CAS: 113402-31-6; 4,4',4''-Methanetriyltribenzonitrile

相似化合物

519-73-3 548-61-8 603-48-5

上下游产品

4,4',4''-tricyanotriphenylmethanol

三(4-氰基苯基)甲醇置于三乙基硅烷,三氟化硼乙醚体系中,用 二氯甲烷 用作溶剂,化学反应 6.0H,以100%的收率获得4,4',4''-亚甲基三苯甲腈
参考文献:如何操纵具有孤立苯基环的简单 Aiegens 的空间共轭和团簇发光
标题:如何操纵具有孤立苯基环的简单 Aiegens 的空间共轭和团簇发光
摘要:除了传统的键合共轭 (Tbc) 之外,空间共轭 (Tsc) 逐渐被证明是光物理过程中的另一个重要相互作用,尤其是最近对非共轭分子团簇发光的观察.然而,与共轭发色团中的 Tbc 不同,操纵 Tsc 和簇发光仍然具有挑战性.本文合成了简单的非共轭三苯甲烷(tpm)及其具有给电子和吸电子基团的衍生物,并系统地研究了它们的光物理性质.由于分子内 Tsc,Tpm 以可见的团簇发光为特征.实验和理论结果表明,由于 Tsc 的电子密度增加和稳定性,将给电子基团引入 Tpm 可以使波长红移并同时提高团簇发光效率.然而,由于剧烈的激发态分子内运动和分子间光致电子转移过程,具有吸电子基团的 Tpm 衍生物表现出低效甚至猝灭的团簇发光.这项工作提供了一种可靠的策略来操纵 Tsc 和团簇发光.由于剧烈的激发态分子内运动和分子间光致电子转移过程,具有吸电子基团的 Tpm 衍生物表现出低效甚至猝灭的团簇发光.这项工作提供了一种可靠的策略来操纵
Doi:10.1021/jacs.1C03882

专利信息

专利号:WO-2010146391-A1
优先权日:2009-06-15
标题:Regioselective synthesis of letrozole
发明人：GORE VINAYAK GOVIND; SHUKLA VINAY KUMAR; BHANDARI SHERYAS; HASBE SURESH; MEKDE SANDEEP
权利人:GENERICS UK LTD; MYLAN INDIA PRIVATE LTD; GORE VINAYAK GOVIND; SHUKLA VINAY KUMAR; BHANDARI SHERYAS; HASBE SURESH; MEKDE SANDEEP
摘要:The present invention relates to an improved process for the preparation of letrozole (I) and its pharmaceutically acceptable salts, to compositions comprising letrozole or a pharmaceutically acceptable salt thereof, and to uses of such compositions. In particular it relates to a process and to novel intermediates for preparing letrozole and its salts substantially free from regioisomeric impurities.

专利号:US-7705159-B2
优先权日:2005-07-06
标题:Process for the preparation of letrozole
发明人：MACDONALD PETER LINDSAY; BIGATTI ETTORE; ROSSETTO PIERLUIGI; HAREL ZVI
权利人:SICOR INC
摘要:The invention provides a high-yield process for the preparation of letrozole having a high purity, without the need for removal of the 4-[1-(1,3,4-triazolyl)methyl]benzonitrile impurity at the intermediate stage. The invention also provides a process for the synthesis of letrozole in which formation of the impurity 4-[1-(1,3,4-triazolyl)methyl]benzonitrile during the first stage is minimized. In the process, a 4-(halomethyl)benzonitrile is reacted with a salt of 1H-1,2,4-triazole, reducing the formation of the impurity. Preferably, the preparation is conducted as a one-pot process.