CAS: 16727-43-8; 2,6-Dimethoxynicotinic Acid

相似化合物

65515-26-6 58819-72-0 1227594-72-0

上下游产品

methanol 2,6-dichloropyridine-3-carboxylic acid 2,6-dimethoxynicotinoyl chloride 2,6-dimethoxynicotinic acid ethyl ester N-benzyl-2-cyclohexyl-2-[2-(2,6-dimethoxy-pyridin-3-yl)-5,6-difluoro-benzoimidazol-1-yl]-acetamide 1-(benzyloxy)-4-bromo-3,3,4,4-tetrafluorobutan-2-yl 2,6-dimethoxynicotinate

甲醇,2,6-二氯烟酸置于potassium Tert-Butylate体系中,化学反应 1.0H,反应生成6-氯-2-甲氧基 烟酸,2,6-二甲氧基吡啶-3-羧酸,2-氯-6-甲氧基烟酸
参考文献:使用微波和流动反应技术的组合首次合成 2-氨基-6-甲氧基烟酸甲酯
标题:使用微波和流动反应技术的组合首次合成 2-氨基-6-甲氧基烟酸甲酯
摘要:报道了 2-氨基-6-甲氧基烟酸甲酯的合成,这是制备稠合 2-吡啶酮的重要组成部分.优化的合成包括连续的微波诱导区域选择性 6-甲氧基化,酯化,然后微波诱导与对甲氧基苄胺反应,最后在流动反应氢化条件下脱保护.报道的合成中的两个关键步骤是微波诱导的甲氧基化和微流体氢化,它们提供了改进的反应产物的区域选择性和纯度分布.
Doi:10.1055/s-0030-1259283

专利信息

专利号:WO-0053579-A2
优先权日:1999-03-10
标 题:Solid phase synthesis of 4-aminoproline derivatives and/or combinatorial libraries thereof

专利号:US-9217012-B2
优先权日:2009-04-08
标题 :Inhibitors of protein tyrosine phosphatases
发明人：ZHANG ZHONG-YIN; ZHANG SHENG
权利人:ZHANG ZHONG-YIN; ZHANG SHENG; UNIV INDIANA RES & TECH CORP
摘要:Disclosed herein are compounds that selectively inhibit members of the PTP family of enzymes. Synthesized compounds demonstrated selective inhibition of TC-PTP. Also provided are methods of using the compounds and formulations containing the compounds. Also described is a fluorescence-tagged combinatorial library synthesis and screening method. And methods of using these compounds to effect enzyme activity both in cells and in vitro as well as method of using these compounds to treat diseases in human and animals.