CAS: 598-39-0; 1,1-Difluoro-2-Iodoethane

上下游产品

CAS号359-07-9 1-溴-2,2-二氟乙烷 | CAS号75-02-5 氟化乙烯 | CAS号430-66-0 1,1,2-三氟乙烷 | CAS号381-73-7 二氟乙酸 | CAS号75-02-5 氟化乙烯

氟化乙烯置于n-Jod-Bis(Trifluormethyl)-Amin体系中,化学反应 24.0H,反应生成 1,1-二氟-2-碘乙烷
参考文献:氮的多氟烷基衍生物.xxx部分.的反应ñ-Chlorobistrifluoromethylamine与丙烯和氟乙烯和ñ-Iodobistrifluoromethylamine与离子条件下氟乙烯
标题:氮的多氟烷基衍生物.xxx部分.的反应ñ-Chlorobistrifluoromethylamine与丙烯和氟乙烯和ñ-Iodobistrifluoromethylamine与离子条件下氟乙烯
摘要:N-氯双三氟甲胺与丙烯的反应在假定涉及离子中间体的条件下(黑暗中为-24°)以60的比例反应生成2-氯-1-甲基-Nn-双三氟甲基乙胺和2-氯-Nn-双三氟甲基丙胺的混合物: 40.氟乙烯与n-碘胺在相同条件下反应,主要反应生成1-氟-2-碘-Nn-双三氟甲基乙胺以及少量的2-氟-2-碘-Nn-双三氟甲基乙胺,1,1-二氟-2-碘乙烷和全氟-2-氮杂丙烯.相反,N-氯胺在-24°时不与氟乙烯反应,但在室温下在黑暗中,会在其中形成1:1加合物2-氯-2-氟-和2-氯-1-氟-Nn-双三氟甲基乙胺自由基反应的比例为93:7.
DOI:10.1039/j39710003829

专利信息

专利号:US-10112955-B2
优先权日:2015-10-29
标题 :Isoindoline, azaisoindoline, dihydroindenone and dihydroazaindenone inhibitors of Mnk1 and Mnk2
发明人：SPRENGELER PAUL A; REICH SIEGFRIED H; ERNST JUSTIN T; WEBBER STEPHEN E; SHAGHAFI MIKE; MURPHY DOUGLAS; TRAN CHINH
权利人:EFFECTOR THERAPEUTICS INC
摘要:The present invention provides synthesis, pharmaceutically acceptable formulations and uses of compounds in accordance with Formula I, or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof. n nFor Formula I compounds A 1 , A 2 , A 3 , A 4 , A 5 , W 1 , Y, R 1 , R 2 , R 3 , R 4 , R 5 , R 6a , R 6b , R 7 , R 8 , R 8a , R 8b , R 9 , R 9a , R 9b , and R 10 and subscript “nâ€? are as defined in the specification. The inventive Formula I compounds are inhibitors of Mnk and find utility in any number of therapeutic applications, including but not limited to treatment of inflammation and various cancers.

专利号:US-8003785-B2
优先权日:2008-06-18
标 题 :Halo-substituted pyrimidodiazepines
发明人：CAI JIANPING; CHEN SHAOQING; CHU XIN-JIE; LUK KIN-CHUN; MISCHKE STEVEN GREGORY; SUN HONGMAO; WOVKULICH PETER MICHAEL
权利人:TAKEDA PHARMACEUTICAL
摘要:The present invention provides PLK1 inhibitor compounds of formula I: n nuseful in the treatment or control of cell proliferative disorders, particularly oncological disorders. These compounds and formulations containing such compounds may be useful in the treatment or control of solid tumors, such as, for example, breast, colon, lung and prostate tumors and other oncological diseases such as non-Hodgkin's lymphomas. Also provided are intermediate compounds useful in the synthesis of compounds of formula I.

专利号:WO-2010096722-A1
优先权日:2009-02-20
标 题 :3-oxo-2, 3-dihydro- [1,2, 4] triazolo [4, 3-a]pyridines as soluble epoxide hydrolase (seh) inhibitors
发明人：FENG JUN; KEUNG WALTER; NOTZ WOLFGANG REINHARD LUDWIG
权利人:TAKEDA PHARMACEUTICAL; FENG JUN; KEUNG WALTER; NOTZ WOLFGANG REINHARD LUDWIG
摘要:Claimed are intermediates in the synthesis of N-Arylmethyl-3-Oxo-2,3-dihydro- [1,2,4]triazolo[4,3-a]pyridine-6-carboxamides as well as a process (A) to arrive at 3-Oxo-2, 3-dihydro-[1,2,4]triazolo[4,3-a]pyridine-6-carboxylic acid. The triazolo[4,3-a]pyridine-6-carboxamides of formula (I) are used as soluble epoxide hydrolase inhibitors (sEH) having therapeutic effect in pathologic conditions such as hypertension, stroke, inflammatory processes, diabetes and a variety of cardiovascular diseases.

专利号:US-2025042881-A1
优先权日:2021-10-26
标 题 :Ccr6 receptor modulators
发明人：ALLEMANN OLIVER; CAROFF EVA; HUBLER FRANCIS; MEYER EMMANUEL
权利人:IDORSIA PHARMACEUTICALS LTD
摘要:The present invention relates to compounds of Formula (I), their synthesis and use as CCR6 receptor modulators for the prevention or treatment of e.g. inflammatory/autoimmune diseases/disorders and cancer.

专利号:US-7772246-B2
优先权日:2007-08-01
标题:Pyrazole compounds as RAF inhibitors
发明人：CUI JINGRONG JEAN; DEAL JUDITH GAIL; GU DANLIN; GUO CHUANGXING; JOHNSON MARY CATHERINE; KANIA ROBERT STEVEN; KEPHART SUSAN ELIZABETH; LINTON MARIA ANGELICA; MCALPINE INDRAWAN JAMES; PAIRISH MASON ALAN; PALMER CYNTHIA LOUISE
权利人:PFIZER
摘要:The present invention is directed to compounds of Formula (I), n nand to pharmaceutically acceptable salts thereof, their synthesis, and their use as Raf inhibitors.

专利号:CN-105294520-A
优先权日:2015-11-23
标题 :A kind of synthesis technique of 2-(2',2'-difluoroethoxy)-6-trifluoromethylphenylpropyl sulfide