CAS: 6214-64-8; Ethyl 2-Hydroxy-4-Methylpyrimidine-5-Carboxylate

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ethyl 2-acetyl-3-ureido-2-propenoate 6-methyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester ethyl 4-(trichloro-methyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate ethyl acetoacetateethyl 5-methyl-1-phenyl-1H-pyrazole-4-carboxylate 3-methyl-1-phenyl-1H-pyrazole-4-carboxylic acid ethylester 4-methyl-2-oxo-1H-pyrimidine-5-carboxylic acid ethyl 4,6-dimethyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

乙酰乙酸乙酯置于硝酸,氯化铵体系中,化学反应 3.5H,反应生成 4-甲基-2-羟基嘧啶-5-羧酸乙酯
参考文献:Synthesis Of 4-Aminoquinoline-pyrimidine Hybrids As Potent Antimalarials And Their Mode Of Action Studies
标题:Synthesis Of 4-Aminoquinoline-pyrimidine Hybrids As Potent Antimalarials And Their Mode Of Action Studies
摘要:One Of The Most Viable Options To Tackle The Growing Resistance To The Antimalarial Drugs Such As Artemisinin Is To Resort To Synthetic Drugs. The Multi-Target Strategy Involving The Use Of Hybrid Drugs Has Shown Promise. In Line With This,New Hybrids Of Quinoline With Pyrimidine Have Been Synthesized And Evaluated For Their Antiplasmodial Activity Against Both Cq(S) And Cq(R) Strains Of Plasmodium Falciparum. These Depicted Activity In Nanomolar Range And Were Found To Bind To Heme As Well As At Rich Puc18 Dna. (C) 2013 Elsevier Masson Sas. All Rights Reserved.
DOI:10.1016/j.Ejmech.2013.05.046