CAS: 219967-74-5; (S)-3-((((9H-Fluoren-9-yl)Methoxy)Carbonyl)Amino)-5-Phenylpentanoic Acid

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CAS号82732-07-8 B°C-D-高苯丙氨酸 | CAS号218608-84-5 (S)-N-叔丁氧羰基-3-氨...

Boc-L-高苯丙氨酸置于n-甲基吗啉,水,Silver Trifluoroacetate,Sodium Carbonate,氯甲酸异丁酯体系中,用 四氢呋喃,三乙胺,丙酮 用作溶剂,化学反应 11.33H,反应生成(S)-N-芴甲氧羰基-3-氨基-5-苯基戊酸
参考文献:(S)-β3-Homolysine-And (S)-β3-Homoserine-Containingβ-Peptides: Cd Spectra In Aqueous Solution
标题:(S)-β3-Homolysine-And (S)-β3-Homoserine-Containingβ-Peptides: Cd Spectra In Aqueous Solution
摘要:For Further Structural Studies And For Physiological Investigations Of Beta-Peptides,It Is Necessary To Have H2O-Soluble Derivatives. Thus,We Have Prepared Beta-Hexa-,Beta-Hepta-,And Beta-Nonapeptides (1-6) With Two,Three,And Seven Side Chains Of Lysine And Serine. To Detect Possible Pi-Pi Interactions,We Also Included The Beta-Amino Acid Beta(2)-Hhop,Resulting From Homologation Of So-Called Homophenylalanine (Hop) (5 And 6). The Fmoc-Beta(2)-And Beta(3)-Amino-Acid Derivatives (11-14 And 19),And The Corresponding Beta-Peptides Were Prepared By Methods Previously Described (Solid-Phase Peptide Coupling; HPLC-Pure Samples,Fig. I). Circular-Dichroism Spectra (Fig.2) Indicate The Presence Of Less Pronounced Secondary Structures (Especially Of The Lysine Analogues With Multiple Positive Charge) In H2O As Compared To Meoh. The Beta(3)-Heptapeptide (3) With Two Serine Side Chains Is Well Soluble In H2O And Exhibits The Cd Pattern Typical Of The 3(1)-Helical Structure.
Doi:10.1002/(Sici)1522-2675(19981216)81:12<2141::Aid-Hlca2141>3.0.Co;2-5