CAS: 130-49-4; Adenosine-2'-Monophosphate

相似化合物

84-21-9 61-19-8 18422-05-4

上下游产品

5'-O-(triphenylmethyl)adenosine pyridine dibenzyl phosph°Chloridate acetic acid [3']adenylic acid monobenzyl ester adenosine monophosphate adenosine 2',3'-cyclic monophosphate β-D-ribofuranose

📜5'-Phosphoryladenylyl-(2'-5')-Adenylyl-(2'-5')-2',3'-O-(1-Methoxyhexadecylidene)Adenosine置于sodium Hydroxide,Alkaline Phosphatase体系中,用 水 用作溶剂,化学反应 18.0H,反应生成腺苷酸2(3)-磷酸
参考文献:Pressova,Martina; Smrt,Jiri,Collection Of Czechoslovak Chemical Communications,1989,Vol. 54,# 2,P. 487-497
标题:Pressova,Martina; Smrt,Jiri,Collection Of Czechoslovak Chemical Communications,1989,Vol. 54,# 2,P. 487-497

专利信息

专利号:US-4266048-A
优先权日:1977-10-11
标题:Synthesis of analogs of 3'-phosphoadenosine 5'-phosphosulfate (PAPS)
发明人：HORWITZ JEROME P; NEENAN JOHN P; MISRA RADHEY S; ROZHIN JURIJ; HUO ANNE; PHILIPS KERSTIN D
权利人:US HEALTH EDUCATION & WELFARE
摘要:Analogs of 3'-phosphoadenosine 5'-phosphosulfate, also known as PAPS, are useful in establishing sulfate transfer mechanisms in animals and may be produced by a chemical process yielding an analog B of a pure adenosine 2',3'-cyclic phosphate 5'-phosphate, which compound is initially prepared from the reaction of adenosine and pyrophosphoryl chloride. In the present process an analog B is selected from 8-bromoadenine, purine, hypoxanthine, 4-aminopyrrolo[2,3-d]pyrimidine (tubercidin), and 7-amino-pyrazolopyrimidine (formycin). In the pilot procedure the pure cyclic phosphate is reacted with triethylamine-N-sulfonic acid to produce 2',3'-cyclic phosphate 5'-phosphosulfate. Subsequently, by hydrolysis with the enzyme ribonuclease-T 2 , the desired compound, an analog of PAPS, is produced. Alternatively, the 2'-phosphoadenosine 5'-phosphosulfate, known as iso-PAPS, may be produced from 2',3'-cyclic phosphate 5'-phosphosulfate by treatment with a different enzyme, PDase II or spleen phosphodiesterase.

专利号:US-7928207-B2
优先权日:2004-06-28
标 题:Synthesis and compositions of nucleic acids comprising 2′-terminator nucleotides
发明人：BODEPUDI VEERAIAH; GUPTA AMAR P; WILL STEPHEN G
权利人:ROCHE MOLECULAR SYSTEMS INC
摘要:The invention provides methods of producing blocked oligonucleotides that include 2′-terminator nucleotides. These blocked oligonucleotides are used primers and probes in a variety of nucleic acid technologies. Related kits are also provided.

专利号:US-7947817-B2
优先权日:2003-06-30
标题 :Synthesis and compositions of 2'-terminator nucleotides
发明人：BODEPUDI VEERAIAH; WILL STEPHEN GORDON; GELFAND DAVID HARROW
权利人:ROCHE MOLECULAR SYSTEMS INC
摘要:The invention provides compositions that comprise nucleotides and/or nucleosides having blocking groups at 2′-positions of sugar moieties. Methods of synthesizing these nucleic acids are also provided.

专利号:US-10144928-B2
优先权日:2013-08-23
标 题:Double stranded oligonucleotide compounds comprising positional modifications
发明人：AVKIN-NACHUM SHARON; FEINSTEIN ELENA; BEIGELMAN LEONID
权利人:QUARK PHARMACEUTICALS INC
摘要:Disclosed herein are double stranded RNA molecules which have been modified to exhibit one of the following, increased activity, enhanced nuclease stability, reduced off target activity and or reduced immunogenicity, to pharmaceutical compositions comprising such compounds and to methods of use. Further disclosed is a method for the synthesis of threose nucleic acid phosphoramidites and methods of use thereof.

专利号:EP-1957644-A2
优先权日:2005-12-01
标题 :Enzymatic encoding methods for efficient synthesis of large libraries

专利号:US-5739013-A
优先权日:1993-09-24
标 题 :Enzymatic synthesis of 2',5'-oligoadenylate-2',3'-cyclophosphates and treatment of papillomaviruses