4-氯丁醇醋酸酯置于sodium Sulfite,盐酸体系中,用 水,甲醇 用作溶剂,110.0 °C,2.67 Kpa 条件下,反应 4.0H,以92%的收率获得1,4-丁磺酸内酯 参考文献: A Process For Preparation Of Sultones[fr] Procédé De Préparation De Sultones 标题: A Process For Preparation Of Sultones[fr] Procédé De Préparation De Sultones 摘要:本发明的主要目的是提供一种经济实用的制备式(I)磺酮的方法,其中n为1-3.1,3-丙烷磺酮和1,4-丁烷磺酮等磺酮广泛用于电镀中间体,制药中间体,光敏材料,锂电池和其他家庭化学品.
专利号:US-11964965-B2 优先权日:2020-05-08 标题 :Methods of manufacture and synthesis of fluorescent dye compounds and uses thereof 发明人:KULARATNE SUMITH A; GAGARE PRAVIN 权利人:ON TARGET LABORATORIES LLC 摘要:The present disclosure relates to synthesizing and utilizing fluorescent dye compounds or pharmaceutically acceptable salts thereof. Conjugation of amino acid groups to the fluorescent dyes increase specificity and detection of the compound. Methods of manufacture and synthesis of the compounds for use thereof in diagnostic imaging are contemplated.
专利号:US-2025177964-A1 优先权日:2023-11-30 标题 :Synthesis procedure of homopolymers and copolymers based on vinyl ionic liquids, n-vinylpyrrolidone or vinylpyridine and the methodology for their application as catalysts in alkylation reactions of isoparaffins and olefins 发明人:PAZ ARACELI VEGA; DOMÃ?NGUEZ MERCEDES BAZALDUA; LUCERO DIEGO JAVIER GUZMÃ?N; CORTEZ JOSÉ GONZALO HERNÃ?NDEZ; ROBLES NOHEMÃ? ORNELAS; PANTOJA JAVIER GUZMÃ?N; PALOU RAFAEL MARTÃ?NEZ 权利人:MEXICANO INST PETROL 摘要:The present disclosure relates to a procedure for the synthesis of polymers (homo and copolymers) of the poly (ionic liquid) (PIL) type. The homopolymers are derived from polyvinylimidazolium, polyvinylpyrrolidone or polyvinylpyridine and the copolymers from monomers of vinyl ionic liquids (ILs) are derived from imidazole and N-vinylpyrrolidone. The structural modification of these homopolymers and copolymers occurs by using strong inorganic acids such as sulfuric, chlorosulfonic and bromosulfonic, among others, and halide metallic salts such as AlCl3, FeCl3, CuCl, ZnCl2, and SnCl2. Also, these PILs are employed as catalysts in alkylation reactions between isoparaffins and olefins for producing alkylate gasoline.
专利号:US-2009318627-A1 优先权日:2006-02-07 标题:Solid phase synthesis of acridinium derivatives 发明人:NATRAJAN ANAND; SHARPE DAVID; COSTELLO JIM; JIANG QINGPING 权利人:SIEMENS HEALTHCARE DIAGNOSTICS 摘要:Acridinium-functionalized solid-phase supports and methods for making acridinium-functionalized solid-phase supports are disclosed. The acridinium-functionalized solid-phase supports comprise a solid phase support linked to a chemiluminescent substituted acridinium compound through a linker group covalently attached to the nitrogen atom of the acridinium nucleus and the solid phase support as exemplified in FIG. 1.
专利号:US-9296942-B2 优先权日:2010-04-16 标 题:Anionic polyalkoxy group comprising surfactants on basis of guerbet-alcohols, method of manufacture and use in enhanced oil recovery (EOR) applications 发明人:WEERASOORIYA UPALI P; POPE GARY A; BITTNER CHRISTIAN; OETTER GUNTER; TINSLEY JACK F; SPINDLER CHRISTIAN; JURGENSON GABRIELA ALVAREZ; VOGEL SOPHIE 权利人:UNIV TEXAS; BASF SE 摘要:Compositions and methods of synthesis of anionic surfactants by alkoxylation of a Guerbet alcohol (GA) having 12 to 36 carbon atoms using butylene oxide, and optionally propylene oxide and/or ethylene oxide followed by the incorporation of a terminal anionic group are described herein. The GA of the present invention is made by a facile and inexpensive method that involves high temperature base catalyzed dimerization of alcohols with 6 to 18 carbon atoms. The large hydrophobe ether surfactants of the present invention find uses in enhanced oil recovery (EOR) applications where it is used for solubilization and mobilization of oil and for environmental cleanup. Further, the hydrophobe alkoxylated GA without anionic terminal group can be used as an ultra-high molecular weight non-ionic surfactant.
专利号:US-11274164-B2 优先权日:2017-02-07 标 题 :Method for the preparation of sulfobutylether beta cyclodextrin sodium 发明人:PULLAGURLA MANIK REDDY; PITTA BHASKAR REDDY; NAMANA SURESH BABU; NAGARAPU RADHA; RANGISETTY JAGADEESH BABU 权利人:BIOPHORE INDIA PHARMACEUTICALS PVT LTD 摘要:The present invention relates to an improved method for the synthesis of sulfobutylether beta cyclodextrin sodium and to provide an amorphous form of sulfobutylether beta cyclodextrin sodium having a 1,4-butane sultone content less than 0.5 ppm. The present invention further provides sulfobutylether beta cyclodextrin sodium containing less than 35 IU/g of Bacterial endotoxins.
专利号:US-6989401-B2 优先权日:2000-07-19 标题:Sulfonic acid derivatives of hydroxamic acids and their use as medicinal products 发明人:MAEDA KAZUHIRO; SONDA SHUJI; TAKEMOTO TADAHIRO; GOTO TOMOKAZU; KOBAYASHI FUJIO; KAJII MASAHIKO; KOMORITA NARUYASU; HIRAYAMA FUMIHIRO 权利人:MITSUBISHI PHARMA CORP 摘要:The present invention relates to a novel sulfonic acid derivative of hydroxamic acid or a pharmacologically acceptable salt thereof. More particularly, the present invention relates to a sulfonic acid derivative of hydroxamic acid or a pharmacologically acceptable salt thereof, which is useful as an inhibitor of lipopolysaccharides (LPS). In addition, the present invention relates to a novel intermediate compound useful for the synthesis of this sulfonic acid derivative of hydroxamic acid.
[参考文献]: Ana-Maria Rosu, Et Al. Synthesis Of Alkylated Potato Starch Derivatives And Their Potential In The Aqueous Solubilization Of Benzo[参考文献]: N Rogmann, Et Al. Determination Of The Substituent Distribution In O-Sulfonylbutyl-(1-->4)-Glucans. Carbohydr Res. 2000 Jul 24;327(3):275-85.
合成参考文献
摘要:Dekeukeleire, S.; D'hooghe, M.; De Kimpe, N., Science of Synthesis Knowledge Updates, (2011) 3, 158. 摘要:U.S. Department of Health and Human Services, Public Health Service, Center for Disease Control, National Institute for Occupational Safety Health. Registry of Toxic Effects of Chemical Substances (RTECS). National Library of Medicine's current MEDLARS file., p. 84/8406 摘要:Kleemann A., Kutscher B., Reichert D., Bossart M., Pharmaceutical Substances, Thieme [Online], Stuttgart, (2025). 参考文献:10.1385/1-59259-798-x:039 摘要:Sowell J, Salon J, Strekowski L, Patonay G. Covalent and noncovalent labeling schemes for near-infrared dyes in capillary electrophoresis protein applications. Methods Mol Biol. 2004;276():39–75. doi: 10.1385/1-59259-798-x:039.