CAS: 66251-18-1; (1R,3Ar,7Ar)-1-[(1R)-1,5-Dimethylhexyl]Octahydro-7A-Methyl-4H-Inden-4-One

相似化合物

33813-99-9 124905-24-4 83076-51-1

📜维生素 D3置于吡啶,碳酸氢钠,戴斯-马丁氧化剂,臭氧体系中,用 甲醇,二氯甲烷 作为反应溶剂,化学反应 19.5H,反应生成 艾地骨化醇中间体
参考文献:1α,25-二羟基-2β-(3-羟基丙氧基)维生素d 3(ed-71)的全合成
标题:1α,25-二羟基-2β-(3-羟基丙氧基)维生素d 3(ed-71)的全合成
摘要:已经开发了用于合成ed-71的收敛方法.从所报道的易于制备d-甘露醇的环氧化物5开始,Ed-71以11个线性步骤合成,总收率为17%.
DOI:10.1016/j.Tet.2020.131081

专利信息

专利号:US-5292977-A
优先权日:1992-02-05
标题:Palladium catalyzed alkylative cyclization useful in synthesis of vitamin D and analogues
发明人：TROST BARRY M; DUMAS JACQUES
权利人:UNIV LELAND STANFORD JUNIOR
摘要:An alkylative cycloaddition method is provided that is particularly useful for the synthesis of many of the Vitamin D analogues with differing side chains. Thus, a preferred synthesis is of Vitamin D analogues having a side chain R 1 where a substantially geometrically pure first precursor having the structure ##STR1## and a second precursor are provided, the second precursor being a 1,7 enyne. These precursors are reacted in the presence of a palladium catalyst to form compounds having the structure ##STR2## where R 2 hydrogen, hydroxyl, lower alkoxy, fluorine, or a protecting group, and R 3 is hydrogen, hydroxyl, lower alkoxy, fluorine, or a protecting group.

专利号:US-5446225-A
优先权日:1992-02-05
标题:Palladium catalyzed akylative cyclization useful in syntheses of Vitamin D and analogues
发明人：TROST BARRY M; DUMAS JACQUES
权利人:UNIV LELAND STANFORD JUNIOR
摘要:An alkylative cycloaddition method is provided that is particularly useful for the synthesis of many of the Vitamin D analogues with differing side chains. Thus, a preferred synthesis is of Vitamin D analogues having a side chain R 1 where a first precursor having the structure ##STR1## with X being a halide or a pseudo halide, and a second precursor are provided, the second precursor being a 1,7 enyne. These precursors are reacted in the presence of a palladium catalyst to form compounds having the structure ##STR2## where R 2 is hydrogen, hydroxyl, lower alkoxy, fluorine, or a protecting group, and R 3 is hydrogen, hydroxyl, lower alkoxy, fluorine, or a protecting group.

专利号:EP-1494680-B1
优先权日:2002-03-25
标题 :Use of carbon-2-modified-vitamin d analogs to induce the formation of new bone
发明人：DELUCA HECTOR F; PIKE J WESLEY; SHEVDE NIRUPAMA K
权利人:WISCONSIN ALUMNI RES FOUND
摘要:It has been discovered that the 2-carbon-modified derivatives of 1α,25-dihydroxyvitamin D3 specifically stimulate osteoblasts to form new bone. The ability of the 2-carbon-modified vitamin D analogs to stimulate new bone formation suggest that these compounds can be used where synthesis of new bone is required. Thus, these compounds can be used either systemically or locally to stimulate the growth of bone transplants, to increase the rate of fracture healing and thereby reduce the time required for the healing of fractures, the stimulation of bone growth when required for replacement surgery, and also for the growth of bone to implants or other devices required to maintain the skeleton or teeth in the proper positions.

专利号:CA-2561590-C
优先权日:2004-04-02
标题 :Novel method for the preparation of intermediates useful for the synthesis of vitamin d analogues

专利号:WO-2005095336-A2
优先权日:2004-04-02
标 题 :Novel method for the preparation of intermediates useful for the synthesis of vitamin d analogues

专利号:EP-1735276-A2
优先权日:2004-04-02
标题:Novel method for the preparation of intermediates useful for the synthesis of vitamin d analogues