CAS: 3025-95-4; N-Acetyl-B-Alanine

相似化合物

50632-82-1 1181590-67-9 31295-20-2

上下游产品

CAS号108-24-7 乙酸酐 | CAS号107-95-9 β-丙氨酸 | CAS号31295-20-2 N-乙酰基-β-丙氨酸甲酯 | CAS号154194-69-1 N-乙酰基-β-丙氨酸N-羟基琥珀酰亚胺

β-丙氨酸置于乙酸酐体系中,用 碳酸氢钠,乙腈 作为反应溶剂,以1.96 G (60%)的收率获得产物n-乙酰-β-丙氨酸
参考文献:Nucleoside Derivatives For Library Preparation
标题:Nucleoside Derivatives For Library Preparation
摘要:核苷衍生物作为模板库的构建模块被描述.

专利信息

专利号:US-10017481-B2
优先权日:2012-03-17
标 题 :Conformationally constrained, fully synthetic macrocyclic compounds
发明人：OBRECHT DANIEL; ERMERT PHILIPP; OUMOUCH SAID; PIETTRE ARNAUD; GOSALBES JEAN-FRANÇOIS; THOMMEN MARC
权利人:POLYPHOR AG
摘要:The conformationally restricted, spatially defined macrocyclic ring system of formula (I) is constituted by three distinct molecular parts: Template A, conformation Modulator B and Bridge C. Macrocycles described by this ring system I are readily manufactured by parallel synthesis or combinatorial chemistry in solution or on solid phase. They are designed to interact with a variety of specific biological target classes, examples being agonistic or antagonistic activity on G-protein coupled receptors (GPCRs), inhibitory activity on enzymes or antimicrobial activity. In particular, these macrocycles show inhibitory activity on endothelin converting enzyme of subtype 1 (ECE-1) and/or the cysteine protease cathepsin S (CatS), and/or act as antagonists of the oxytocin (OT) receptor, thyrotropin-releasing hormone (TRH) receptor and/or leukotriene B4 (LTB4) receptor, and/or as agonists of the bombesin 3 (BB3) receptor, and/or show antimicrobial activity against at least one bacterial strain. Thus they are showing great potential as medicaments for a variety of diseases.

专利号:US-2024209353-A1
优先权日:2021-04-08
标 题 :Nadk2 inhibition in cancer and fibrotic disorders
发明人：THOMPSON CRAIG B; SCHWOERER SIMON; ZHU JIAJUN
权利人:MEMORIAL SLOAN KETTERING CANCER CENTER; MEMORIAL HOSPITAL FOR CANCER AND ALLIED DISEASES; SLOAN KETTERING INST CANCER RES
摘要:Aspects of the disclosure provide methods for inhibiting cell proliferation and protein synthesis utilizing an antagonist of nicotinamide adenine dinucleotide kinase 2 (NADK2). In some aspects, these methods are used to treat a disease such as cancer or a disorder such as a fibrotic disorder. Further provided herein are compositions comprising a nutrient-deficient cell culture medium and an antagonist of NADK2.

专利号:RU-2166510-C2
优先权日:1993-02-22
标题 :Pseudodipeptides, methods of their synthesis, pharmaceutical compositions, methods of treatment

专利号:EP-2305808-B1
优先权日:2001-06-20
标 题:Templated molecules and methods for using such molecules
发明人：PEDERSEN HENRIK; GOULIAEV ALEX HAAHR; SAMS CHRISTIAN KLARNER; SLØK FRANK ABILGAARD; FRESKGÃ…RD PER-OLA; HOLTMANN ANETTE; OLSEN EVA KAMPMANN; HUSEMOEN GITTE NYSTRUP; FELDING JAKOB; FRANCH THOMAS; THISTED THOMAS; HYLDTOFT LENE; NØRREGAARD-MADSEN MADS; GODSKESEN MICHAEL ANDERS; GLAD SANNE SCHRØDER
权利人:NUEVOLUTION AS
摘要:The present invention relates to a method for synthesising templated molecules. In one aspect of the invention, the templated molecules are linked to the template which templated the synthesis thereof. The intion allows the generation of libraries which can be screened for e.g . therapeutic activity.

专利号:US-9688980-B2
优先权日:2001-06-20
标 题 :Templated molecules and methods for using such molecules
发明人：PEDERSEN HENRIK; GOULIAEV ALEX HAAHR; FRANCH THOMAS; SAMS CHRISTIAN KLARNER; OLSEN EVA KAMPMANN; SLOK FRANK ABILGAARD; HUSEMOEN GITTE NYSTRUP; FELDING JAKOB; HYLDTOFT LENE; NORREGAARD-MADSEN MADS; GODSKESEN MICHAEL ANDERS; GLAD SANNE SCHRODER; THISTED THOMAS; FRESKGARD PER-OLA; HOLTMANN ANETTE
权利人:NUEVOLUTION AS; NUEVOLUTION
摘要:The present invention relates to a method for synthesising templated molecules. In one aspect of the invention, the templated molecules are linked to the template which templated the synthesis thereof. The intion allows the generation of libraries which can be screened for e.g. therapeutic activity.