CAS: 1455-77-2; 3,5-Diamino-1,2,4-Triazole

氰胺置于copper Hydroxide,氯化铵,Sodium Sulfide体系中,用 水 用作溶剂,化学反应 3.5H,以88%的收率获得3,5-二氨基-1,2,4-三氮唑
参考文献:一种3,5-二氨基-1,2,4-三氮唑水热合成方法
标题:一种3,5-二氨基-1,2,4-三氮唑水热合成方法
摘要:本发明提供一种3,5‑二氨基‑1,2,4‑三氮唑水热合成方法,包括:以氰基取代衍生物,铵盐,氢氧化铜以及水为原料,在高压条件下,水热合成3,5‑二氨基‑1,2,4‑三氮唑.本发明以单氰胺,铵盐,氢氧化铜为原料,采用高压反应装置,利用铵盐在氢氧化铜作用下分解出的氨与两分子单氰胺缩合,生成双胍合铜配合物.双胍合铜配合物在硫化物存在的条件下脱去硫化亚铜,缩环得到3,5‑二氨基三氮唑.利用高压反应釜提高了氨在水体系中的浓度,有利于缩合反应的发生,同时有效降低了单氰胺缩合所需要的时间和温度.利用过量的铵盐存在,可以稳定整体反应体系ph值,避免单氰胺聚合副反应的发生.本发明工艺简单,原料成本低,最终产品纯度高.

专利信息

专利号:US-6881847-B2
优先权日:2001-02-01
标题:Process for the synthesis and recovery of nitramines
发明人：HIGHSMITH THOMAS K; HANKS JAMI M; VELARDE STEPHEN P; BOTTARO JEFFREY
权利人:ALLIANT TECHSYSTEMS INC
摘要:A method is provided for the synthesis of nitramines and the recovery of the nitramines from a clathrate.

专利号:US-2012149888-A1
优先权日:2009-02-22
标 题:Synthesis of ara-2'-o-methyl-nucleosides, corresponding phosphoramidites and oligonucleotides incorporating novel modifications for biological application in therapeuctics, diagnostics, g- tetrad forming oligonucleotides and aptamers
发明人：SRIVASTAVA SURESH C; PANDEY DIVYA; SRIVASTAVA NAVEEN P; SRIVASTAVA ALOK
权利人:SRIVASTAVA SURESH C; PANDEY DIVYA; SRIVASTAVA NAVEEN P; SRIVASTAVA ALOK
摘要:The present invention relates to synthesis, purification and methods to obtain high purity novel 2′-arabino-O-methyl nucleosides and the corresponding phosphoramidites of various arabinonucleoside bases and introduction of such units into defined sequence synthetic DNA and RNA. Various synthetic oligonucleotides, such as HIV integrase inhibitor 14-mer and thrombin binding oligonucleotide, thrombin-1, bearing ara-2′-omethyl modification have been synthesized. It is anticipated the oligonucleotides incorporating these monomers will exhibit biological activities related to antisense approach approach, design of better SiRNA's, diagnostic agents. Similarly, it is anticipated that oligonucleotides incorporating such novel nucleosides will be useful to develop therapeutic candidates designing stable G-quadruplexes and Aptamers for oligonucleotide structure, folding topology, evaluation of biochemical properties and design and develop as therapeutic agents. It is further anticipated that the nucleosides, phosphates and triphosphates of this invention could develop as therapeutic agents.

专利号:US-10737239-B2
优先权日:2015-11-27
标题 :Ultrafast high space-time-yield synthesis of metal-organic frameworks
发明人：BURCKHART JULIA; MARX STEFAN; ARNOLD LENA; HOFMANN CLAUS; Müller Ulrich
权利人:BASF SE
摘要:The invention relates to a process for the preparation of metal-organic frameworks (MOFs) in form of a homogenous powder, and a process wherein the metal-organic framework is molded into shaped bodies.

专利号:US-11472779-B1
优先权日:2022-05-13
标 题 :One-pot synthesis of hydrogen-bonded organic frameworks
发明人：KHAN MOHD YUSUF; KHAN ABUZAR; HELAL AASIF; YAMANI ZAIN H
权利人:UNIV KING FAHD PET & MINERALS
摘要:A hydrogen-bonded organic framework (HOF) and a method of making the HOF. The HOF has at least one amine substituted organic linker and at least one carboxylic acid-based organic linker. The HOF is prepared by dissolving the linkers separately in water and mixing the aqueous solutions, without using any organic solvents, additional catalysts, or any other reagents.

专利号:US-4236014-A
优先权日:1979-11-07
标 题:Production of the ammonium salt of 3,5-dinitro-1,2,4-triazole by solvent extraction
发明人：LEE KIEN Y; OTT DONALD G
权利人:US ENERGY
摘要:The ammonium salt of 3,5-dinitro-1,2,4-triazole has utility as a chemical explosive. In accordance with the present invention, it may readily be produced by solvent extraction using high-molecular weight, water-insoluble amines followed by amination with anhydrous ammonia gas. The aqueous reaction mixture produced in the synthesis of the parent compound, 3,5-dinitro-1,2,4-triazole, is quite suitable--and indeed is preferred--for use as the feed material in the process of the invention.

专利号:US-8399502-B2
优先权日:2008-09-17
标 题 :Analogs of indole-3-carbinol and their use as agents against infection
发明人：JONG LING; JIANG FAMING; LI GAOQUAN; MORTELMANS KRISTIEN
权利人:JONG LING; JIANG FAMING; LI GAOQUAN; MORTELMANS KRISTIEN; STANFORD RES INST INT
摘要:Compounds useful as antibacterial agents are provided. The compounds are analogs of indole-3-carbinol and have a backbone selected from dihydroindolo[2,3-b]carbazole, 2,2′-diindolylmethane, 2′,3-diindolylmethane, and 3,3′-diindolylmethane. The compounds are useful therapeutic and prophylactic treatment of bacterial infections in mammals. Methods of synthesis of the compounds are provided, as are pharmaceutical compositions containing the compounds.