CAS: 1205-08-9; Methyl 2-Benzamidoacetate

该化合物是化学配方C10H11NO3的芳香混合物,其特点是,在河马净化酸结构中有一个附属于甲基组,由苯环,碳球酸和一个矿类组成,该化合物一般没有色素,可粉色黄色液体,有温和的气味;甲基河马净化物在有机溶剂中溶解,水中表现出中等溶解性;主要用于分析化学领域,作为甲苯的代谢物,作为接触该溶剂的生物标志;此外,它还用于各种有机化合物的合成,并可能参与体内的代谢过程;一般认为甲基河马酸盐毒性较低,但仍需管理接触以避免潜在的健康风险;其特性使得它与环境监测和毒理学研究相关.

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物理性质

MSDS等安全信息

欧盟法规

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合成工艺路线路线简述

    📜Methyl 2-(2-Mercaptobenzamido)Acetate置于molybdenum Hexacarbonyl体系中,用 丙酮 用作溶剂,化学反应 6.0H,以74%的收率获得n-苯甲酰基甘氨酸甲酯
    参考文献:钼介导的硫醇和二硫化物脱硫
    标题:钼介导的硫醇和二硫化物脱硫
    摘要:我们已经成功地实现了六羰基钼 [mo(Co)6] 介导的硫醇和二硫化物的脱硫.在该反应中,芳基,苄基,伯和仲烷基硫醇的巯基 (Sh) 巯基以及二硫化物的 S-S 单键可以被去除.该反应具有高官能团耐受性且不受空间位阻影响.丙酮-D 6 反应的结果表明,硫醇和二硫化物脱硫中的氢源分别是巯基和丙酮(溶剂)的氢原子,脱硫通过形成一种有机钼物种.
    Doi:10.1055/s-0034-1378315

    海关参考信息

    专利信息


    专利号:US-4710583-A
    优先权日:1985-10-21
    标 题:Dipeptides and process
    发明人：CHMURNY ALAN B; GROSS AKIVA T; KUPPER ROBERT J; ROBERTS ROWENA L
    权利人:GRACE W R & CO
    摘要:Synthesis of phenylserine ester (a) via benzaldehyde and glycine ester using serine hydroxymethyltransferase; and (b) via methyl benzoylacetate. Synthesis of hydroxy-aspertame or derivative by enzymatic coupling of phenylserine or derivative with aspertic acid or derivative. Hydrogenation of the coupled product to give as final product aspertame or analog with related processes and products.

    专利号:US-4810817-A
    优先权日:1985-10-21
    标题 :Aspartyl-beta substituted phenylalanine dipeptides
    发明人：CHMURNY ALAN B; GROSS AKIVA T; KUPPER ROBERT J; ROBERTS ROWENA L
    权利人:GRACE W R & CO
    摘要:Synthesis of phenylserine ester (a) via benzaldehyde and glycine ester using serine hydroxymethyltransferase; and (b) via methyl benzoylacetate. Synthesis of hydroxy-aspartame or derivative by enzymatic coupling of phenylserine or derivative with aspartic acid or derivative. Hydrogenation of the coupled product to give as final product aspartame or analog with related processes and products.

    专利号:US-4873359-A
    优先权日:1985-10-21
    标题:Process for preparing as partyl-phenylalanine dipeptides
    发明人：CHMURNY ALAN B; GROSS AKIVA T; KUPPER ROBERT J; ROBERTS ROWENA L
    权利人:GRACE W R & CO
    摘要:Synthesis of phenylserine ester (a) via benzaldehyde and glycine ester using serine hydroxymethyltransferase; and (b) via methyl benzoylacetate. Synthesis of hydroxy-aspartame or derivative by enzymatic coupling of phenylserine or derivative with aspartic acid or derivative. Hydrogenation of the coupled product to give as final product aspartame or analog with related processes and products.

    专利号:US-3334083-A
    优先权日:1963-03-06
    标题:Use of bifunctional nitrogen heterocycles as catalysts in the synthesis of compounds having an amide bond
    发明人：CHRISTIAAN BEYERMAN HUGO; BRINK WILLEM MAASSEN V D
    权利人:ORGANON

    专利号:DE-1518058-A1
    优先权日:1963-03-06
    标 题:Process for the synthesis of compounds with amide bonds

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    合成参考文献


    摘要:Zhang, H.; Liu, C.; Lei, A., Science of Synthesis: Catalytic Transformations via CH Activation, (2015) 2, 162.
    参考文献:10.3389/fnut.2022.822033
    摘要:Yin S, Tao Y, Jiang Y, Meng L, Zhao L, Xue X, Li Q, Wu L. A Combined Proteomic and Metabolomic Strategy for Allergens Characterization in Natural and Fermented Brassica napus Bee Pollen. Front Nutr. 2022;9():822033.
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