CAS: 140373-77-9; Tert-Butyl 4-Amino-2-Fluorobenzoate

相似化合物

446-31-1 157665-46-8 1449588-17-3

上下游产品

CAS号157665-46-8 2-氟-4-硝基苯甲酸叔丁酯 | CAS号7439-89-6 铁粉 | CAS号403-24-7 2-氟-4-硝基苯甲酸 | CAS号403-23-6 2-氟-4-硝基苯甲酰氯 | CAS号1427-07-2 2-氟-4-硝基甲苯 | CAS号324788-98-9 4-苄氧基羰基氨基-2-氟-苯甲酸叔丁酯

📜2-氟-4-硝基甲苯置于chromium(Vi) Oxide,氯化亚砜,铁粉,氯化铵,溶剂黄146体系中,用 四氢呋喃,二氯甲烷 用作溶剂,化学反应生成叔-丁基 4-氨基-2-氟苯甲酸
参考文献:Novel Oxazolidinone-quinolone Hybrid Antimicrobials
标题:Novel Oxazolidinone-quinolone Hybrid Antimicrobials
摘要:Antimicrobial Compounds Incorporating Oxazolidinone And Quinolone Pharmacophore Substructures Have Been Synthesized And Evaluated. Representative Analogues 2,5,And 6 Display An Improved Potency Versus Linezolid Against Gram-Positive And Fastidious Gram-Negative Pathogens. The Compounds Are Also Active Against Linezolid-And Ciprofloxacin-Resistant Staphylococcus Aureus And Enterococcus Faecium Strains. The Moa For These New Antimicrobials Is Consistent With A Combination Of Protein Synthesis And Gyrase A/topoisomerase Iv Inhibition,With A Structure-Dependent Degree Of The Contribution From Each Inhibitory Mechanism. (C) 2003 Elsevier Ltd. All Rights Reserved.
Doi:10.1016/j.Bmcl.2003.07.021

专利信息

专利号:US-6743811-B2
优先权日:1999-07-28
标 题:Oxazalidinone compounds and methods of preparation and use thereof
发明人：GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; GADWOOD ROBERT C
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. Oxazolidinones as disclosed herein can be readily synthesized and used in a variety of applications including use as antimicrobial agents. In one embodiment, a variety of thioamidomethyloxazolidinones and methods for their synthesis and use are provided.

专利号:US-6531470-B1
优先权日:1998-01-23
标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人：GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

专利号:US-6562844-B2
优先权日:1998-01-23
标 题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人：GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

专利号:US-7002020-B1
优先权日:1998-01-23
标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人：GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.