CAS: 22148-77-2; 1-Methyl-3-Phenylpropylamine

该化合物是一种具有制药合成和有机化学潜在用途的手性地雷化合物,其结构以苯丙基基柱体为特征,在矿体组中采用甲基替代,使其成为制造生物活性分子(包括CNS活性化合物)的多用途中间体.该化合物的立体化学可专门设计成对应选择性合成,加强其在非对称催化和药物开发中的效用.在标准条件下的稳定性和与普通有机试剂的兼容性进一步有助于其适合实验室和工业规模的工艺.该矿物质功能允许进一步衍生,能够合成更复杂的结构.建议进行适当的处理和储存,因为其具有再活动性.

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    海关参考信息

    专利信息


    专利号:WO-0140193-A1
    优先权日:1999-12-03
    标题:Method for the synthesis of pyrazolines
    发明人:BOLDI ARMEN M
    权利人:CHEMRX ADVANCED TECHNOLOGIES I; BOLDI ARMEN M
    摘要:The present invention provides a method for the synthesis of compounds of Formula (I). Also claimed are novel intermediates and their methods of synthesis.

    专利号:US-2002103381-A1
    优先权日:2000-11-30
    标 题 :Method for the synthesis of pyrazolines
    发明人:BOLDI ARMEN M
    摘要:The present invention provides a method for the synthesis of compounds of Formula I: n n n Also claimed are novel intermediates and their methods of synthesis.

    专利号:US-6133018-A
    优先权日:1997-06-02
    标 题 :Enzymatic synthesis of chiral amines using -2-amino propane as amine donor
    发明人:WU WEI; BHATIA MOHIT B; LEWIS CRAIG M; LANG WEI; WANG ALICE L; MATCHAM GEORGE W
    权利人:CELGRO
    摘要:2-Aminopropane is used as the amine donor in the stereoselective synthesis of a chiral amine from a ketone with a transaminase. In a typical embodiment, (S)-1-methoxy-2-aminopropane is prepared by bringing methoxyacetone into contact with a transaminase in the presence of 2-aminopropane as an amine donor until a substantial amount of methoxyacetone is converted to (S)-1-methoxy-2-aminopropane and 2-aminopropane is converted to acetone. In a second embodiment, L-alanine is prepared by bringing pyruvic acid into contact with a transaminase in the presence of 2-aminopropane as an amine donor.

    专利号:EP-1075534-B8
    优先权日:1998-03-11
    标 题 :Improvements in the enzymatic synthesis of chiral amines
    发明人:WU WEI; BHATIA MOHIT B; LEWIS CRAIG M; LANG WEI; WANG ALICE; MATCHAM GEORGE W
    权利人:CELGRO
    摘要:2-Aminopropane is used as the amine donor in the stereoselective synthesis of a chiral amine from a ketone with a transaminase. In a typical embodiment, (S)-1-methoxy-2-aminopropane is prepared by bringing methoxyacetone into contact with a transaminase in the presence of 2-aminopropane as an amine donor until a substantial amount of methoxyacetone is converted to (S)-1-methoxy-2-aminopropane and 2-aminopropane is converted to acetone. In a second embodiment, L-alanine is prepared by bringing pyruvic acid into contact with a transaminase in the presence of 2-aminopropane as an amine donor.

    专利号:US-6472228-B2
    优先权日:2000-12-04
    标题:Composition and methods for synthesis of novel tracers for detecting amphetamine and methamphetamine in samples
    发明人:WANG GUOHONG; FOLEY THOMAS
    权利人:LIFEPOINT INC
    摘要:This invention relates to novel tracers and their synthesis and use in an immunoassay for the detection of controlled drugs such as amphetamine (APM), methamphetamine (MAPM) and their derivatives, in a biological or aqueous sample. In particular, this invention provides methods for synthesizing novel tracers in which a non-controlled substance is both the starting material in tracer synthesis and the binding site on the resulting novel tracer for the antibody, thereby eliminating the necessity of using controlled substances as starting materials. In addition, the novel tracers of the present invention can be used as an analyte analog in an immunoassay, such as a continuous flow displacement immunoassay. It was unexpectedly discovered that the novel tracers of the present invention substantially improve the performance of the continuous flow displacement immunoassay as compared with conventionally designed tracers.

    专利号:US-5965719-A
    优先权日:1996-11-15
    标 题:Combinatorial synthesis of carbohydrate libraries
    发明人:HINDSGAUL OLE
    权利人:SUNSORB BIOTECH INC
    摘要:Disclosed are methods for synthesizing very large collections of diverse thiosaccharide derivatives optionally attached to a solid support. Also disclosed are libraries of diverse thiosaccharide derivatives.

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    合成参考文献


    摘要:Scammells, P. J., Science of Synthesis Knowledge Updates, (2013) 2, 445.
    摘要:Rodríguez-Mata, M.; Gotor-Fernández, V., Science of Synthesis: Biocatalysis in Organic Synthesis, (2015) 1, 208.
    摘要:Schmidberger, J. W.; Hepworth, L. J.; Green, A. P.; Flitsch, S. L., Science of Synthesis: Biocatalysis in Organic Synthesis, (2015) 1, 353.
    摘要:Simon, R. C.; Busto, E.; Fischereder, E.-M.; Fuchs, C. S.; Pressnitz, D.; Richter, N.; Kroutil, W., Science of Synthesis: Biocatalysis in Organic Synthesis, (2015) 2, 414.
    摘要:Simon, R. C.; Busto, E.; Fischereder, E.-M.; Fuchs, C. S.; Pressnitz, D.; Richter, N.; Kroutil, W., Science of Synthesis: Biocatalysis in Organic Synthesis, (2015) 2, 398.
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