CAS: 13534-98-0; 4-Amino-3-Bromopyridine

相似化合物

257937-08-9 89364-04-5 84539-34-4

上下游产品

CAS号1678-49-5 3-溴-4-硝基吡啶 N-氧化物 | CAS号504-24-5 4-氨基吡啶 | CAS号13534-90-2 3,4-二溴吡啶 | CAS号114080-98-7 3-bromo-N-hydro... | CAS号70298-89-4 4-(2,2,2-三甲基乙酰胺)吡啶 | CAS号135041-83-7 4-amino-3-bromo... | CAS号141375-60-2 4-amino-3-bromo... | CAS号902837-39-2 4-氨基-5-碘-3-溴吡啶 | CAS号88511-27-7 4-氨基-3-碘吡啶 | CAS号84539-34-4 4-氨基-3,5-二溴吡啶 | CAS号70298-89-4 4-(2,2,2-三甲基乙酰胺)吡啶 | CAS号104830-01-5 3-(2-氨基-3-吡啶基)丙烯酸乙酯 | CAS号13535-03-0 4-(Acetylamino)... | CAS号271-34-1 1H-吡咯并[3,2-c]吡啶 | CAS号23616-29-7 1,6-萘二酮 | CAS号257937-08-9 (3-溴吡啶-4-基)氨基甲酸叔丁酯 | CAS号37388-07-1 2-苯基-1H-吡咯并[3,2-c]吡啶

4-氨基吡啶置于n-溴代丁二酰亚胺(Nbs)体系中,用 乙腈 用作溶剂,化学反应 48.0H,以86%的收率获得4-氨基-3-溴吡啶
参考文献:路易斯酸介导的环异构化 合成吡咯并[1,2-A ]萘啶†
标题:路易斯酸介导的环异构化 合成吡咯并[1,2-A ]萘啶†
摘要:由3-炔基-2-([[1 H ]-吡咯-1-基)吡啶和3-炔基-4-([1 H ]-吡咯-1-基)合成吡咯并[1,2-A ]萘啶吡啶经环异构化.通过施加路易斯酸ptcl 2或bi(otf)3进行反应,而无需其他添加剂.利用所描述的方法,已经以高达78%的收率合成了许多包含各种官能团的衍生物.
Doi:10.1039/c7Ob00343A

专利信息

专利号:US-3901899-A
优先权日:1973-04-27
标题 :Synthesis of indoles from anilines and intermediates therein
发明人：GASSMAN PAUL G
权利人:UNIV OHIO STATE RES FOUND
摘要:Preparing indoles and intermediates therefor by reacting an Nhaloaniline with a Beta -carbonylic hydrocarbon sulfide to form an azasulfonium halide, reacting the azasulfonium halide with a strong base to form a thio-ether indole derivative, and then reducing the thio-ether indole, e.g. with Raney nickel, to form the indole compound. When an acetal or ketal of the Beta carbonyl hydrocarbon sulfide is used, the azasulfonium salt is treated with a base, and then with an acid to form the thio-ether indole derivative. When an Alpha -ethyl- Beta -carbonylic hydrocarbon sulfide is used, the resulting azosulfonium salt reacts with strong base to form a thio-ether indolenine derivative, which on reduction with Raney nickel or complex metal hydrides yields 3-substituted indoles. The aniline may be an aminopyridine to form an aza-indole compound in the process. The azasulfonium salts and thio-ether indole or thio-ether indolenine derivatives can be isolated and recovered from their respective reaction mixtures. The thio-ether-indole and thio-ether indolenine derivatives are useful as intermediates to make the indoles without the thio-ether group. The indoles are known compounds having a wide variety of uses, e.g., in making perfumes, dyes, amino acids, pharmaceuticals, agricultural chemicals and the like.

专利号:US-3992392-A
优先权日:1973-04-27
标题:Synthesis of indoles from anilines and intermediates therein
发明人：GASSMAN PAUL G
权利人:UNIV OHIO STATE RES FOUND
摘要:Preparing indoles and intermediates therefor by reacting an N-haloaniline with a β-carbonylic hydrocarbon sulfide to form an azasulfonium halide, reacting the azasulfonium halide with a strong base to form a thio-ether indole derivative, and then reducing the thio-ether indole, e.g. with Raney nickel, to form the indole compound. When an acetal or ketal of the β-carbonyl hydrocarbon sulfide is used, the azasulfonium salt is treated with a base, and then with an acid to form the thio-ether indole derivative. When an α-ethyl-β -carbonylic hydrocarbon sulfide is used, the resulting azosulfonium salt reacts with strong base to form a thio-ether indolenine derivative, which on reduction with Raney nickel or complex metal hydrides yields 3-substituted indoles. The aniline may be an aminopyridine to form an aza-indole compound in the process. The azasulfonium salts and thio-ether indole or thio-ether indolenine derivatives can be isolated and recovered from their respective reaction mixtures. The thio-ether-indole and thio-ether indolenine derivatives are useful as intermediates to make the indoles without the thio-ether group. The indoles are known compounds having a wide variety of uses, e.g., in making perfumes, dyes, amino acids, pharmaceuticals, agricultural chemicals and the like.

专利号:US-2017355648-A1
优先权日:2016-04-26
标题 :Synthesis of meta-substituted [18f]-3-fluoro-4-aminopyridines by direct radiofluorination of pyridine n-oxides

专利号:US-10160695-B2
优先权日:2016-04-26
标 题 :Synthesis of meta-substituted [18F]-3-fluoro-4-aminopyridines by direct radiofluorination of pyridine N-oxides
发明人：BRUGAROLAS PEDRO
权利人:UNIV CHICAGO
摘要:Disclosed herein are methods for the fluorination aromatic N-heterocyclic N-oxides that comprise at least one leaving group. The N-oxides may be reduced to the fluorinated aromatic N-heterocyclic amine analogs. This novel fluorination approach may be successfully applied for synthesizing aromatic N-heterocyclic compounds labeled with 18 F.

专利号:CN-102898360-A
优先权日:2012-11-12
标题 :Synthesis of 3,5-Dibromo-4-fluoropyridine

专利号:CN-102898359-A
优先权日:2012-11-12
标题:Synthesis of 3,5-dibromo-4-iodopyridine