CAS: 123148-78-7; 4-Chloro-5-Iodo-7H-Pyrrolo[2,3-D]Pyrimidine

相似化合物

1244855-76-2 1012785-51-1 3680-69-1

上下游产品

CAS号3680-69-1 6-氯-7-氮杂嘌呤 | CAS号516-12-1 N-碘代丁二酰亚胺 | CAS号3680-71-5 4-羟基吡咯并[2,3-d]嘧啶 | CAS号52133-67-2 2-氰基-4,4-二乙氧基丁酸乙酯 | CAS号7400-05-7 6-氨基-5-(2,2-二乙氧... | CAS号67831-84-9 2-疏基-7h-吡咯并[2,3... | CAS号213744-81-1 4-氯-5-碘-7-异丙基-7... | CAS号24391-41-1 4-氯-7H-吡咯[2,3-D... | CAS号24386-93-4 5-碘代杀结核菌素 | CAS号24386-91-2 7H-Pyrrolo[2,3-... | CAS号677299-08-0 2-(4-chloro-7H-...

4-羟基吡咯并[2,3-D]嘧啶置于n-碘代丁二酰亚胺,三氯氧磷体系中,用 N,N-二甲基甲酰胺 用作溶剂,化学反应 5.0H,反应生成4-氯-5-碘-7H-吡咯并[2,3-D]嘧啶
参考文献:First Total Synthesis Of A Naturally occurring Iodinated 5'-Deoxyxylofuranosyl Marine Nucleoside
标题:First Total Synthesis Of A Naturally occurring Iodinated 5'-Deoxyxylofuranosyl Marine Nucleoside
摘要:研究人员从蛔虫(diplosoma Sp.)中分离出了一种不寻常的天然海洋核苷--4-氨基-7-(5'-脱氧-β-D-羟基呋喃糖基)-5-碘吡咯并[2,3-D]嘧啶1,该核苷由d-木糖经7个步骤合成,10克的总收率为28%.关键步骤是 5-碘-吡咯并[2,3-D]嘧啶与 5-脱氧-1,2-O-二乙酰基-3-O-苯甲酰基-D-氧基呋喃糖的沃布吕根糖基化.其绝对构型已得到确认.
Doi:10.3390/md10040881

专利信息

专利号:US-2012156680-A1
优先权日:2005-10-31
标 题 :Synthesis of four-color 3'-o-allyl modified photocleavable fluorescent nucleotides and related methods

专利号:US-8183216-B2
优先权日:2007-09-24
标题:Nucleoside derivatives as inhibitors of viral polymerases
发明人：DI FRANCESCO MARIA EMILIA; SUMMA VINCENZO; DESSOLE GABRIELLA
权利人:DI FRANCESCO MARIA EMILIA; SUMMA VINCENZO; DESSOLE GABRIELLA; ANGELETTI P IST RICHERCHE BIO
摘要:A class of nucleoside derivatives of formula (I), as defined herein, that are useful as inhibitors of RNA-dependent RNA viral replication and in particular HCV replication, are provided. Also provided are processes for the synthesis and use of such compounds for treating or preventing HCV infection. formula (I).

专利号:US-2010041029-A1
优先权日:2005-10-31
标 题:Synthesis of four color 3'o-allyl, modified photocleavable fluorescent nucleotides and related methods

专利号:US-2016208313-A1
优先权日:2005-10-31
标 题 :Synthesis of four-color 3'-o-allyl modified photocleavable fluorescent nucleotides and related methods

专利号:US-10907194-B2
优先权日:2005-10-31
标题 :Synthesis of four-color 3′-O-allyl modified photocleavable fluorescent nucleotides and related methods

专利号:US-7982029-B2
优先权日:2005-10-31
标题 :Synthesis of four color 3′O-allyl, modified photocleavable fluorescent nucleotides and related methods