CAS: 1448-87-9; 2-Chloroquinoxaline

相似化合物

2213-63-0 18671-97-1 55687-33-7

上下游产品

CAS号1196-57-2 喹唑酮 | CAS号5227-59-8 2-CHLOROQUINOXA... | CAS号95-54-5 邻苯二胺(OPD) | CAS号51-17-2 苯并咪唑 | CAS号67-66-3 氯仿 | CAS号61645-34-9 2-肼基喹喔啉 | CAS号120569-15-5 benzophenone O-... | CAS号18671-97-1 2,6-二氯喹喔啉 | CAS号20254-76-6 3-氯喹喔啉-2-羧酸 | CAS号2427-71-6 2-羟基-6-氯喹喔啉 | CAS号105702-07-6 2-(2-methylphen... | CAS号59-40-5 磺胺喹噁啉 | CAS号5021-45-4 2-(4-溴苯基)喹喔啉 | CAS号18503-48-5 2-tert-butylqui... | CAS号37052-98-5 Furo[2,3-b]quin... | CAS号95-54-5 邻苯二胺(OPD) | CAS号40598-86-5 2-(thien-2-yl)f... | CAS号29067-85-4 四唑并[1,5-a]喹喔啉-4... | CAS号2712-12-1 Quinoxaline, 2-...

3-Chloroquinoxaline 1-Oxide置于二甲基膦酸钠体系中,用 四氢呋喃 用作溶剂,化学反应 4.0H,以85%的收率获得2-氯喹恶啉
参考文献:2-膦酰基化喹喔啉1,4-二氧化物的首次合成:贝鲁特反应的扩展
标题:2-膦酰基化喹喔啉1,4-二氧化物的首次合成:贝鲁特反应的扩展
摘要:描述了贝鲁特反应的扩展,用于制备2-膦酰化的喹喔啉1,4-二氧化物系列的第一成员.与它们的羧基当量相反,这些新化合物的制备在碱性条件下无法实现,但需要使用粉末分子筛.仅当最初的四氢呋喃悬浮液通过缓慢蒸发ca转化为糊状膜时,才能获得非常好且可重现的收率.初始溶剂体积的90%.
Doi:10.1016/j.Tetlet.2010.07.148

专利信息

专利号:US-3886180-A
优先权日:1973-03-15
标 题:Process for the synthesis of N-hydroxypyrroles
发明人：ABRAMOVITCH RUDOLPH ABRAHAM; CUE JR BERKELEY WENDELL
权利人:ABRAMOVITCH RUDOLPH ABRAHAM; CUE JR BERKELEY WENDELL
摘要:A process is described for the preparation of N-hydroxypyrrole2-carbonitriles, N-hydroxyimidazole-2-carbonitriles, pyrrole-2carbonitriles, and 3-substituted-2, 3-dihydro-2-pyrrolones by thermally decomposing 2-azidoheteroaromatic N-oxides. In the process a 2-azidoheteroaromatic N-oxide is heated in a suitable solvent for a period of time sufficient to bring the reaction to completion. Removal of the solvent by conventional methods gives the desired product. Which product is obtained is determined by the choice of solvents. In non-polar aprotic solvents, Nhydroxypyrrole-2-carbonitriles or N-hydroxyimidazole-2carbonitriles are obtained. In nucleophilic solvents capable of undergoing Michael-type additions pyrrole-2-carbonitriles, imidazole-2-carbonitriles, and 3-substituted-2,3-dihydro-2pyrrolone derivatives are obtained where a solvent molecule comprises the 3-substituent. These compounds are useful as antibaterials, e.g., against E. Coli.

专利号:US-4006160-A
优先权日:1973-03-15
标题:Process for the synthesis of N-hydroxypyrroles, N-hydroxyimidazoles, and derivatives thereof
发明人：ABRAMOVITCH RUDOLPH ABRAHAM; CUE JR BERKELEY WENDELL
权利人:UNIV ALABAMA
摘要:A process is described for the preparation of N-hydroxypyrrole-2-carbonitriles, N-hydroxyimidazole-2-carbonitriles, pyrrole-2-carbonitriles, and 3-substituted-2, 3-dihydro-2-pyrrolones by thermally decomposing 2-azidoheteroaromatic N-oxides. In the process a 2-azidoheteroaromatic N-oxide is heated in a suitable solvent for a period of time sufficient to bring the reaction to completion. Removal of the solvent by conventional methods gives the desired product. Which product is obtained is determined by the choice of solvents. In non-polar aprotic solvents, N-hydroxypyrrole-2-carbonitriles or N-hydroxyimidazole-2-carbonitriles are obtained. In nucleophilic solvents capable of undergoing Michael-type additions pyrrole-2-carbonitriles, imidazole-2-carbonitriles, and 3-substituted-2,3-dihydro-2-pyrrolone derivatives are obtained where a solvent molecule comprises the 3-substituent. These compounds are useful as anti-bacterials, e.g., against E. Coli.

专利号:WO-2024233563-A1
优先权日:2023-05-09
标 题:6,6-fused bicyclic amides and compositions for use as 15-prostaglandin dehydrogenase modulators
发明人：GREENMAN KEVIN LLOYD; WANG HUI-LING; WEIRES NICHOLAS ANTHONY; ALLEN JOHN G; AMEGADZIE ALBERT K; BOURBEAU MATTHEW P; LI KEXUE
权利人:AMGEN INC
摘要:The present disclosure provides novel 15-hydroxy-prostaglandin dehydrogenase inhibitors, pharmaceutical compositions comprising such compounds, and methods of using such compounds and compositions in treating 15-hydroxy-prostaglandin dehydrogenase-mediated disease. Also provided are methods of making such compounds and intermediates thereof. The compounds have a structure of Formula (I): or a pharmaceutically acceptable salt thereof; wherein is Formula (i) or Formula (ii) Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula (I).

专利号:CN-107759604-A
优先权日:2017-10-11
标题 :A kind of method that catalyzes the synthesis of benzimidazoquinoxaline derivatives under microwave radiation

专利号:US-6936600-B2
优先权日:1999-04-01
标题:Sorbitol dehrydrogenase inhibitors
发明人：CHU-MOYER MARGARET Y; MYLARI BANAVARA L; ZEMBROWSKI WILLIAM J
权利人:PFIZER
摘要:This invention is directed to sorbitol dehydrogenase inhibitory compounds of the formula I, n n nwherein R 1 , R 2 and R 3 are as defined in the specification. This invention is also directed to pharmaceutical compositions containing those compounds and methods of treating or preventing diabetic complications, particularly diabetic neuropathy, diabetic nephropathy, diabetic microangiopathy, diabetic macroangiopathy and diabetic cardiomyopathy by administering such compounds to a mammal suffering from diabetes and therefore at risk for developing such complications. This invention is also directed to pharmaceutical compositions comprising a combination of a compound of formula I of this invention with an aldose reductase inhibitor and to methods of treating or preventing diabetic complications therewith. This invention is also directed to pharmaceutical compositions comprising a combination of a compound of formula I of this invention with an NHE-1 inhibitor and to methods of treating cardiomyopathy and other heart-related problems therewith. This invention is also directed to certain intermediates used in the synthesis of the compounds of formula I and to processes for preparing those intermediates.

专利号:CN-114262345-B
优先权日:2022-01-24
标题 :Synthesis method of a new type of chiral compound with phosphine center