CAS: 5947-49-9; Podocarpic Acid
该化合物是一种复杂的有机化合物,其特征是其多环结构,包括典型的苯丙胺衍生物的多个引信环;该化合物具有氢氧基(-OH)和碳箱酸组(-COOH)的特点,有助于其作为生物活性分子的潜力;国际化联的名称所显示的立体化学化学学表明其原子的具体空间安排能够影响其再活动及其与生物系统的相互作用;甲基组的存在增强了其水恐特性,而氢氧和碳箱酸功能则具有极性特征,允许各种溶剂中的潜在溶液溶解性;这种化合物可能表现出有趣的药性特性,使其在医药化学和天然产品研究中引起兴趣.
- 英文名称Podocarpic Acid
- 中文名称罗汉松酸
- IUPAC名称(1S,4aS,10aR)-6-hydroxy-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthrene-1-carboxylic acid
- 其它别名1-Phenanthrenecarboxylicacid, 1,2,3,4,4a,9,10,10a-°Ctahydro-6-hydroxy-1,4a-dimethyl-, [1S-(1a,4aa,10ab)]-; Pod°Carpa-8,11,13-trien-16-oic acid, 12-hydroxy- (7CI,8CI); (+)-Pod°Carpic acid; (1S)-1,2,3,4,4a,9,10,10a-°Ctahydro-6-hydroxy-1,4a-dimethyl-1-phenanthrenecarboxylicacid; Pod°Carpic acid; Pod°Carpic acid (C17H22O3)
- CAS编号5947-49-9
- MFCD编号:MFCD00074825
- EINECS号:227-706-3
- FDA UNII编号:7K80G5Z96Y
- 分子式:C17H22O3分子量:274.36
- 产品CID: 1571432
- 产品分类有机原料 → 羧酸类化合物及衍生物
物理性质
- 熔点193-196 °C(文献)
- 沸点449.6±45.0 °C(预测)
- 闪点239.8°C
- 密度1.182±0.06 g/cm3(预测)
- PH:20546 +165° (c = 4 in abs ethanol)
- pKa:4.66±0.40(预测)
- PSA:57.53
- LogP:3.4871
- 折射率1.575
- 溶解性DMSO: ≥ 100 mg/mL (364.50 Mm)
- 敏感性如果遵照规格使用和储存则不会分解，未有已知危险发生 避免强氧化剂
- 外观形态白色至类白色固体
- 储存条件储存在 -20°C
- 产品应用该化合物是一种自然产品,可起到TRPA1活性剂的作用;它作为LXRΑ和LLXET受体的强力活性动力剂(HEK-293细胞中活性为~8至10倍于天然活性LXRA和LXB受体(HEC-293细胞中的IGAND 22-(R)-氢氧胆固醇));它在C. ELEGANS 中激活SKN-1,类似于已知的NRF2活性器,如Α-脂酸(LA);它通过将内生甲基氧和克氧(GO)水平降低至接近野型水平,减轻了NLD-4变异体的致病性苯型.
MSDS等安全信息
上下游产品
CAS号1231-74-9 甲基 O-甲基罗汉松酸酯 | CAS号125446-62-0 magnesium,1-eth... | CAS号123427-81-6 (3S)-3-[(1R)-3-... | CAS号832-69-9 1-甲基菲 | CAS号111589-13-0 8-Methyl-[3]phe... | CAS号81801-25-4 3a-hydroperoxy-... | CAS号40061-88-9 1-Phenanthrenec...合成工艺路线路线简述
📜Methyl Podocarpate置于aluminum Tri-Bromide,乙硫醇体系中,化学反应 5.5H,以98%的收率获得产物罗汉松酸
参考文献:Hard Acid And Soft Nucleophile Systems. 3. Dealkylation Of Esters With Aluminum Halide-Thiol And Aluminum Halide-Sulfide Systems
标题:Hard Acid And Soft Nucleophile Systems. 3. Dealkylation Of Esters With Aluminum Halide-Thiol And Aluminum Halide-Sulfide Systems
摘要:
DOI:10.1021/jo00323A004
海关参考信息
- 2902600000-乙苯
2902700000-异丙基苯
2905121000-正丙醇
2912110000-甲醛 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.
专利号:WO-2013070912-A1
优先权日:2011-11-10
标 题 :Synthesis of silicone ionomer membranes and the use thereof
发明人：LU GANG
权利人:DOW CORNING
摘要:The present invention relates to membranes and methods of making and using the same. In some examples, the membrane can be supported or unsupported. The membrane includes a cured product of a modified silicone composition. The modified silicone composition includes (A) a curable silicone composition. The modified silicone composition also includes (B) a salt of a carboxylic acid.
专利号:ES-2295031-T3
优先权日:1999-05-14
标 题:NEW MODULATORS OF INTERLEUCINE-1 AND TUMOR NECROSIS FACTOR, SYNTHESIS OF SUCH MODULATORS AND METHODS OF USE OF SUCH MODULATORS.
专利号:ES-2337264-T3
优先权日:1999-05-14
标题:MODULATORS OF INTERLEUCINE-1 AND THE FACTOR-ALPHA OF TUMOR NECROSIS, SYNTHESIS OF SUCH MODULATORS AND METHODS OF USE OF SUCH MODULATORS.
专利号:JP-H01228938-A
优先权日:1988-03-09
标题 :Asymmetric synthesis of diterpene
专利号:US-9217012-B2
优先权日:2009-04-08
标题 :Inhibitors of protein tyrosine phosphatases
发明人：ZHANG ZHONG-YIN; ZHANG SHENG
权利人:ZHANG ZHONG-YIN; ZHANG SHENG; UNIV INDIANA RES & TECH CORP
摘要:Disclosed herein are compounds that selectively inhibit members of the PTP family of enzymes. Synthesized compounds demonstrated selective inhibition of TC-PTP. Also provided are methods of using the compounds and formulations containing the compounds. Also described is a fluorescence-tagged combinatorial library synthesis and screening method. And methods of using these compounds to effect enzyme activity both in cells and in vitro as well as method of using these compounds to treat diseases in human and animals.
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品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1. Cui, Y.-M., Yasutomi, E., Otani, Y., et al. Design, synthesis and characterization of podocarpate derivatives as openers of BK channels. Bioorg. Med. Chem. Lett. 18(19), 5197-5200 (2008). 2. Chaudhuri, J., Bose, N., Gong, J., et al. A Caenorhabditis elegans model elucidates a conserved role for TRPA1-Nrf signaling in reactive α-dicarbonyl detoxification. Curr. Biol. 26(22), 3014-3025 (2016). 3. Dang, Z., Jung, K., Zhu, L., et al. Phenolic diterpenoid derivatives as anti-influenza a virus agents. ACS Med. Chem. Lett. 6(3), 355-358 (2015). 4. Singh, S.B., Ondeyka, J.G., Liu, W., et al. Discovery and development of dimeric podocarpic acid leads as potent agonists of liver X receptor with HDL cholesterol raising activity in mice and hamsters. Bioorg. Med. Chem. Lett. 15(11), 2824-2828 (2005).合成参考文献
摘要:Mourad, A. K.; Czekelius, C., Science of Synthesis Knowledge Updates, (2011) 3, 85.
摘要:S109 | PARCEDC | List of 7074 potential endocrine disrupting compounds (EDCs) by PARC T4.2 | DOI:10.5281/zenodo.10944198
摘要:de Figueiredo, R. M., Science of Synthesis: Knowledge Updates, (2024) 2, 291.
参考文献:10.1248/cpb.56.585
摘要:Kuo YJ, Hwang SY, Wu MD, Liao CC, Liang YH, Kuo YH, Ho HO. Cytotoxic constituents from Podocarpus fasciculus. Chem Pharm Bull (Tokyo). 2008 Apr;56(4):585–8. doi: 10.1248/cpb.56.585.
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