CAS: 7073-94-1; 1-Bromo-2-Isopropylbenzene

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异丙苯酚置于五溴化磷体系中,化学反应生成 1-溴-2-异丙基苯
参考文献:The Effects Of Growth Hormone Replacement Therapy On Bone Metabolism In Adult-Onset Growth Hormone Deficiency: A 2-Year Open Randomized Controlled Multicenter Trial
标题:The Effects Of Growth Hormone Replacement Therapy On Bone Metabolism In Adult-Onset Growth Hormone Deficiency: A 2-Year Open Randomized Controlled Multicenter Trial
摘要:成人生长激素缺乏症(ghd)患者表现出骨量显著减少和骨折率增加.生长激素(gh)替代治疗能够增加骨代谢率.关于骨矿含量(bmc)和骨密度(bmd)的长期数据主要来自于开放式的非对照试验,涉及患者人数有限.为了确定尽管骨代谢率增加但长期gh治疗是否对骨骼有益,研究将100名(59名男性和41名女性),年龄介于25至65岁(平均年龄49.7岁)且具有成年起病ghd的患者随机分配至gh治疗组(40名男性和28名女性;平均剂量为0.18 Iu/kg每周)或未治疗对照组(19名男性和13名女性),持续24个月.尽管gh治疗组男性和女性患者的骨代谢参数(骨钙素[oc],I型前胶原羧端前肽[picp],和吡啶醇[pyd])与对照组相比均有类似的增加,但通过双能x射线吸收测定法评估的bmc和bmd的效果在性别上有所差异.与对照组的变化相比,男性gh治疗组患者的脊柱bmc和bmd及总髋bmd显著增加,超远端桡骨bmd则有所减少(24个月的平均+/-标准误变化:+6.8 +/-1.1%,P = 0.009;+5.1 +/-0.8%,P = 0.005;+3.5 +/-0.7%,P = 0.02;和−2.6 +/-0.8%,P = 0.008).在女性患者中未观测到显著的治疗效果.尽管gh治疗导致总重塑空间增加,成年起病ghd的长期gh治疗对骨平衡有积极影响,在两年内能够维持女性的骨量,甚至在男性中增加骨量.
DOI:10.1359/jbmr.2002.17.6.1081

专利信息

专利号:US-8058477-B2
优先权日:2006-03-21
标 题 :Process for the synthesis of arylamines from the reaction of an aromatic compound with ammonia or a metal amide
发明人：HARTWIG JOHN F; SHEN QILONG
权利人:HARTWIG JOHN F; SHEN QILONG; UNIV YALE
摘要:A catalytic process for the synthesis of aromatic primary amines, reagent compositions for effecting the process, and transition metal complexes useful in the process, are provided.

专利号:US-2023295139-A1
优先权日:2020-07-21
标题 :Synthesis of heterocyclic compounds from carboxamide and carboxamide derivatives with haloalkanols

专利号:US-2009234126-A1
优先权日:2006-03-21
标 题:Process for the Synthesis of Arylamines from the Reaction of an Aromatic Compound with Ammonia or a Metal Amide

专利号:JP-2009530403-A
优先权日:2006-03-21
标 题 :Synthesis of arylamines from reactions of aromatic compounds with ammonia or metal amides.

专利号:CA-2646978-A1
优先权日:2006-03-21
标 题:Process for the synthesis of arylamines from the reaction of an aromaticcompounds with ammonia or a metal amide

专利号:WO-2007109365-A2
优先权日:2006-03-21
标题 :Process for the synthesis of arylamines from the reaction of an aromatic compound with ammonia or a metal amide