CAS: 150828-96-9; Boc-Orn(Fmoc)-Oh

上下游产品

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide (R)-5-amino-2-((tert-butoxycarbonyl)amino)pentanoic acid 2-(tert-butoxycarbonyl)-L-ornithineN2-(tert-butoxycarbonyl)-L-ornithineH-Tyr-D-Orn[*]-Phe-Asp[*]-NH2 glycyl-L-arginyl-glycyl-L-aspartyl-L-seryl-L-proline

,Boc-L-鸟氨酸置于碳酸氢钠体系中,用 四氢呋喃,水 用作溶剂,化学反应 2.0H,以81%的收率获得n-叔丁氧羰基-N'-芴甲氧羰基-L-鸟氨酸
参考文献:肽-腺嘌呤结合物的合成作为监测蛋白酶活性的新工具
标题:肽-腺嘌呤结合物的合成作为监测蛋白酶活性的新工具
摘要:我们报道了一种有效的方法来合成具有挑战性的肽-腺嘌呤结合物,以替代氨甲基香豆素(amc)-丝氨酸蛋白酶底物.
Doi:10.1002/ejoc.201801490

专利信息

专利号:US-2021130409-A1
优先权日:2017-09-01
标 题 :Method for the Solid-Phase Synthesis of Cyclic Pentapeptides
发明人：ZHENGGUO JIANG; LUCIANO FORNI; ROBERTSON ALAN
权利人:Alsonex Pty Ltd
摘要:A method for the synthesis of a cyclic ornithine-proline-D-cyclohexylalanine-tryptophan-arginine pentapeptide of Formula A; n n n n n n n n n n n n wherein R 1 and R 2 are, independently, —H, or —C(O)R 3 where R 3 is —CH 2 Ph, —CH 2 CH 2 Ph, —CHâ•?CHPh, —C(NHAC)CH 2 Ph;n nthe method comprising the steps of;n nforming a linear proline-D-cyclohexylalanine-tryptophan-arginine-ornithine pentapeptide of Formula B, attached to a polymeric resin;n n n n n n n n n n n n n n n n n wherein R 1 is as for Formula A, RES indicates the polymeric resin, and P 1 and P 2 are protecting groups;n ncyclising the linear pentapeptide of Formula B to form a cyclic pentapeptide of Formula C, attached to the polymeric resin;n n n n n n n n n n n n n n n cleaving the cyclic peptide of Formula C from the resin providing a cleaved cyclic pentapeptide having a free amine group of an ornithine residue;n noptionally substituting the free amine group of the ornithine residue of the cleaved cyclic peptide;n nremoving the protecting groups P 1 and P 2 , to providethe cyclic peptide of Formula A.

专利号:US-7038037-B2
优先权日:2002-06-20
标题 :Method for sequential support-bound synthesis of conjugated oligomeric compounds
发明人：MAIER MARTIN A; GUZAEV ANDREI P; MANOHARAN MUTHIAH
权利人:ISIS PHARMACEUTICALS INC
摘要:A sequential support-bound synthesis method is disclosed for preparing a conjugated oligomeric compound, preferably a PNA-peptide conjugate or an oligonucleotide-peptide conjugate, using a bridging molecule having at least two N-protecting amino groups. A conjugated oligomeric compound for therapeutic or prophylactic delivery is also disclosed.

专利号:US-11319348-B2
优先权日:2016-10-28
标题:Synthetic beta-amyloid peptides capable of forming stable antigenic oligomers
发明人：NOWICK JAMES S; KREUTZER ADAM G; SPENCER RYAN K; SALVESON PATRICK J
权利人:UNIV CALIFORNIA
摘要:Synthetic Aβ peptides, oligomers, their methods of synthesis, and their applications are provided. The Aβ peptides can form stable, soluble oligomers important for the advancement of knowledge, detection, and treatment of Alzheimer's disease. Antibodies specific to oligomeric Aβ and their methods of synthesis are also described.

专利号:US-2004006203-A1
优先权日:2002-06-20
标题 :Method for sequential support-bound synthesis of conjugated oligomeric compounds