CAS: 154237-70-4; 4-Bromo-3-Cyanopyridine

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CAS号92905-81-2 3-phenyl-2H-2,7...

3-氰基-4-甲氧基吡啶置于三溴氧磷体系中,用 乙腈 用作溶剂,以61 %的收率获得4-溴-3-氰基吡啶
参考文献:一种4-溴-3-氰基吡啶的合成方法
标题:一种4-溴-3-氰基吡啶的合成方法
摘要:本发明公开了一种4‑溴‑3‑氰基吡啶的合成方法,它包括以下步骤:(1)在碱性条件下,通过三氯氧磷氧化羟基,制备中间产物2‑氯‑3‑氰基‑4‑甲氧基吡啶;(2)将步骤(1)中得到的产物置于乙醇中,加入钯碳,并向其中缓慢通入氢气,制备中间产物3‑氰基‑4‑甲氧基吡啶;(3)向步骤(2)所得产物的乙腈溶液中加入三溴氧磷,制备目标产物4‑溴‑3‑氰基吡啶.本发明采用的合成方法具有原料易得,反应条件温和,催化剂可回收套用,无重金属污染和产物后处理简单等优势,适用于工业化生产.

专利信息

专利号:US-2025129021-A1
优先权日:2023-09-19
标 题:Small molecule protein synthesis modulators
发明人：GYGI DAVID; BAHMANYAR SOGOLE SAMI; HAMANN LAWRENCE
权利人:INTERDICT BIO INC
摘要:The present disclosure provides compounds of the formulae herein (e.g., Formula (I), Formula (V)), and pharmaceutically acceptable salts thereof, which are useful for modulating protein synthesis (e.g., modulating synthesis of BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D). The present disclosure also provides pharmaceutical compositions and kits comprising the compounds, or pharmaceutically acceptable salts thereof, and methods of treating or preventing diseases or disorders (e.g., diseases or disorders associated with BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D) by administering to a subject in need thereof the compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof.

专利号:CN-117551029-A
优先权日:2023-11-22
标 题:Synthesis method of 4-bromo-3-cyanopyridine