专利号:US-9370515-B2 优先权日:2013-03-07 标题 :Mixed lineage kinase inhibitors and method of treatments 发明人:GOODFELLOW VAL S; NGUYEN THONG X; RAVULA SATHEESH B; GELBARD HARRIS A 权利人:CALIFIA BIO INC; UNIV ROCHESTER 摘要:Provided herein are imidazopyridine compounds having an inhibitory effect on mixed lineage kinases (MLKs), methods of their synthesis, and methods of their therapeutic. Also provided are pharmaceutical compositions comprising the compounds and methods of using the compounds and pharmaceutical compositions.
专利号:WO-9845272-A1 优先权日:1997-04-07 标题:Topoisomerase inhibitors 发明人:DEADY LESLIE WILLIAM; DENNY WILLIAM ALEXANDER; KAYE ANTHONY JAMES 权利人:UNIV LATROBE; DEADY LESLIE WILLIAM; DENNY WILLIAM ALEXANDER; KAYE ANTHONY JAMES 摘要:The invention provides a novel series of tetracyclic quinoline and quinoxaline carboxamides, bis compounds in which two of the tetracyclic compounds are joined by a linker, and pharmaceutically-acceptable salts and N-oxides thereof, which have the ability to inhibit topoisomerase activity. The compounds are active in vitro and in vivo against tumour cells. Methods of synthesis and pharmaceutical compositions are also claimed.
参考文献:10.2991/978-94-6463-829-5_34 摘要:Yu L, Liu S, Meng Q, Wang B. Investigation into the Distinction in Identification of Engine Oil and Gasoline Residues at a Fire Scene. 2025. In: Advances in Engineering Research.