CAS: 41051-15-4; Methyl 4-Methoxy-3-Oxobutanoate

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CAS号32807-28-6 4-氯乙酰乙酸甲酯 | CAS号107-03-9 丙硫醇 | CAS号141-97-9 乙酰乙酸乙酯 | CAS号38330-80-2 丙二酸单甲酯钾盐 | CAS号31059-08-2 1-imidazol-1-yl... | CAS号6290-49-9 甲氧基乙酸甲酯 | CAS号96-32-2 溴乙酸甲酯 | CAS号17790-81-7 Butanoic acid,4... | CAS号124-41-4 甲醇钠 | CAS号325685-59-4 4-氯-6-(甲氧基甲基)-2-苯基嘧啶 | CAS号3122-78-9 6-(甲氧基甲基)嘧啶-4-醇 | CAS号92737-66-1 4-methoxy-6-(me...

4-氯乙酰乙酸甲酯置于盐酸,Sodium Methylate体系中,用 水,乙腈 作为反应溶剂,以91.7%的收率获得产物4-甲氧基乙酰乙酸甲酯
参考文献:Process For The Production Of 4-Alkoxyacetoacetic Acid Esters
标题:Process For The Production Of 4-Alkoxyacetoacetic Acid Esters
摘要:从4-氯或4-溴乙酰乙酸酯制备4-烷氧基乙酰乙酸酯的过程.将4-氯或4-溴乙酰乙酸酯与多于一个当量的碱性醇酸盐在无极溶剂中反应,有效温度为50oc至100oc.

专利信息

专利号:US-2007015260-A1
优先权日:2002-03-14
标 题:Synthesis of synthons for the manufacture of bioactive compounds
发明人：WONG CHI-HUEY; LIU JUNJIE; DESANTIS GRACE; BURK MARK
权利人:SCRIPPS RESEARCH INST
摘要:The present invention is based on the discovery that 2-deoxyribose-5-phosphate aldolase (DERA, EC 4.1.2.4) and variants thereof can be used to catalyze sequential asymmetric aldol reactions between a wide variety of donor and acceptor aldehydes. The reaction products typically contain at least two new stereogenic centers and can be produced in enantiomerically pure form. As such, DERA catalyzed asymmetric aldol chemistry can be exploited to produce synthons for the synthesis of a variety of bioactive molecules.

专利号:US-4841042-A
优先权日:1985-03-19
标 题 :Process for the preparation of carbapenem intermediates
发明人：HAEBICH DIETER; HARTWIG WOLFGANG
权利人:BAYER AG
摘要:A process for the preparation of a 4-[3-carboxy-3-diazo-2-oxopropyl]azetidin-2-one of the formula ##STR1## comprising reacting a 4-acetoxy-2-azetininone of the formula ##STR2## with a compound of the formula ##STR3## in an inert solvent, in the presence of a base and of a silylating agent, in a one-pot process. n Many of the products are new. The products are useful in the synthesis of carbapenem antibiotics.

专利号:WO-2015019310-A1
优先权日:2013-08-07
标 题 :Process for the preparation of dolute-gravir and intermediates thereof
发明人：DANDALA RAMESH; VELLANKI SIVA RAM PRASAD; NADELLA MADHU MURTHY; BALUSU PHANI KUMAR
权利人:MYLAN LAB LTD
摘要:The present disclosure relates to processes for the preparation of dolutegravir or of its pharmaceutically acceptable salts. The present disclosure also provides intermediates useful in the synthesis of dolutegravir.

专利号:US-6642390-B2
优先权日:2001-07-11
标 题:One step synthesis of 1,2,3-triazole carboxylic acids
发明人：KOLB HARTMUTH C; CAVALLARO CULLEN; SHI ZHI-CAI; GONTCHAROV ALEXANDER; WANG ZHI-MIN; RICHARDSON PAUL F; KANAMARLAPUDI RAMANAIAH C
权利人:LEXICON PHARMACEUTICALS INC
摘要:Disclosed is a one step method for preparing a 1,2,3-triazole carboxylic acid by treating an azide with a beta-ketoester in the presence of a base.

专利号:US-2003232416-A1
优先权日:2002-03-14
标题:Synthesis of synthons for the manufacture of bioactive compounds

专利号:US-2003135050-A1
优先权日:2001-07-11
标题 :One step synthesis of 1,2,3-triazole carboxylic acids