CAS: 14049-03-7; (2S,3S,4R,5R)-3-Fluoro-2,4,5,6-Tetrahydroxyhexanal

相似化合物

29702-43-0 99605-33-1 52904-86-6

上下游产品

Diacetone D-glucose 3-deoxy-1,2;5,6-di-O-isopropylidene-3-fluoro-α-D-glucofuranose 1,2:5,6-di-O-isopropylidene-3-O-trifluoromethanesulfonyl-α-D-allofuranose 1,2,4,6-tetra-O-acetyl-3-deoxy-3-fluoro-β-D-glucopyranose 1,2,4,6-tetra-O-acetyl-3-deoxy-3-fluoro-α-D-glucopyranose

📜1,2:5,6-Di-O-Isopropylidene-3-O-Trifluoromethanesulfonyl-α-D-Allofuranose置于cesium Fluoride体系中,用 1,4-二氧六环,水,叔丁醇 用作溶剂,化学反应 44.0H,反应生成3-氟-3-脱氧-D-吡喃糖
参考文献:3-Fluoroazetidinecarboxylic Acids And Trans,Trans-3,4-Difluoroproline As Peptide Scaffolds: Inhibition Of Pancreatic Cancer Cell Growth By A Fluoroazetidine Iminosugar
标题:3-Fluoroazetidinecarboxylic Acids And Trans,Trans-3,4-Difluoroproline As Peptide Scaffolds: Inhibition Of Pancreatic Cancer Cell Growth By A Fluoroazetidine Iminosugar
摘要:Reverse Aldol Opening Tenders Amides Of 3-Hydroxyazetidinecarboxylic Acids (3-Oh-Aze) Unstable Above Ph 8. Axe,Found In Sugar Beet,Is Mis-Incorporated For Proline In Peptides In Humans And Is Associated With Multiple Sclerosis And Teratogenesis. Axe-Containing Peptides May Be Oxygenated By Prolyl Hydroxylases Resulting In Potential Damage Of The Protein By A Reverse Aldol Of The Hydroxyazetidine; This,Rather Than Changes In Conformation; May Account For The Deleterious Effects Of Axe. This Paper Describes The Synthesis Of 3-Fluoro-Aze Amino Acids As Hydroxy-Aze Analogues Which Are Not Susceptible To Aldol Cleavage. 4-(Azidomethyl)-3-Fluoro-Aze And 3,4-Difluoroproline Are New Peptide Building Blocks. Trans,Trans-2,4-Dihydroxy-3-Fluoroazetidine,An Iminosugar,Inhibits The Growth Of Pancreatic Cancer Cells To A Similar Degree As Gemcitabine.
Doi:10.1021/acs.Joc.5B00463

专利信息

专利号:US-8845999-B2
优先权日:2005-05-23
标 题 :Tracers for monitoring the activity of sodium/glucose cotransporters in health and disease
发明人：WRIGHT ERNEST M; BARRIO JORGE R; HIRAYAMA BRUCE A; KEPE VLADIMIR
权利人:WRIGHT ERNEST M; BARRIO JORGE R; HIRAYAMA BRUCE A; KEPE VLADIMIR; UNIV CALIFORNIA
摘要:Radiolabeled tracers for sodium/glucose cotransporters (SGLTs), their synthesis, and their use are provided. The tracers are methyl or ethyl pyranosides having an equatorial hydroxyl group at carbon-2 and a C 1 preferred conformation, radiolabeled with 18 F, 123 I, or 124 I, or free hexoses radiolabeled with 18 F, 123 I, or 124 . Also provided are in vivo and in vitro techniques for using these and other tracers as analytical and diagnostic tools to study glucose transport, in health and disease, and to evaluate therapeutic interventions.

专利号:RU-2193032-C2
优先权日:1997-07-17
标 题 :Derivatives of polyhydroxyalkylpyrazines, their synthesis and medicinal agents comprising thereof