CAS: 303-34-4; Lasiocarpine

• 英文名称Lasiocarpine
• 中文名称毛果天芥菜碱
• IUPAC名称(1S,7aR)-7-((((R)-2,3-dihydroxy-2-((S)-1-methoxyethyl)-3-methylbutanoyl)oxy)methyl)-2,3,5,7a-tetrahydro-1H-pyrrolizin-1-yl (Z)-2-methylbut-2-enoate
• 其它别名Lasiocarpine; 2-Butenoic Acid, 2-Methyl-, 7[[(2,3-Dihydroxy-2-(1-Methoxyethyl)-3-Methyl-1-Oxobutoxy] Methyl]-2,3,5,7A-Tetrahydro-1H-Prrolizin-1-Yl Ester, [1S-[1Alpha(Z), 7(2S*, 3R*), 7Aalpha)]-; (Z)-2-Methyl-2-Butenoic Acid (1S)-7-[[[(2R)-2,3-Dihydroxy-2-[(S)-1-Methoxyethyl]-3-Methylbutanoyl]Oxy]Methyl]-2,3,5,7Aβ-Tetrahydro-1H-Pyrrolizin-1-Yl Ester; 2-Methyl-2-Butenoic Acid 7-[[2,3-Dihydroxy-2-(1-Methoxyethyl)-3-Methyl-1-Oxobutoxy]Methyl]-2,3,5,7A-Tetrahydro-1H-Pyrrolizin-1-Yl Ester; Lasiocarpin
• CAS编号303-34-4
• MFCD编号:MFCD31631257
• EINECS号:805-215-0
• FDA UNII编号:S770100Q96
• 分子式:C21H33NO7分子量:411.49
• 产品CID: 1288000
• 产品分类有机原料 → 生物碱及其衍生物

• 相似结构搜索
• 产品信息参考;;;;
• InChIKey: QHOZSLCIKHUPSU-GTZNJGJUSA-N
• InChI=1S/C21H33NO7/c1-7-13(2)18(23)29-16-9-11-22-10-8-15(17(16)22)12-28-19(24)21(26,14(3)27-6)20(4,5)25/h7-8,14,16-17,25-26H,9-12H2,1-6H3/b13-7-/t14-,16-,17+,21-/m0/s1
• 计算化学: 氢键受体数8.0氢键供体数2.0可旋转键数10.0

物理性质

• 熔点97 °C
• 沸点519.8±50.0 °C at 760 mmHg
• 闪点268.1±30.1 °C
• 密度1.2±0.1 g/cm3
• PH:D -4° (10% alc)
• pKa:11.99±0.29(预测)
• PSA:105.53
• LogP:2.85
• 折射率1.545
• 蒸汽压0.0±3.1 mmHg at 25°C
• 溶解性6.754g/L(temperature not stated)
• 敏感性LASIOCARPINE is readily hydrolyzed by alkali. Reacts readily with oxidizing agents. Reacts slowly with atmospheric oxygen (NTP, 1992).
• 外观形态无色至米色结晶固体
• 储存条件Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• 产品应用LASIOCARPINE, 一种丙烯二氮碱藻类,对人类和肝细胞线有急性细胞毒性.

MSDS等安全信息

• GHS象形图
• GHS符号GHS06;
  注释: Skull and crossbones
• 危险类别急性毒性 类别3(经口)
  致癌性 类别2
  致突变性 类别2
  生殖毒性 类别2
  特定目标器官毒性-重复接触 类别1
• 警示词Danger(危险)
• 危险描述H301 |吞咽会中毒.
  H351 |怀疑致癌.
  H341 |怀疑导致遗传缺陷.
  H361d |怀疑对胎儿造成损害.
  H372 |长期或反复接触损害器官.
• 防范说明P264-P270-P301+P310-P321-P330-P405-P501
• 危险等级6.1(b)
• UN编号1544.0
• 包装等级III
• 安全声明H303+H313+H333
• 危险类别码Emergency treatment: Plants- pyrrolizidine alkaloids; Pyrrolizidine alkaloids (PAs) cause veno-occlusive liver disease. Diagnosis is difficult because symptoms may be delayed for days or weeks. After drinking herbal tea or eating plants contaminated with seeds of PA plants, symptoms may include vomiting, abdominal pain, hepatomegaly, and later cirrhosis and ascites. Jaundice may be present. Children may appear to have Reye's syndrome. [HSDB] Teas containing PAs include coltsfoot, comfrey, gordolobo, groundsel, mate, tansy ragwort, and T'u-san-chi. The teas may be prescribed as herbal remedies for anxiety or amenorrhea. The alkaloid is concentrated in the root of the plants. As little as 85 mg may be toxic. [Haddad, p. 1082]

欧盟法规

合成工艺路线路线简述

海关参考信息

• 2901210000-乙烯
  2901220000-丙烯
  2905122000-异丙醇
  2905143000-叔丁醇
• 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
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其他信息查阅

• ➥ 象形图和危险代码
• ➥ 防范代码详解
• ➥ 危险代码说明
• ➥ Globally Harmonized System
• ➥ REACH监管