1-Cbz-4-哌啶甲酸甲酯置于lithium Hydroxide体系中,用 甲醇 用作溶剂,化学反应 24.0H,反应生成N-Cbz-哌啶-4-羧酸 参考文献:Discovery Of Potent Non-Urea Inhibitors Of Soluble Epoxide Hydrolase 标题:Discovery Of Potent Non-Urea Inhibitors Of Soluble Epoxide Hydrolase 摘要:Soluble Epoxide Hydrolase (Seh) Is A Novel Target For The Treatment Of Hypertension And Vascular Inflammation. A New Class Of Potent Non-Urea Seh Inhibitors Was Identified Via High Throughput Screening (Hts) And Chemical Modification. Ic(50)S Of The Most Potent Compounds Range From Micromolar To Low Nanomolar. (C) 2008 Elsevier Ltd. All Rights Reserved. Doi:10.1016/j.Bmcl.2008.09.066
专利号:US-5712269-A 优先权日:1993-04-05 标题 :M2 receptor ligand for the treatment of neurological disorders 发明人:MCCABE R TYLER; WILSON BRYAN R; RHODES CHRISTOPHER A 权利人:PHARMACEUTICAL DISCOVERY CORP 摘要:Muscarinic M2 receptor ligands are described which are suitable for the treatment of neurological disorders, and which may be administered with minimal side-effects. A method of synthesis of these compounds is also described.
专利号:US-12441733-B2 优先权日:2018-03-26 标题:Substituted 2,4-dioxotetrahydropyrimidines as intermediates in the synthesis of bruton's tyrosine kinase inhibitors 发明人:ARISTA LUCA; HEBACH CHRISTINA; HOLLINGWORTH GREGORY JOHN; HOLZER PHILIPP; IMBACH-WEESE PATRICIA; LORBER JULIEN; MACHAUER RAINER; SCHMIEDEBERG NIKO; VULPETTI ANNA; ZOLLER THOMAS 权利人:NOVARTIS AG 摘要:The invention relates to compounds of the formulae (I), (III), (IIIa), (XXIa), (XXIII), and/or (XLVI)or a pharmaceutically acceptable salt thereof, wherein the substituents are as defined in the specification; to intermediates in the preparation of the compounds, to pharmaceutical compositions comprising the compounds and to use of the compounds in the treatment of disease.
专利号:RU-2095339-C1 优先权日:1991-10-17 标 题:Hydroquinone derivatives as free or salt, methods of their synthesis, piperidine derivatives and methods of their synthesis
专利号:US-2008280933-A1 优先权日:2006-07-25 标 题:Benzimidazolyl compounds 发明人:EFREMOV IVAN; ROGERS BRUCE N; DUPLANTIER ALLEN J; ZHANG LEI; ZHANG QIAN; MAKLAD NOHA S; EVRARD EDELWEISS; BRODNEY MICHAEL A 权利人:EFREMOV IVAN; ROGERS BRUCE N; DUPLANTIER ALLEN J; ZHANG LEI; ZHANG QIAN; MAKLAD NOHA S; EVRARD EDELWEISS; BRODNEY MICHAEL A 摘要:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I n n n n n n n n n n as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.
专利号:US-2008312271-A1 优先权日:2006-07-25 标 题 :Azabenzimidazolyl compounds 发明人:EFREMOV IVAN; ROGERS BRUCE N; DUPLANTIER ALLEN J; ZHANG LEI; ZHANG QIAN; MAKLAD NOHA S 权利人:PFIZER 摘要:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I n n n n n n n n n n as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.