CAS: 16088-07-6; 2-Amino-3-Phenylpropan-1-Ol

该化合物是源自苯丙烯的手性氨基酒精,通常用作有机合成和制药应用的多用途中间体,其种族形式包括D-和L-enantiomers,在立体化学研究和不对称合成方面具有灵活性,该化合物因其在生产手性辅助剂,皮甘地和活性药物成分(APIs)方面的作用而受到重视.其氢氧基和氨基功能组可以进行多种衍生,有利于发展消化和精美化学品.DL-Phenylalalanol还因其稳定的结构和再活动而被用于催化和解析过程.高纯度等级确保研究和工业环境的一贯性能.

结构式图片

相似化合物

106454-69-7 129397-83-7 3182-95-4

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ECHA物质C&L通报REACH预注册

上下游产品

ethyl N-acetyl-DL-phenylalaninate Z-β-ethoxycarbonyl-β-nitrostyrene phenylalanine ethyl ester acetic acid-(β-nitro-cinnamyl ester)1-bromomethyl-2-phenyl-ethylamine 2-acetamido-3-phenylpropanol acetate 2-(2,4-dinitro-anilino)-3-phenyl-propan-1-ol 2-benzoylamino-1-benzoyloxy-3-phenyl-propane

合成工艺路线路线简述

    📜L-苯丙氨酸乙酯盐酸盐置于lithium Aluminium Tetrahydride体系中,用 乙醚 用作溶剂,化学反应 2.0H,以0.8 G的收率获得dl-2-氨基-3-苯基-1-丙醇
    参考文献:Us2014/275273
    标题:Us2014/275273

    海关参考信息

    专利信息


    专利号:US-7323575-B2
    优先权日:2003-04-09
    标题:Process for the synthesis of (2S)-indoline-2-carboxylic acid
    发明人:SOUVIE JEAN-CLAUDE; LECOUVE JEAN-PIERRE
    权利人:SERVIER LAB
    摘要:Process for the synthesis of (2S)-indoline-2-carboxylic acid of formula (I): n nApplication in the synthesis of perindopril and its pharmaceutically acceptable salts.

    专利号:WO-0140193-A1
    优先权日:1999-12-03
    标题:Method for the synthesis of pyrazolines
    发明人:BOLDI ARMEN M
    权利人:CHEMRX ADVANCED TECHNOLOGIES I; BOLDI ARMEN M
    摘要:The present invention provides a method for the synthesis of compounds of Formula (I). Also claimed are novel intermediates and their methods of synthesis.

    专利号:US-2002103381-A1
    优先权日:2000-11-30
    标 题 :Method for the synthesis of pyrazolines
    发明人:BOLDI ARMEN M
    摘要:The present invention provides a method for the synthesis of compounds of Formula I: n n n Also claimed are novel intermediates and their methods of synthesis.

    专利号:US-9950988-B2
    优先权日:2012-12-26
    标题:Method for the synthesis of alpha/alpha-prime-alcoxylated glycerol linear carbonic esters
    发明人:LEISING FRéDéRIC; MOULOUNGUI ZéPHIRIN
    权利人:CHRYSO; INST NAT POLYTECHNIQUE TOULOUSE; INST NAT DE LA RECH AGRONOMIQUE INRA
    摘要:A method for the synthesis of α/α′-alcoxylated glycerol linear carbonic esters, wherein the following are brought into contact at a reaction temperature lower than 220° C.: a quantity of at least one precursor selected from the group consisting of α/α′-alcoxylated glycerol cyclo-carbonates; a quantity of at least one catalyst selected from the group consisting of metal oxides, Lewis acids, organometallic catalysts and mineral bases; and a quantity of at least one organic primer. A composition containing at least one novel α/α′-alkoxylated glycerol linear carbonic ester.

    专利号:US-10040752-B2
    优先权日:2015-08-24
    标 题 :Synthesis of levomethadone hydrochloride or dextromethadone hydrochloride and methods for use thereof
    发明人:MKRTCHYAN GNEL; YAO QINGWEI
    权利人:CODY LABORATORIES INC
    摘要:Highly efficient methods for synthesis of levomethadone hydrochloride or dextromethadone hydrochloride are provided starting from D-alanine, or L-alanine, respectively, with retention of configuration. Methods for treating a subject are provided comprising administering a composition comprising an effective amount of levomethadone hydrochloride having not more than 10 ppm dextromethadone.

    专利号:US-7189864-B2
    优先权日:1990-11-19
    标 题:Method of preparing intermediates useful in synthesis of retroviral protease inhibitors
    发明人:NG JOHN S; PRZYBYLA CLAIRE A; MUELLER RICHARD A; VAZQUEZ MICHAEL L; GETMAN DANIEL P
    权利人:SEARLE & CO
    摘要:A synthesis is described for intermediates which are readily amenable to the large scale preparation of hydroxyethylurea-based chiral HIV protease inhibitors. The method includes forming a diastereoselective epoxide from a chiral alpha amino aldehyde.

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    ✅ COA系统入驻 | 共享模式

    合成参考文献


    摘要:Harris, P. A., Science of Synthesis Knowledge Updates, (2021) 3, 172.
    摘要:Fleischer, I.; Mejía, E., Science of Synthesis: C-1 Building Blocks in Organic Synthesis, (2013) 1, 125.
    参考文献:10.1021/jo010479t
    摘要:Pugh VJ, Hu QS, Zuo X, Lewis FD, Pu L. Optically active BINOL core-based phenyleneethynylene dendrimers for the enantioselective fluorescent recognition of amino alcohols. J Org Chem. 2001 Sep 07;66(18):6136–40. doi: 10.1021/jo010479t.
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