CAS: 136572-09-3; (S)-4,11-Diethyl-4-Hydroxy-3,14-Dioxo-3,4,12,14-Tetrahydro-1H-Pyrano[3',4':6,7]Indolizino[1,2-B]Quinolin-9-Yl [1,4'-Bipiperidine]-1'-Carboxylate Hydrochloride Trihydrate

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CAS号100286-90-6 盐酸依立替康

专利信息

专利号:US-12383499-B2
优先权日:2018-01-01
标题:Scale up synthesis of silicasome nanocarriers
发明人：NEL ANDRE E; MENG HUAN; LIU XIANGSHENG
权利人:UNIV CALIFORNIA
摘要:In order to facilitate the approval and commercialization of silicasome drug delivery systems (e.g. irinotecan silicasomes) it is necessary to scale up synthesis of the drug-loaded silicasomes. In this regard, it was discovered that the synthesis protocols used for laboratory synthesis of drug-loaded silicasomes (e.g., 500 mg/batch) do not scale to large scale silicasome production, because the resulting products were too heterogeneous for use as pharmaceuticals. Accordingly, new methods are provided herein that effectively afford the large-scale production of mesoporous silica nanoparticles (MSNPs) and lipid bilayer coated MSNPs (silicasomes).

专利号:US-2022118094-A1
优先权日:2019-02-21
标题:Synthesis of biomimetic cell wall structure
发明人：WANG YONG; SHI PENG
权利人:PENN STATE RES FOUND
摘要:The present invention relates generally to methods of generating a biomimetic cell wall (BCW) on a target surface, compositions comprising the BCW, and methods of use of the compositions, including biomedical applications of the BCW coated compositions.

专利号:WO-2012032531-A1
优先权日:2010-09-06
标 题:Process for the manufacture of irinotecan hydrochloride by total synthesis
发明人：ALLA VENKATA RAMA RAO; RAO RAMAKRISHNA; RAMARAO CHANDRASHEKAR; NANDIPATI RAMADEVI; CHAMLE VINAY AVINASH
权利人:AVRA LAB PVT LTD; ALLA VENKATA RAMA RAO; RAO RAMAKRISHNA; RAMARAO CHANDRASHEKAR; NANDIPATI RAMADEVI; CHAMLE VINAY AVINASH
摘要:Disclosed herein is a highly safe and easily scalable process for the production of 7-Ethyl- 10-hydroxycamptothecin and its conversion to Irinotecan hydrochloride by total synthesis.

专利号:EP-3735250-A1
优先权日:2018-01-01
标题:Scale up synthesis of silicasome nanocarriers

专利号:US-2019216736-A1
优先权日:2018-01-01
标题:Scale up synthesis of silicasome nanocarriers

专利号:JP-2008505893-A
优先权日:2004-07-07
标题:Synthesis of Minus Beta Element, Minus Beta Elemental, Minus Beta Elementenol, Minus Beta Fluorinated Elementene and Their Analogues, Intermediates and Drugs