CAS: 23778-52-1; Pentaethylene Glycol Monomethyl Ether

该化合物是聚醚酒精,其特点是长碳链和多醚联系;该化合物具有一种具有水益性的头部,因为存在氢氧基(OH),碳氢化合物链的疏水尾巴,有助于其表面活性特性;通常用于各种应用,包括表面活性剂,乳化剂或制剂中的稳定剂;五醚联系在其结构中增加了水和有机溶剂中的溶性,使其在不同化学环境中具有可操作性;此外,其分子结构允许药物,化妆品和工业工艺中的潜在应用;该化合物一般认为毒性较低,但在具体的处理和使用准则中应始终参考安全数据;

结构式图片

相似化合物

4792-15-8 57671-28-0 141282-24-8

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CAS号6048-68-6 九甘醇单甲醚 | CAS号5498-83-9 氨基五甘醇单甲醚 | CAS号16024-66-1 m-PEG4-CH2COOH | CAS号4437-01-8 七甘醇单甲醚 | CAS号16142-03-3 m-PEG5-CH2COOH | CAS号25990-96-9 八聚乙二醇一甲醚 | CAS号1191-87-3 2,5,8,11,14,17-... | CAS号80755-67-5 m-PEG5-Tos

合成工艺路线路线简述

  • 合成目标产物 Pentaethylene Glycol Monomethyl Ether 主要起始原料 Bis[2-(2-Hydroxyethoxy)Ethyl] Ether And 1-Bromo-2-Methoxyethane
  • (文献来源)合成步骤主要原料 Bis[2-(2-Hydroxyethoxy)Ethyl] Ether 和 1-Bromo-2-Methoxyethane
三甘醇单甲醚置于吡啶,Sodium Hydride体系中,用 四氢呋喃,二氯甲烷 用作溶剂,化学反应 32.0H,反应生成2,5,8,11,14-五氧杂-16-十六烷醇
参考文献:设计具有低聚(乙二醇)侧链的非富勒烯受体:揭示增加的开路电压和平衡电荷载体迁移率的起源
标题:设计具有低聚(乙二醇)侧链的非富勒烯受体:揭示增加的开路电压和平衡电荷载体迁移率的起源
摘要:引入低聚(乙二醇)(oeg)链到基于dicyanodistyrylbenzene-Nonfullerene受体(nidcs)增加了其介电常数(ε-[r从3.3)至5.4.新nidcs受体(nidcs-Eo3)带有两个三乙二醇链显示出改善的开路电压(v oc),并用在本体异质结有机太阳能电池的各种供体的功率转换效率(pce中).
Doi:10.1002/asia.202100660

海关参考信息

专利信息


专利号:US-4340672-A
优先权日:1979-09-19
标 题:Enzymatic synthesis of β-lactam antibacterials
发明人:KONDO EIJI; MITSUGI TAKASHI; FUJIWARA TAMIO; MUNEYUKI RYONOSUKE
权利人:SHIONOGI & CO
摘要:Penicillins and cephalosporins can be synthesized by the action of an acylase on a penicillin or cephalosporin nucleus amine as substrate and an ester (I) of the following formula as the acyl source: (I) (wherein RCO is an acyl group in penicillin or cephalosporin side chains; X is a hydrogen atom, lower alkyl group or hydroxy-lower alkyl group; Y is a hydrogen atom or a lower alkyl group; and n is a positive integer). The novel acyl source (I) is also disclosed.

专利号:US-2010184989-A1
优先权日:2007-03-12
标 题 :De Novo Synthesis of Conjugates
发明人:RIGGS-SAUTHIER JENNIFER; DENG BO-LIANG; REN ZHONGXU; ZHANG WEN; GU XUYUAN; DUARTE FRANCO J
权利人:NEKTAR THERAPEUTICS
摘要:The invention provides methods for the preparation of small molecule drugs that are chemically modified by covalent attachment of a water-soluble oligomer obtained from a water-soluble oligomer composition. Such drugs are produced through modification of a synthetic pathway to attach the oligomer to an intermediate compound followed by completion of the synthetic path.

专利号:US-10787576-B2
优先权日:2015-04-30
标 题 :Method for the preparation of a coating comprising oligomeric alkynes
发明人:FRAUENRATH HOLGER; SCHRETTL STEPHEN; SCHULTE BJOERN; LETERRIER YVES
权利人:ECOLE POLYTECHNIQUE FED DE LAUSANNE EPFL EPFL TTO
摘要:The invention relates to a method for the preparation of a coating comprising at least one coating layer on a substrate, the method comprising the steps of a. providing monomers of the type R—(N) x -(L) m -(Câ•?C) n -(L′) o -(N′) y —R′, wherein R is a head moiety, R′ is a tail moiety, (C≡C) n is an oligoyne moiety, L and L′ are linker moieties, N and N′ independently are branched or unbranched optionally substituted C 1 -C 25 alkyl moieties optionally containing 1 to 5 heteroatoms, x, m, o, and y are independently 0 or 1, n is 4 to 12, and wherein the head moiety allows for an interaction with the surface of the substrate; b. bringing the monomers into contact with the substrate wherein the interaction of the head moieties of the monomers with the surface of the substrate induces at least a part of the monomers to align in a defined manner thereby forming a film on the surface and bringing the oligoyne moieties of the monomers into close contact with each other; c. inducing a reaction between oligoyne moieties by providing an external stimulus so as to at least partially cross-link the aligned monomers, thereby forming a coating layer on the substrate. The invention further relates to a coating obtainable according to the method of the invention, the use of a coating obtainable according to the method of the invention, a substrate comprising a coating obtainable according to the invention and the use of solid substrate. The invention further relates to a method for the synthesis ofthe monomers according to the invention.

专利号:CA-2679473-A1
优先权日:2007-03-12
标题:De novo synthesis of conjugates

专利号:EP-2125027-A2
优先权日:2007-03-12
标题:De novo synthesis of conjugates

专利号:WO-2008112286-A2
优先权日:2007-03-12
标题:De novo synthesis of conjugates
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主要参考文献


1: Brown A, Patel S, Ward C, Lorenz A, Ortiz M, DuRoss A, Wieghardt F, Esch A, Otten EG, Heiser LM, Korolchuk VI, Sun C, Sarkar S, Sahay G. PEG-lipid micelles enable cholesterol efflux in Niemann-Pick Type C1 disease-based lysosomal storage disorder. Sci Rep. 2016 Aug 30;6:31750. doi: 10.1038/srep31750.
2: Saifer MG, Williams LD, Sobczyk MA, Michaels SJ, Sherman MR. Selectivity of binding of PEGs and PEG-like oligomers to anti-PEG antibodies induced by methoxyPEG-proteins. Mol Immunol. 2014 Feb;57(2):236-46. doi: 10.1016/j.molimm.2013.07.014. Epub 2013 Nov 5. doi: 10.1517/17425247.2012.720969. Epub 2012 Aug 30.

合成参考文献


参考文献:10.1002/prot.22038
摘要:Aragão KS, Satre M, Imberty A, Varrot A. Structure determination of Discoidin II from Dictyostelium discoideum and carbohydrate binding properties of the lectin domain. Proteins. 2008 Oct;73(1):43–52. doi: 10.1002/prot.22038.
参考文献:10.1021/acsmedchemlett.0c00247
摘要:Preston A, Atkinson SJ, Bamborough P, Chung C, Gordon LJ, Grandi P, Gray JRJ, Harrison LA, Lewis AJ, Lugo D, Messenger C, Michon A, Mitchell DJ, Prinjha RK, Rioja I, Seal J, Taylor S, Thesmar P, Wall ID, Watson RJ, Woolven JM, Demont EH. GSK973 Is an Inhibitor of the Second Bromodomains (BD2s) of the Bromodomain and Extra-Terminal (BET) Family. ACS Med. Chem. Lett. 2020 Jul 06;11(8):1581–7. doi: 10.1021/acsmedchemlett.0c00247.
摘要:S55 | ZINC15PHARMA | Pharmaceuticals from ZINC15 | DOI:10.5281/zenodo.3247749
摘要:S120 | DUSTCT2024 | Substances from Second NORMAN Collaborative Dust Trial | DOI:10.5281/zenodo.13835254
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