covalent protein dimers.

专利号:US-8119835-B2
优先权日:2006-12-28
标 题:Method for preparation of 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphtoic acid
发明人：KALVINSH IVARS; CHERNOBROVIJS ALEKSANDRS; TRIBULOVICH VYACHESLAV; LABEISH VLADIMIR
权利人:KALVINSH IVARS; CHERNOBROVIJS ALEKSANDRS; TRIBULOVICH VYACHESLAV; LABEISH VLADIMIR; JSC GRINDEKS
摘要:A method for preparation of 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoic acid is disclosed based on “one potâ€? synthesis approach including a direct synthesis of boronic acid derivative from 2-(1-adamantyl)-4-bromoanisole and cycloboranes with a subsequent Suzuki-Miyaura coupling with 6-halonaphtenoates and basic hydrolysis of the reaction product in ethylene glycol or 1,2-propanediol.

专利号:US-11718584-B2
优先权日:2019-02-22
标题 :Process for the synthesis anthranilic diamide compounds and intermediates thereof
发明人：KARRI PHANEENDRASAI; PABBA JAGADISH; SHINDE BHARAT UTTAMRAO; KALWAGHE AMOL DNYANESHWAR; MADHAVRAO KAMBLE MARUTI; KLAUSENER ALEXANDER G M; PANMAND DEEPAK SHANKAR
权利人:PI INDUSTRIES LTD
摘要:The present invention disclosed a process for the synthesis of anthranilic diamide compound of formula (I), n n n n n n n n n n wherein, R 1 , R 2 , R 3a , R 3b , R 3c , R 4 , R 5 , R 6 and Z are as defined in the detailed description. The process comprising the step of obtaining a mono- or dicyano substituted aniline compound of formula (IV) which is then converted to an anthranilic acid compound of formula (V) or an anthranilic amide compound of formula (Va). Further, the compound of formula (VI) can be optionally synthesized from compound of formula (IV or V or Va)

专利号:US-2023150994-A1
优先权日:2020-04-07
标 题:Methods for synthesis of chk1 inhibitors
发明人：SCHWAEBE MICHAEL; ROSNER THORSTEN; ZHAO DALIAN; MILLER ROSS; DULINA RICH; HUMORA MICHAEL; GOTTSCHLING STEPHEN E
权利人:SIERRA ONCOLOGY INC
摘要:The present technology relates to processes, compounds, compositions, and methods useful for coupling reactions. Also, the present disclosure provides for novel intermediates, compositions of matter, and processes relating to the Chk1 inhibitor, SRA737.

专利号:US-10457640-B2
优先权日:2016-10-19
标 题:Synthesis of inhibitors of EZH2
发明人：VASWANI RISHI G; HEWITT MICHAEL CHARLES
权利人:CONSTELLATION PHARMACEUTICALS INC
摘要:Provided herein are synthetic methods for the preparation of EZH2 inhibitors.