CAS: 33225-73-9; 2-Nitropyridine-5-Carboxylic Acid

相似化合物

54973-78-3 33225-72-8 59288-43-6

上下游产品

CAS号1074-38-0 2-硝基-5-甲基吡啶 | CAS号3167-49-5 6-氨基烟酸 | CAS号5326-23-8 6-氯烟酸 | CAS号73781-91-6 6-氯烟酸甲酯 | CAS号18617-50-0 6-羟基烟酸乙酯 | CAS号26218-80-4 6-甲氧基烟酸甲酯

📜6-氨基烟酸置于硫酸,双氧水体系中,化学反应生成 6-硝基烟酸
参考文献:Otsuji Et Al.,Nippon Kagaku Zasshi,1959,Vol. 80,P. 1293,1295
标题:Otsuji Et Al.,Nippon Kagaku Zasshi,1959,Vol. 80,P. 1293,1295

专利信息

专利号:US-5169935-A
优先权日:1990-06-20
标 题:Method of making peptides
发明人：HOEGER CARL A; THEOBALD PAULA G; PORTER JOHN S; RIVIER JEAN E F
权利人:SALK INST FOR BIOLOGICAL STUDI
摘要:Methods for making peptides of a suitable length for solid phase synthesis, which peptides include in their sequence a pair of residues of a different character which have acylated side chains and a residue which has an N-alkylated side chain. A peptide intermediate is constructed on the resin using commercially available starting materials. The N-terminus can be acylated by removing the alpha -amino protecting group and acylating under standard conditions. First primary amino protecting groups included in those residues to be acylated are removed, and acylation is effected, preferably by using a carboxypyridine or a similar heterocyclic acylating agent. Following such side chain acylation, a second protecting group included in the residue to be N-alkylated is removed, and the N-alkylation reaction is carried out while the peptide remains on the resin using a borohydride and an appropriate aldehyde or ketone. Following cleavage from the resin and removal of any protecting groups still remaining, the peptide is appropriately purified, thus requiring only a single purification to be carried out while forming a synthetic peptide including residues for which the modified amino acids are not readily commercially available.

专利号:CN-117510471-A
优先权日:2022-07-29
标题 :A kind of synthesis method of abeciclib