CAS: 443-82-3; 1-Fluoro-2,3-Dimethylbenzene

上下游产品

CAS号87-59-2 2,3-二甲基苯胺 | CAS号36018-19-6 2,3-dimethylphe... | CAS号62590-16-3 1,2-Bis(bromome... | CAS号95-47-6 邻二甲苯 | CAS号120-82-1 1,2,4-三氯苯 | CAS号95-47-6 邻二甲苯 | CAS号652-39-1 3-氟邻苯二甲酸酐 | CAS号699-90-1 3-氟-2-甲基苯甲酸 | CAS号52548-00-2 3-溴-6-氟邻二甲苯 | CAS号1736-87-4 3-氟-6-硝基邻二甲苯 | CAS号1737-68-4 4-氟-2,3-二甲基苯胺 | CAS号1583-67-1 3-氟邻苯二甲酸 | CAS号52872-60-3 (2-fluoro-3,4-d... | CAS号62590-16-3 1,2-Bis(bromome... | CAS号51736-79-9 5-fluorobicyclo...

2,3-二甲基苯胺置于盐酸,Sodium Nitrite,氟硼酸钠体系中,用47%的收率获得产物3-氟邻二甲苯
参考文献:Flash Vacuum Pyrolysis Over Magnesium. Part 1. Pyrolysis Of Benzylic,Other Aryl/alkyl And Aliphatic Halides
标题:Flash Vacuum Pyrolysis Over Magnesium. Part 1. Pyrolysis Of Benzylic,Other Aryl/alkyl And Aliphatic Halides
摘要:在玻璃棉上覆盖一层新升华的镁,进行闪式真空热解,能有效促使苄基卤化物耦合反应生成相应的联苄.当有邻位卤素取代基存在时,进一步脱卤反应生成部分二氢蒽和蒽.卤甲基萘和二苯基甲烷也能高效耦合,而三苯基氯甲烷则反应生成4,4'-双(二苯甲基)联苯.用α,α'-二卤代邻二甲苯可以获得较高产率的苯并环丁烯,而异构的α,α'-二卤代对二甲苯,通过形成的对二甲苯的聚合,可以得到一系列高热稳定性的聚合物.其他卤代烃苯大体上会脱卤化氢,某些情况下能产生环化反应.同样可以观测到,苯基卤代烷烃脱去羰基反应生成苯乙炔以及其他产物.简单的烷基卤化物则高效地脱去hcl或hbr反应生成烯烃.脂肪族二卤化物也会发生这一反应反应生成二烯,但不发生环化反应反应生成环烷烃,或在某些情况下发生氢原子转移的脱卤反应反应生成烯烃.5-溴戊-1-烯的产物符合自由基途径的预期,但6-溴己-1-烯并不符合.2,2-二氯丙烷和1,1-二氯丙烷能脱去hcl,但1,1-二氯丁烷,戊烷和己烷则能部分水解,随后脱去hcl,反应生成e,E-,E,Z-和z,Z-异构体二烷-1-烯基醚,并且得到了这些物质的13C NMR全归属数据.6-氯己-1-炔和7-氯庚-1-炔能发生环化反应反应生成亚甲基环烷烃和环炔烃.本文还考察了1,2-二溴环己烷和1,2-二氯环辛烷在上述条件下的行为.本文给出了众多种证据,表明这些反应过程不涉及气相自由基的形成,而是表面吸附的金属有机物种.
DOI:10.1039/b108663D

专利信息

专利号:US-7652178-B2
优先权日:2007-02-26
标题:Perfluoroparacyclophane and methods of synthesis and use thereof
发明人：DOLBIER JR WILLIAM R; XIE PUHUI; KUMAR RAKESH
权利人:SPECIALTY COATING SYSTEMS INC
摘要:A composition comprising perfluoro-[2,2]-paracyclophane dimer compound is disclosed. The synthesis reaction of the paracyclophane dimer from 1,4-bis(chlorodifluoromethane)-2,3,5,6-tetrafluorobenzene involves heating in the presence of a metal catalyst and a solvent. A perfluorinated paraxylylene coating formed from the perfluorinated paracyclophane dimer is also disclosed.

专利号:US-2011104055-A1
优先权日:2002-05-31
标题:Substituted n-aryl benzamides and related compounds for treatment of amyloid diseases and synucleinopathies
发明人：SNOW ALAN; WEIGELE MANFRED; LARSEN LESLEY; NGUYEN BETH; LAKE THOMAS; CASTILLO GERARDO; SANDERS VIRGINIA; WEAVERS REX T; LORIMER STEPHEN; LARSEN DAVID; COFFEN DAVID L; COFFEN CHARLOTTE
权利人:SNOW ALAN; WEIGELE MANFRED; LARSEN LESLEY; NGUYEN BETH; LAKE THOMAS; CASTILLO GERARDO; SANDERS VIRGINIA; WEAVERS REX T; LORIMER STEPHEN; LARSEN DAVID; COFFEN DAVID L; COFFEN CHARLOTTE
摘要:Compounds and their pharmaceutically acceptable salts, their synthesis and labeling, pharmaceutical compositions containing them, and their use in the treatment of amyloid diseases, including Aβ amyloidosis, such as observed in Alzheimer's disease, IAPP amyloidosis, such as observed in type 2 diabetes, and synucleinopathies, such as observed in Parkinson's disease, and the manufacture of medicaments for such treatment are provided. Also provided is the use of the disclosed compounds as imaging agents and methods for in vivo imaging and detection of amyloid and synuclein.

专利号:US-9676721-B2
优先权日:2010-09-03
标题 :Compounds and compositions for the inhibition of NAMPT
发明人：BAIR KENNETH W; BUCKMELTER ALEXANDRE J; HAN BINGSONG; LIN JIAN; REYNOLDS DOMINIC J; SMITH CHASE C; WANG ZHONGGUO; ZHENG XIAOZHANG
权利人:BAIR KENNETH W; BUCKMELTER ALEXANDRE J; HAN BINGSONG; LIN JIAN; REYNOLDS DOMINIC J; SMITH CHASE C; WANG ZHONGGUO; ZHENG XIAOZHANG; FORMA TM LLC
摘要:The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes. An illustrative compound of the invention is shown below.

专利号:US-9555039-B2
优先权日:2011-05-09
标题:Piperidine derivatives and compositions for the inhibition of nicotinamide phosphoribosyltransferase (NAMPT)
发明人：BAIR KENNETH W; BAUMEISTER TIMM R; BUCKMELTER ALEXANDRE J; CLODFELTER KARL H; HAN BINGSONG; KUNTZ JUDITH D; LIN JIAN; REYNOLDS DOMINIC J; SMITH CHASE C; WANG ZHONGGUO; ZHENG XIAOZHANG
权利人:BAIR KENNETH W; BAUMEISTER TIMM R; BUCKMELTER ALEXANDRE J; CLODFELTER KARL H; HAN BINGSONG; KUNTZ JUDITH D; LIN JIAN; REYNOLDS DOMINIC J; SMITH CHASE C; WANG ZHONGGUO; ZHENG XIAOZHANG; FORMA TM LLC
摘要:The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes. An illustrative compound of the invention is shown below: Formula (I)

专利号:US-10270034-B2
优先权日:2014-05-26
标题 :Tetra-aryl indacenodithiophene-based polycyclic polymers and their use
发明人：MITCHELL WILLIAM; D'LAVARI MANSOOR; WANG CHANGSHENG; SPARROWE DAVID
权利人:MERCK PATENT GMBH
摘要:The present invention relates to compounds comprising a tetra-aryl indacenodithiophene-based structural unit, the synthesis of such compounds as well as their use in organic electronic devices. The invention further relates to organic electronic devices comprising such compounds.

专利号:US-9169209-B2
优先权日:2011-05-04
标题:Compounds and compositions for the inhibition of NAMPT
发明人：BAIR KENNETH W; BAUMEISTER TIMM; BUCKMELTER ALEXANDRE J; CLODFELTER KARL H; HAN BINGSONG; LIN JIAN; REYNOLDS DOMINIC J; SMITH CHASE C; WANG ZHONGGUO; ZHENG XIAOZHANG
权利人:BAIR KENNETH W; BAUMEISTER TIMM; BUCKMELTER ALEXANDRE J; CLODFELTER KARL H; HAN BINGSONG; LIN JIAN; REYNOLDS DOMINIC J; SMITH CHASE C; WANG ZHONGGUO; ZHENG XIAOZHANG; FORMA TM LLC
摘要:The present invention relates to compounds and composition for inhibition of NAMPT, their synthesis, applications and antidotes. An illustrative compound of the invention is shown below.