CAS: 10230-61-2; (4,5-Dimethyl-1,2-Phenylene)Dimethanethiol

上下游产品

1,2-bis(chloromethyl)-4,5-dimethylbenzene thiourea -2,3-dithiin6,7-dimethylbenz-2,3-dithiin o-xylene 1,2-bis(2-aminoethylthiomethyl)-4,5-dimethylbenzene ethylthiomethyl>-4,5-dimethylbenzene1,2-bis2-(2-carbomethoxyethyl)aminoethylthiomethyl-4,5-dimethylbenzene 2-(7,8-Dimethyl-3-phenyl-1,5-dihydro-benzo[e][1,3]dithiepin-3-yl)-1-thiophen-2-yl-ethanone (E)-3-[4,5-Dimethyl-2-((E)-3-oxo-1-phenyl-3-thiophen-2-yl-propenylsulfanylmethyl)-benzylsulfanyl]-3-phenyl-1-thiophen-2-yl-propenone

📜6,7-Dimethylbenz-2,3-Dithiin置于dl-Dithiothreitol体系中,用 氘代甲醇,重水 用作溶剂,化学反应生成杜烯-α1,α2-二硫醇
参考文献:硫醇-二硫化物交换的结构-反应性关系
标题:硫醇-二硫化物交换的结构-反应性关系
摘要:平衡常数由 36 个二硫醇和三硫醇与衍生自 2-巯基乙醇或二硫苏糖醇的二硫化物之间的硫醇-二硫化物交换确定.反应在甲醇-D/水性缓冲液 (Ph 7) 或甲醇中进行,在 25oc 下,使用 NMR 光谱跟踪反应.这些数据用于根据还原电位对二硫醇进行排序并推断其结构氧化时由它们形成的二硫化物.二硫醇的还原能力与氧化时形成的含二硫化物环的大小之间存在普遍的相关性:形成六元环的二硫醇还原性最强(k = 103-105 M 相对于氧化的 2-巯基乙醇);五元和七元环的还原性降低约 1 个数量级.类似于 1 的化合物,2-乙二硫醇在相对稀释的溶液 (-1 Mm) 中形成环状双(二硫化物)二聚体,但在较高浓度下聚合.其他类别的二硫醇在氧化时形成聚合物.
Doi:10.1021/ja00256A040

专利信息

专利号:US-2009111737-A1
优先权日:1999-05-24
标题:Novel antibacterial agents
发明人：CHRISTENSEN BURTON G; MORAN EDMUND J; GRIFFIN JOHN H; JUDICE J KEVIN; MU YONGQI; PACE JOHN L; MAMMEN MATHAI; AGGEN JAMES
权利人:CHRISTENSEN BURTON G; MORAN EDMUND J; GRIFFIN JOHN H; JUDICE J KEVIN; MU YONGQI; PACE JOHN L; MAMMEN MATHAI; AGGEN JAMES
摘要:This invention relates to novel multibinding compounds (agents) that are antibacterial agents. The multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligands in their monovalent (i.e., unlinked) state have the ability to bind to a an enzyme involved in cell wall biosynthesis and metabolism, a precursor used in the synthesis of the bacterial cell wall and/or the bacterial cell surface thereby interfere with the synthesis and/or metabolism of the cell wall. In particular the multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligands hasn a ligand domain capable of binding to penicillin binding proteins, a transpeptidase enzyme, a substrate of a transpeptidase enzyme, a beta-lactamase enzyme, pencillinase enzyme, cephalosporinase enzyme, a transglycoslase enzyme, or a transglycosylase enzyme substrate; Preferably, the ligands are selected from the beta lactam or glycopeptide class of antibacterial agents.

专利号:US-7179794-B2
优先权日:1998-06-08
标题 :Multivalent macrolide antibiotics
发明人：GRIFFIN JOHN H; PACE JOHN L
权利人:THERAVANCE INC
摘要:Disclosed are multibinding compounds which include macrolide antibiotics, aminoglycosides, lincosamides, oxazolidinones, streptoramins, tetracycline and/or other compounds which bind to bacterial ribosomal RNA and/or to one or more proteins involved in ribosomal protein synthesis in the bacterium, which are useful in treating bacterial infections. The compounds adversely affect protein expression and have an antibacterial effect. The multibinding compounds of this invention containing from 2 to 10 ligands covalently attached to one or more linkers. Each ligand is macrolide antibiotic, aminoglycoside, lincosamide, oxazolidinone, streptogramin, tetracycline or other compound which binds to bacterial ribosomal RNA and/or one or more proteins involved in ribosomal protein synthesis in the bacterium.