CAS: 14099-81-1; 1,2,3,4-Tetrahydroisoquinolinehydrochloride

该化合物是一种化学化合物,其特点是由饱和等离子体框架组成的双环结构,通常作为盐酸盐,提高其水溶性,使其适合医药化学和药理学的各种应用;该化合物展示了一系列生物活动,包括潜在的...

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CAS号1071-71-2 6-氯-6-氧代己酸乙酯(硫辛酸杂质) | CAS号91-21-4 1,2,3,4-四氢异喹啉 | CAS号7647-01-0 盐酸 | CAS号14429-05-1 3.4-dihydro iso... | CAS号142266-67-9 benzyl 3,4-dihy... | CAS号22990-19-8 1-苯基-1,2,3,4-四氢异喹啉 | CAS号1612-65-3 2-甲基-1,2,3,4-四氢异喹啉 | CAS号4836-98-0 Isoquinoline, 2...

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    📜四氢异喹啉置于盐酸体系中,用 乙醚 用作溶剂,化学反应生成1,2,3,4-四氢异喹啉 盐酸盐
    参考文献:自组装有机-无机杂化物:双(1,2,3,4-四氢异喹啉-2-鎓)六卤代锡酸盐(Iv)的合成,结构,三阶非线性光学性质和hirshfeld表面分析
    标题:自组装有机-无机杂化物:双(1,2,3,4-四氢异喹啉-2-鎓)六卤代锡酸盐(Iv)的合成,结构,三阶非线性光学性质和hirshfeld表面分析
    摘要:两种有机-无机杂化物,即双(1,2,3,4-四氢异喹啉-2-鎓)六氯锡酸盐(iv)(1)和双(1,2,3,4-四氢异喹啉-2-鎓)六溴锡酸盐(四) ( 2) 合成并通过单晶 X 射线衍射分析证实.通过漫反射和光致发光光谱研究来研究化合物的光学性质.化合物的热行为是通过关于温度的热重 (Tg) 和差热分析 (Dta) 确定的.Z-扫描研究揭示了化合物显示的显着的三阶非线性光学响应.通过扫描电子显微镜 (Sem) 和能量色散 X 射线光谱 (Eds) 分析研究了化合物的表面形貌和元素组成.键价和 (Bvs) 计算证实锡的正式氧化态为 +4.检查 Snx62− (X=cl,Br) 产生的值非常接近阴离子的完美八面体几何形状.通过 Hirshfeld 分析和指纹图研究了分子间相互作用及其在晶体堆积中的数量贡献.
    Doi:10.1016/j.Molstruc.2021.131092

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    专利号:US-9446995-B2
    优先权日:2012-05-21
    标 题:Synthesis of therapeutic and diagnostic drugs centered on regioselective and stereoselective ring opening of aziridinium ions
    发明人:CHONG HYUN-SOON
    权利人:CHONG HYUN-SOON; ILLINOIS INST OF TECH
    摘要:Stereoselective and regioselective synthesis of compounds via nucleophilic ring opening reactions of aziridinium ions for use in stereoselective and regioselective synthesis of therapeutic and diagnostic compounds.

    专利号:US-10189803-B2
    优先权日:2008-02-22
    标题 :Synthesis of therapeutic and diagnostic drugs centered on regioselective and stereoselective ring opening of aziridinium ions
    发明人:CHONG HYUN-SOON
    权利人:CHONG HYUN SOON; ILLINOIS INSTITUTE OF TECH
    摘要:Stereoselective and regioselective synthesis of compounds via nucleophilic ring opening reactions of aziridinium ions for use in stereoselective and regioselective synthesis of therapeutic and diagnostic compounds.

    专利号:US-8822702-B2
    优先权日:2002-12-20
    标 题 :Synthesis of amines and intermediates for the synthesis thereof
    发明人:BERENS ULRICH; DOSENBACH OLIVER; SPRENGER DANIEL
    权利人:BERENS ULRICH; DOSENBACH OLIVER; SPRENGER DANIEL; BASF SE
    摘要:The invention relates in a first embodiment to a method for the manufacture of esters of the formula I, n nor especially of amides of the formula II,n n nwherein the symbols have the meanings given in the specification, as well as other intermediates and compounds useful in the synthesis of tryptamines and other substances mentioned in the title. The synthesis methods and intermediates are useful in the synthesis of pharmaceuticals.

    专利号:US-11548898-B2
    优先权日:2017-07-06
    标题 :Synthesis of halichondrins
    发明人:KISHI YOSHITO; AI YANRAN; YE NING; WANG QIAOYI; YAHATA KENZO; ISO Kentaro; NAINI SANTHOSH REDDY; YAMASHITA SHUJI; LEE JIHOON; OHASHI ISAO; FUKUYAMA TAKASHI
    权利人:HARVARD COLLEGE; EISAI R&D MAN CO LTD
    摘要:The present invention provides methods for the synthesis of ketones involving a Ni/Zr-mediated coupling reaction. The Ni/Zr-mediated ketolization reactions can be used in the synthesis of halichondrins (e.g., halichondrin A, B, C; homohalichondrin A, B, C; norhalichondrin A, B, C), and analogs thereof. Therefore, the present invention also provides synthetic methods useful for the synthesis of halichondrins, and analogs thereof. Also provided herein are compounds (i.e., intermediates) useful in the synthesis of halichondrins, and analogs thereof. In particular, the present invention provides methods and compounds useful in the synthesis of compound of Formula (H3-A).

    专利号:US-4902817-A
    优先权日:1987-09-17
    标 题 :Process for the synthesis of alpha n alkylated amino acids and esters thereof, application to the synthesis of carboxyalkyl dipeptides
    发明人:VINCENT MICHEL; BALIARDA JEAN; MARCHAND BERNARD; REMOND GEORGES
    权利人:ADIR
    摘要:Stereoselective process for the industrial synthesis of compounds of formula (I): ##STR1## where R 1 is linear or branched lower alkyl with 1 to 6 carbon atoms, n R 2 is a linear or branched lower alkyl with 1 to 4 carbon atoms, n employing inexpensive starting materials and obtaining optimum yields. n Application to the synthesis of carboxyalkyl dipeptides.

    专利号:US-7825244-B2
    优先权日:2005-06-10
    标题:Intermediates useful in the synthesis of alkylquinoline and alkylquinazoline kinase modulators, and related methods of synthesis
    发明人:BAINDUR NAND; GAUL MICHAEL DAVID; KREUTTER KEVIN DOUGLAS; XU GUOZHANG
    权利人:JANSSEN PHARMACEUTICA NV
    摘要:The invention is directed to alkylquinoline and alkylquinazoline compounds of Formula C: n nwherein R 1 , R 2 , R 99 , and X are as defined herein, the use of such compounds in the synthesis of protein tyrosine kinase inhibitors, particularly inhibitors of FLT3 and/or c-kit and/or TrkB.

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    合成参考文献


    摘要:Journal of Pharmacology and Experimental Therapeutics., 62(165), 1938
    摘要:Journal of Medicinal Chemistry., 18(1194), 1975
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