CAS: 1207714-41-7; M-Toluenesulfonyl-Urea
- 相似结构搜索
- InChIKey: TYMBLCCPQXGEHE-UHFFFAOYSA-N
- 计算化学: 氢键受体数3.0氢键供体数2.0可旋转键数2.0
MSDS等安全信息
合成工艺路线路线简述
📜在 甲烷磺酸,氨体系中,化学反应生成格列齐特杂质12
参考文献:Sulfonylureido Thiazoles As Fructose-1,6-Bisphosphatase Inhibitors For The Treatment Of Type-2 Diabetes
标题:Sulfonylureido Thiazoles As Fructose-1,6-Bisphosphatase Inhibitors For The Treatment Of Type-2 Diabetes
摘要:Sulfonylureido Thiazoles Were Identified From A Hts Campaign And Optimized Through A Combination Of Structure-Activity Studies,X-Ray Crystallography And Molecular Modeling To Yield Potent Inhibitors Of Fructose-1,6-Bisphosphatase. Compound 12 Showed Favorable Adme Properties,For Example,F=70%,And A Robust 32% Glucose Reduction In The Acute Db/db Mouse Model For Type-2 Diabetes.
Doi:10.1016/j.Bmcl.2009.11.093
参考文献:Sulfonylureido Thiazoles As Fructose-1,6-Bisphosphatase Inhibitors For The Treatment Of Type-2 Diabetes
标题:Sulfonylureido Thiazoles As Fructose-1,6-Bisphosphatase Inhibitors For The Treatment Of Type-2 Diabetes
摘要:Sulfonylureido Thiazoles Were Identified From A Hts Campaign And Optimized Through A Combination Of Structure-Activity Studies,X-Ray Crystallography And Molecular Modeling To Yield Potent Inhibitors Of Fructose-1,6-Bisphosphatase. Compound 12 Showed Favorable Adme Properties,For Example,F=70%,And A Robust 32% Glucose Reduction In The Acute Db/db Mouse Model For Type-2 Diabetes.
Doi:10.1016/j.Bmcl.2009.11.093
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
合成参考文献
合成方法参考DOI号:10.1016/j.bmcl.2009.11.093
📝 需求与反馈
尽可能描述清楚需求与问题信息
